钠通道阻滞剂对局灶性癫痫患者皮层兴奋性的影响

Effect of Sodium Channel Blocker on Cortical Excitability in Patients with Focal Epilepsy

摘要: 目的：探讨局灶性癫痫患者及钠通道阻滞剂类抗癫痫药物(Anti-epileptic drugs，AEDs)对受试者大脑皮层兴奋性影响的差异。方法：受试者分为局灶未服药组(n = 14)、局灶服药组(n = 17)及正常对照组(n = 15)共3组。利用经颅磁刺激技术测量受试者静息运动阈值、运动诱发电位波幅及潜伏期并对测量值进行统计比较。结果：局灶未服药组与局灶服药组间静息运动阈值的差异具有统计学意义(P = 0.017)；运动诱发电位波幅的明显差异出现在局灶未服药组(P₁ = 0.033)以及局灶服药组(P₂ = 0.038)分别与正常对照组的比较中。结论：局灶性癫痫患者较正常人群皮层兴奋性水平明显升高；钠通道阻滞剂能够明显抑制局灶性癫痫患者皮层兴奋性水平。

Abstract: Objective: To investigate the difference of excitability of cerebral cortex between patients with focal epilepsy and those with antiepileptic drugs (AEDs). Methods: The subjects were divided into five groups: focal epilepsy without medication (n = 14), focal epilepsy with medication (n = 17) and normal group (n = 15). The subjects who met the standard were selected to measure the resting motor threshold, the amplitude and latency of motor evoked potential by transcranial magnetic stimulation, and the measured values were compared statistically. Results: In the comparison of resting motor thresholds among groups, there were statistically significant differences between the focal epilepsy without medication and the group of focal epilepsy with medication (P = 0.017). The significant differences in the amplitude of motor evoked potential among groups were found in the comparison of the focal epilepsy without medication and the normal control group respectively (P₁ = 0.033). The same difference lies in the group of focal epilepsy with medication and the normal control group respectively (P₂ = 0.038). Conclusion: The cortical excitability of patients with focal epilepsy is significantly higher than that of normal people, and sodium channel blocker can significantly inhibit the cortical excitability level of patients with focal epilepsy.