固体脂质纳米粒的制备及在化妆品领域的应用
Preparation of Solid Lipid Nanoparticles and Its Applications in Cosmetics
摘要: 固体脂质纳米粒(SLNs)是由表面活性剂所稳定的以固态的形式存在的胶体系统,具有缓释、靶向性、低毒性、良好的生物相容性、生物可降解性以及可以提高药物生物利用度和稳定性等特点。SLNs作为一种递送载体,目前已开始被用于化妆品的制造。本文总结了SLNs常用的制备方法,介绍了SLNs在化妆品领域的应用,并对其应用前景进行了展望。
Abstract: Solid lipid nanoparticles (SLNs) are particulate colloidal systems comprised of solid core lipids, which are stabilized by surfactants. SLNs show various distinctive features such as prolonged drug release, drug targeting, low toxicity, excellent biocompatibility, biodegradability and enhancing bioavailability and stability of drugs. Some of the delivery systems based on SLNs have been used in the development of cosmetics. This literature review describes the preparation techniques of SLNs, the applications and prospects of SLNs in cosmetics.
文章引用:程明娇, 刘晨光. 固体脂质纳米粒的制备及在化妆品领域的应用[J]. 材料科学, 2020, 10(4): 192-200. https://doi.org/10.12677/MS.2020.104025

参考文献

[1] Geszke-Moritz, M. and Moritz, M. (2016) Solid Lipid Nanoparticles as Attractive Drug Vehicles: Composition, Prop-erties and Therapeutic Strategies. Materials Science & Engineering. C, Materials for Biological Applications, 68, 982-994. [Google Scholar] [CrossRef] [PubMed]
[2] Battaglia, L. and Gallarate, M. (2012) Lipid Nanoparti-cles: State of the Art, New Preparation Methods and Challenges in Drug Delivery. Expert Opinion on Drug Delivery, 9, 497-508. [Google Scholar] [CrossRef] [PubMed]
[3] Müller, R.H., Maèder, K. and Gohla, S. (2000) Solid Lipid Nanoparticles (SLN) for Controlled Drug Delivery: A Review of the State of the Art. European Journal of Pharmaceutics and Biopharmaceutics, 50, 161-177. [Google Scholar] [CrossRef
[4] Mehnert, W. and Karsten, M. (2012) Solid Lipid Nanoparticles: Production, Characterization and Applications. Advanced Drug Delivery Reviews, 47, 165-196. [Google Scholar] [CrossRef
[5] Mühlen, A.Z., Schwarz, C. and Mehnert, W. (1998) Solid Lipid Nanoparticles (SLN) for Controlled Drug Delivery-Drug Release and Release Mechanism. European Journal of Pharmaceutics and Biopharmaceutics, 45, 149-155. [Google Scholar] [CrossRef
[6] Ganesan, P. and Narayanasamy, D. (2017) Lipid Nanoparticles: Different Preparation Techniques, Characterization, Hurdles, and Strategies for the Production of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Oral Drug Delivery. Sustainable Chemistry and Pharmacy, 6, 37-56. [Google Scholar] [CrossRef
[7] Kadian, R. (2018) Nanoparticles: A Promising Drug Delivery Approach. Asian Journal of Pharmaceutical & Clinical Research, 11, 30. [Google Scholar] [CrossRef
[8] Jaiswal P., Gidwani, B. and Vyas, A. (2016) Nanostructured Lipid Carriers and Their Current Application in Targeted Drug Delivery. Artificial Cells, Nanomedicine, and Biotechnology, 44, 27-40. [Google Scholar] [CrossRef] [PubMed]
[9] Chattopadhyay, P., Huff, R. and Shekunov, B.Y. (2006) Drug Encapsulation Using Supercritical Fluid Extraction of Emulsions. Journal of Pharmaceutical Sciences, 95, 667-679. [Google Scholar] [CrossRef] [PubMed]
[10] Saraf, S., Kaur, C.D., Gupta, A. and Verma, N. (2019) Skin Targeting Approaches in Cosmetics. Indian Journal of Pharmaceutical Education and Research, 53, 577-594. [Google Scholar] [CrossRef
[11] Sala, M., Diab, R., Elaissari, A. and Fessi, H. (2018) Lipid Nanocarriers as Skin Drug Delivery Systems: Properties, Mechanisms of Skin Interactions and Medical Applications. International Journal of Pharmaceutics, 535, 1-17. [Google Scholar] [CrossRef] [PubMed]
[12] Puglia, C., Bonina, F., Rizza, L., Blasi, P., Schoubben, A., Perrotta, R., Tarico, M.S. and Damiani, E. (2012) Lipid Nanoparticles as Carrier for Octyl-Methoxycinnamate: In Vitro Percutaneous Absorption and Photostability Studies. Journal of Pharmaceutical Sciences, 101, 301-311. [Google Scholar] [CrossRef] [PubMed]
[13] Wissing, S.A. and Müller, R.H. (2003) Cosmetic Applications for Solid Lipid Nanoparticles (SLN). International Journal of Pharmaceutics, 254, 65-68. [Google Scholar] [CrossRef
[14] Jose, J. and Netto, G. (2018) Role of Solid Lipid Nanopar-ticles as Photoprotective Agents in Cosmetics. Journal of Cosmetic Dermatology, 18, 315-321. [Google Scholar] [CrossRef] [PubMed]
