芬太尼类化合物的临床应用及研究进展
Clinical Application and Research Progress of Fentanyl Compounds
DOI: 10.12677/CC.2019.34005, PDF,   
作者: 张军军, 白育庭, 胡文祥：湖北科技学院药学院，湖北 咸宁；邵开元：北京神剑天军医学科学院京东祥鹄微波化学联合实验室，北京
关键词: 芬太尼；临床应用；麻醉镇痛；Fentanyl； Clinical Application； Anesthesia and Analgesia
摘要: 芬太尼类化合物作为μ型阿片受体激动剂，具有高效的镇痛麻醉作用，在临床上得到了广泛应用，研究者对其结构进行了改造和修饰，芬太尼类似物快速发展，已有部分应用于临床，如舒芬太尼、阿芬太尼等，本文对芬太尼类化合物的临床研究进展作如下综述。
Abstract: Fentanyl compounds, as μ opioid receptor agonists, have highly effective analgesic and anesthetic effects, and have been widely used in clinical practice. Researchers have transformed and modified their structures, and Fentanyl analogues have developed rapidly. Some of them have been used in clinical practice, such as sufentanil and alfentanil. In this paper, the clinical research progress of Fentanyl compounds is summarized as follows.
文章引用：张军军, 白育庭, 邵开元, 胡文祥. 芬太尼类化合物的临床应用及研究进展[J]. 比较化学, 2019, 3(4): 27-33. https://doi.org/10.12677/CC.2019.34005

参考文献

[1] Yaksh, T.L. (1984) Multiple Opioid Receptor Systems in Brain and Spinal Cord: Part I. European Journal of Anaes-thesiology, 1, 201-243.
[2] Stein, C. and Lang, L.J. (2009) Peripheral Mechanisms of Opioid Analgesia. Current Opinion in Pharmacology, 9, 3-8. [Google Scholar] [CrossRef] [PubMed]
[3] Sibinga, N.E.S. and Goldstein, A. (1988) Opioid Peptides and Opioid Receptors in Cells of the Immune System. Annual Review of Immunology, 6, 219-249. [Google Scholar] [CrossRef] [PubMed]
[4] Fields, H.L., Emson, P.C., Leigh, B.K., et al. (1980) Multiple Opiate Receptor Sites on Primary Afferent Fibres. Nature, 284, 351-353. [Google Scholar] [CrossRef] [PubMed]
[5] Gormley, W.P., Murray, J.M., Fee, J.P., et al. (1996) Effect of the Addition of Alfentanil to Lignocaine during Axillary Brachial Plexus Anaesthesia. British Journal of Anaesthesia, 76, 802-805. [Google Scholar] [CrossRef] [PubMed]
[6] Sanchez, R., Nielsen, H., Heslet, L., et al. (1984) Neuronal Blockade with Morphine: A Hypothesis. Anaesthesia, 39, 788-789. [Google Scholar] [CrossRef] [PubMed]
[7] Viel, E.J., Eledjam, J.J., Coussaye, J.E.D.L., et al. (1989) Brachial Plexus Block with Opiods for Postoperative Pain Relief. Comparison between Buprenorphine and Morphine. Regional Anesthesia, 14, 274-278.
[8] Fletcher, D., Kuhlman, G. and Samii, K. (1994) Addition of Fentanyl to 1.5% Lidocaine Does Not Increase the Success of Axillary Plexus Block. Regional Anesthesia & Pain Medicine, 19, 183-188.
[9] Racz, H., Gunning, K., Santa, D.D., et al. (1991) Evaluation of the Effect of Perineuronal Morphine on the Quality of Postoperative Analgesia after Axillary Plexus Block. Anesthesia & Analgesia, 72, 769-772. [Google Scholar] [CrossRef] [PubMed]
[10] Nishikawa, K., Kanaya, N., Nakayama, M., et al. (2000) Fentanyl Improves Analgesia But Prolongs the Onset of Axillary Brachial Plexus Block by Peripheral Mechanism. Anesthesia & Analgesia, 91, 384-387. [Google Scholar] [CrossRef] 
[11] Rivat, C., Laulin, J.P., Corcuff, J.B., et al. (2002) Fen-tanyl Enhancement of Carrageenan-Induced Long-Lasting Hyperalgesia in Rats. Anesthesiology, 96, 381-391. [Google Scholar] [CrossRef] [PubMed]
[12] Maynard, R.L. (1997) The Pharmacological Basis of Therapeutics. Occupational & Environmental Medicine, 54, 69. [Google Scholar] [CrossRef] 
[13] Rayburn, W., Rathke, A., Leuschen, M.P., et al. (1989) Fentanyl Citrate Analgesia during Labor. American Journal of Obstetrics and Gynecology, 161, 202-206. [Google Scholar] [CrossRef] [PubMed]
[14] Michiels, M., Hendriks, R. and Heykants, J. (1977) A Sensi-tive Radioimmunoassay for Fentanyl. European Journal of Clinical Pharmacology, 12, 153-158. [Google Scholar] [CrossRef] 
[15] Striebel, H.W., Pommerening, J. and Rieger, A. (1993) Intranasal Fen-tanyl Titration for Postoperative Pain Management in an Unselected Population. Anaesthesia, 48, 753-757. [Google Scholar] [CrossRef] [PubMed]
[16] Striebel, H.W., Koenigs, D. and Kramer, J. (1992) Postoperative Pain Management by Intranasal Demand-Adapted Fentanyl Titration. Anesthesiology, 77, 281-285. [Google Scholar] [CrossRef] [PubMed]
[17] Wong, P., Chadwick, F.D. and Karovits, J. (2003) In-tranasal Fentanyl for Postoperative Analgesia after Elective Caesarean Section. Anaesthesia, 58, 818-819. [Google Scholar] [CrossRef] [PubMed]
[18] Fischer, R.L., Lubenow, T.R., Liceaga, A., et al. (1988) Comparison of Continuous Epidural Infusion of Fentanyl-Bupivacaine and Morphine-Bupivacaine in Management of Postoperative Pain. Anesthesia & Analgesia, 67, 559-563. [Google Scholar] [CrossRef] 
[19] Loper, K.A., Ready, L.B., Downey, M., et al. (1990) Epidural and Intravenous Fentanyl Infusions Are Clinically Equivalent after Knee Surgery. Anesthesia & Analgesia, 70, 72-75. [Google Scholar] [CrossRef] [PubMed]
[20] Cooper, D.W., Ryall, D.M. and Desira, W.R. (1995) Extradural Fentanyl for Postoperative Analgesia: Predominant Spinal or Systemic Action? British Journal of Anaesthesia, 74, 184-187. [Google Scholar] [CrossRef] [PubMed]
[21] Grant, R.P., Dolman, J.F. and Harper, J.A. (1992) Patient-Controlled Lumbar Epidural Fentanyl Compared with Patient-Controlled Intravenous Fentanyl for Post-Thoracotomy Pain. Canadian Journal of Anesthesia, 39, 214-219. [Google Scholar] [CrossRef] 
[22] Ellis, D.J., Millar, W.L. and Reisner, L.S. (1990) A Randomized Dou-ble-Blind Comparison of Epidural versus Intravenous Fentanyl Infusion for Analgesia after Cesarean Section. Anesthe-siology, 72, 981-986. [Google Scholar] [CrossRef] [PubMed]
[23] Carrie, L.E.S., O’Sullivan, G.M. and Seegobin, R. (1981) Epidural Fentanyl in Labour. Anaesthesia, 36, 965-969. [Google Scholar] [CrossRef] [PubMed]
[24] Behar, M. (1979) Epidural Morphine in Treatment of Pain. The Lancet, 313, 527-529. [Google Scholar] [CrossRef] 
[25] Stanley, T.H. and Webster, L.R. (1979) Anesthetic Re-quirements and Cardiovascular Effects of Fentanyl-Oxygen and Fentanyl-Diazepam-Oxygen Anesthesia in Man. An-esthesia & Analgesia, 57, 411-416. [Google Scholar] [CrossRef] [PubMed]
[26] Stanley, T.H., Philbin, D.M. and Coggins, C.H. (1979) Fentanyl-Oxygen Anaesthesia for Coronary Artery Surgery: Cardiovascular and Antidiuretic Hormone Responses. Canadian Anaesthetists Society Journal, 26, 168-172. [Google Scholar] [CrossRef] 
[27] Klausner, J.M., Caspi, J., Lelcuk, S., et al. (1988) Delayed Muscular Rigidity and Respiratory Depression Following Fentanyl Anesthesia. Archives of Surgery, 123, 66. [Google Scholar] [CrossRef] [PubMed]
[28] 农智艺. 舒芬太尼临床应用及研究进展综述[J]. 双足与保健, 2017, 26(22): 196-198.