[15] Song, C. and Liu, S. (2005) A New Healthy Sunscreen System for Human: Solid Lipid Nanoparticles as Carrier for 3,4,5-Trimethoxybenzoylchitin and the Improvement by Adding Vitamin E. International Journal of Biological Macromolecules, 36, 116-119. [Google Scholar] [CrossRef] [PubMed]
[16] Vinh, V.T., Ju-Young, M. and Young-Chul, L. (2019) Lipo-somes for Delivery of Antioxidants in Cosmeceuticals: Challenges and Development Strategies. Journal of Controlled Release, 300, 114-140. [Google Scholar] [CrossRef] [PubMed]
[17] Suter, F., Schmid, D., Wandrey, F., et al. (2016) Heptapeptide-Loaded Solid Lipid Nanoparticles for Cosmetic Anti-Aging Applications. European Journal of Pharmaceutics and Biopharmaceutics, 108, 304-309. [Google Scholar] [CrossRef] [PubMed]
[18] Mitri, K., Shegokar, R., Gohla, S., Anselmi, C. and Rainer, H.M. (2011) Lipid Nanocarriers for Dermal Delivery of Lutein: Prep-aration, Characterization, Stability and Performance. International Journal of Pharmaceutics, 414, 267-275. [Google Scholar] [CrossRef] [PubMed]
[19] Yuan, C., Du, L., Jin, Z. and Xu, X. (2013) Storage Stability and Antioxidant Activity of Complex of Astaxanthin with Hydroxypropyl-β-Cyclodextrin. Carbohydrate Polymers, 91, 385-389. [Google Scholar] [CrossRef] [PubMed]
[20] Li, M., Zahi, M.R., Yuan, Q., Tian, F. and Liang, H. (2016) Preparation and Stability of Astaxanthin Solid Lipid Nanoparticles Based on Stearic Acid. European Journal of Lipid Science and Technology, 118, 592-602. [Google Scholar] [CrossRef
[21] Shiva, G., Mohsen, M. and Reza, J.M. (2012) Preparation, Characterization and Evaluation of Moisturizing and UV Protecting Effects of Topical Solid Lipid Nanoparticles. Brazilian Journal of Pharmaceutical Sciences, 48, 683-690. [Google Scholar] [CrossRef
[22] Katsambas, A.A.D. and Katoulis, A.C. (1999) Topical Retinoids in the Treatment of Aging of the Skin. Advances in Experimental Medicine and Biology, 455, 477-482. [Google Scholar] [CrossRef] [PubMed]
[23] Jeon, H.S., Seo, J.E., Kim, M.S., et al. (2013) A Retinyl Palmitate-Loaded Solid Lipid Nanoparticle System: Effect of Surface Modification with Dicetyl Phosphate on Skin Permeation in Vitro and Anti-Wrinkle Effect in Vivo. International Journal of Pharmaceutics, 452, 311-320. [Google Scholar] [CrossRef] [PubMed]
[24] Kim, H., Kim, J.T., Barua, S., et al. (2017) Seeking Better Topical Delivery Technologies of Moisturizing Agents for Enhanced Skin Moisturization. Expert Opinion on Drug Delivery, 15, 17-31. [Google Scholar] [CrossRef] [PubMed]
[25] Barua, S., Lee, D.I., Kim, H., et al. (2018) Solid Lipid Nanoparticles of Serine Designed by Evaluating Affinity of Solid Lipids to Stratum Corneum for Enhanced Skin Hydration in Combination with Reed Root Extract. Bulletin of the Korean Chemical Society, 39, 220-226. [Google Scholar] [CrossRef
[26] Wissing, S.A. and Müller, R.H. (2002) The Influence of the Crystallinity of Lipid Nanoparticles on Their Occlusive Properties. International Journal of Pharmaceutics, 242, 377-379. [Google Scholar] [CrossRef
[27] Montenegro, L., Parenti, C., Turnaturi, R. and Pasquinucci, L. (2017) Resveratrol-Loaded Lipid Nanocarriers: Correlation between in Vitro Occlusion Factor and in Vivo Skin Hydrating Effect. Pharmaceutics, 9, 58. [Google Scholar] [CrossRef] [PubMed]
[28] Puglia, C., Bonina, F., Castelli, F., Micieli, D. and Sarpietro, M.G. (2009) Evaluation of Percutaneous Absorption of the Repellent Diethyltoluamide and the Sunscreen Ethylhexylp-Methoxycinnamate-Loaded Solid Lipid Nanoparticles: An in-Vitro Study. Pharmacy and Pharmacology, 61, 1013-1019. [Google Scholar] [CrossRef] [PubMed]
[29] Pardeike, J., Hommoss, A. and Müller, R.H. (2009) Lipid Nanoparticles (SLN, NLC) in Cosmetic and Pharmaceutical Dermal Products. International Journal of Pharmaceutics, 366, 170-184. [Google Scholar] [CrossRef] [PubMed]
[30] Hsieh, P.W., Aljuffali, I.A., Fang, C.L., Chang, S.H. and Fang, J.Y. (2014) Hydroquinone-Salicylic Acid Conjugates as Novel Anti-Melasma Actives Show Superior Skin Targeting Compared to the Parent Drugs. Journal of Dermatological Science, 76, 120-131. [Google Scholar] [CrossRef] [PubMed]
[31] Ghanbarzadeh, S., Hariri, R., Kouhsoltani, M., Shokri, J. and Hamishehkar, H. (2015) Enhanced Stability and Dermal Delivery of Hydroquinone Using Solid Lipid Nanoparticles. Colloids & Surfaces B Biointerfaces, 136, 1004-1010. [Google Scholar] [CrossRef] [PubMed]