[29] Flacke, J.W., Bloor, B.C., Kripke, B.J., et al. (1985) Comparison of Mor-phine, Meperidine, Fentanyl, and Sufentanil in Balanced Anesthesia. Anesthesia & Analgesia, 64, 897-910. [Google Scholar] [CrossRef] 
[30] Zuurmond, W.W.A. and Leeuwen, L.V. (1987) Recov-ery from Sufentanil Anaesthesia for Outpatient Arthroscopy: A Comparison with Isoflurane. Acta Anaesthesiologica Scandinavica, 31, 154-156. [Google Scholar] [CrossRef] [PubMed]
[31] 苗蕾. 罗哌卡因复合舒芬太尼用于剖宫产麻醉的临床效果[J]. 河南医学研究, 2020, 29(10): 1802-1803.
[32] 陈丽娟. 低浓度罗哌卡因复合舒芬太尼用于产妇自控硬膜外分娩镇痛的临床观察[J]. 心理月刊, 2020, 15(8): 170.
[33] Van den Hoogen, R.H.W.M., Bervoets, K.J.W., et al. (1988) Respiratory Effects of Epidural and Subcutaneous Morphine, Meperidine, Fentanyl and Sufentanil in the Rat. Anesthesia & Analgesia, 67, 1071-1078. [Google Scholar] [CrossRef] 
[34] 杨博文, 赵志刚, 邵开元, 胡文祥. 芬太尼类药物研究进展[J]. 药物化学, 2017, 5(3): 52-59.
[35] Murkin, J.M. (1987) Book Reviews. Canadian Journal of Anaesthesia, 34, 99-100. [Google Scholar] [CrossRef] 
[36] Chang, J. and Fish, K.J. (1985) Acute Respiratory Arrest and Rigidity after Anesthesia with Sufentanil. Anesthesiology, 63, 710-711. [Google Scholar] [CrossRef] [PubMed]
[37] Madej, T.H. and Strunin, L. (1987) Comparison of Epidural Fentanyl with Sufentanil Analgesia and Side Effects after a Single Bolus Dose during Elective Caesarean Section. Anaesthesia, 42, 1156-1161. [Google Scholar] [CrossRef] [PubMed]
[38] Wilhelm, W., Wrobel, M., Kreuer, S., et al. (2003) Remifentanil. Der Anaesthesist, 52, 473-494. [Google Scholar] [CrossRef] [PubMed]
[39] Jones, R.M. (1996) Remifentanil. Drugs, 52, 428. [Google Scholar] [CrossRef] [PubMed]
[40] 贾娟, 石翊飒. 瑞芬太尼诱发痛觉过敏相关受体机制的研究进展[J]. 中国疼痛医学杂志, 2016, 22(9): 696-699.
[41] 黎必万. 瑞芬太尼的研究进展及临床应用现状[J]. 临床合理用药杂志, 2009, 2(13): 127-128.
[42] 谢言虎, 方才. 瑞芬太尼的临床应用现状[J]. 国外医学(麻醉学与复苏分册), 2005(5): 298-300.
[43] 李力兵, 苏畅, 马兰, 等. 瑞芬太尼对心率影响的临床与实验研究[J]. 中国临床药理学与治疗学, 2009, 14(9): 1047-1051.
[44] 冯琳, 胡文祥. 4-甲氧羰基芬太尼1位磷酰化的合成研究[C]//中国化学会公共安全中的化学问题研究进展(第二卷). 北京: 中国化学会, 2011: 804-805.
[45] 杨玉龙, 卢志英. 4-甲氧甲基芬太尼类似物的合成及其镇痛作用[J]. 药学学报, 1991, 26(7): 493-498.