长链非编码RNA RMRP RNA功能的多样性

Multifunction of LncRNA RMRP RNA

摘要:

RMRP RNA是一个长链非编码RNA，它具有多种功能，包括和其它蛋白形成核酸内切酶RNase MRP，产生2种miRNA，作为miRNA海绵，和转录因子结合调控基因表达以及产生1种siRNA，从不同层面调控基因表达。RMRP RNA广泛参与不同的生命过程，异常表达的RMRP RNA也参与癌症和各种疾病的发生。

Abstract: RMRP RNA is an LncRNA which is multifunctional. It forms nucleic acid endonuclease RNase MRP with other proteins and produces 2 miRNAs and a siRNA. What’s more, RMRP RNA combines with transcription factor to regulate gene expression and acts as a miRNA sponge. This is how RMRP RNA regulates gene expression in different ways. RMRP RNA is widely involved in different life processes, and abnormally expressed RMRP RNA is also involved in the development of cancer and various diseases. Some mutations of RMRP RNA can cause dwarfism. Starting from the different functions of RMRP RNA, this review expounds the relationship between RMRP RNA and life process and various diseases, and also explores the molecular mechanism of RMRP RNA in it, so as to provide a refer-ence for the follow-up research of RMRP RNA.

文章引用：付洪, 赵浩宇, 郭泰林. 长链非编码RNA RMRP RNA功能的多样性[J]. 生物物理学, 2020, 8(2): 19-27. https://doi.org/10.12677/BIPHY.2020.82002

参考文献

[1]	[1] Quinn, J.J. and Chang, H.Y. (2016) Unique Features of Long Non-Coding RNA Biogenesis and Function. Nature Re-views Genetics, 17, 47-62. [Google Scholar] [CrossRef] [PubMed]
[2]	Wang, K.C. and Chang, H.Y. (2011) Molecu-lar Mechanisms of Long Noncoding RNAs. Molecular Cell, 43, 904-914. [Google Scholar] [CrossRef] [PubMed]
[3]	Gill, T., et al. (2004) RNase MRP Cleaves the CLB2 mRNA to Promote Cell Cycle Progression: Novel Method of mRNA Degradation. Molecular and Cellular Biology, 24, 945-953. [Google Scholar] [CrossRef]
[4]	Mattijssen, S., et al. (2011) Viperin mRNA Is a Novel Tar-get for the Human RNase MRP/RNase P Endoribonuclease. Cellular and Molecular Life Sciences, 68, 2469-2480. [Google Scholar] [CrossRef] [PubMed]
[5]	Goldfarb, K.C. and Cech, T.R. (2017) Targeted CRISPR Disrup-tion Reveals a Role for RNase MRP RNA in Human Preribosomal RNA Processing. Genes & Development, 31, 59-71. [Google Scholar] [CrossRef] [PubMed]
[6]	Rogler, L.E., et al. (2014) Small RNAs Derived from lncRNA RNase MRP Have Gene-Silencing Activity Relevant to Human Cartilage-Hair Hypoplasia. Human Molecular Genetics, 23, 368-382. [Google Scholar] [CrossRef] [PubMed]
[7]	Shao, Y.F., Li, Q.E., Sun, W.L., Ye, G.L., Zhang, X.J., Yang, Y.B., et al. (2016) LncRNA-RMRP Promotes Carcinogenesis by Acting as a miR-206 Sponge and Is Used as a Novel Biomarker for Gastric Cancer. Oncotarget, 7, 37812-37824. [Google Scholar] [CrossRef] [PubMed]
[8]	Wang, J., Xiao, T. and Zhao, M. (2019) MicroRNA-675 Directly Targets MAPK1 to Suppress the Oncogenicity of Papillary Thyroid Cancer and Is Sponged by Long Non-Coding RNA RMRP. OncoTargets and Therapy, 12, 7307-7321. [Google Scholar] [CrossRef]
[9]	Huang, W., et al. (2015) DDX5 and Its Associated lncRNA Rmrp Modulate TH17 Cell Effector Functions. Nature, 528, 517-522. [Google Scholar] [CrossRef] [PubMed]
[10]	Maida, Y., et al. (2009) An RNA-Dependent RNA Polymerase Formed by TERT and the RMRP RNA. Nature, 461, 230-235. [Google Scholar] [CrossRef] [PubMed]
[11]	Hermanns, P., et al. (2005) Consequences of Mutations in the Non-Coding RMRP RNA in Cartilage-Hair Hypoplasia. Human Molecular Genetics, 14, 3723-3740. [Google Scholar] [CrossRef] [PubMed]
[12]	Hermanns, P., et al. (2006) RMRP Mutations in Cartilage-Hair Hypo-plasia. American Journal of Medical Genetics Part A, 140, 2121-2130. [Google Scholar] [CrossRef] [PubMed]
[13]	Feng, W., et al. (2017) Up-Regulation of the Long Non-Coding RNA RMRP Contributes to Glioma Progression and Promotes Glioma Cell Proliferation and Invasion. Archives of Medical Science, 13, 1315-1321. [Google Scholar] [CrossRef] [PubMed]
[14]	Viji Mythily Draviam, S.O., Lowe, M., Pardi, R. and Pines, J. (2001) The Localization of Human Cyclins B1 and B2 Determines CDK1 Substrate Specificity and Neither Enzyme Re-quires MEK to Disassemble the Golgi Apparatus. The Journal of Cell Biology, 152, 945-958. [Google Scholar] [CrossRef] [PubMed]
[15]	Teng, T.S., et al. (2012) Viperin Restricts Chikungunya Virus Replica-tion and Pathology. Journal of Clinical Investigation, 122, 4447-4460. [Google Scholar] [CrossRef]
[16]	Karwan, R. (1993) RNase MRP/RNase P: A Structure-Function Relation Conserved in Evolution. FEBS Letters, 319, 1-4. [Google Scholar] [CrossRef]
[17]	Steinbusch, M.M.F., et al. (2017) Expression of RMRP RNA Is Regulated in Chondrocyte Hypertrophy and Determines Chondro-genic Differentiation. Scientific Reports, 7, Article No. 6440. [Google Scholar] [CrossRef] [PubMed]
[18]	Huang, Y., et al. (2015) Long Noncoding RNA H19 Promotes Osteoblast Differentiation via TGF-beta1/Smad3/HDAC Signaling Pathway by Deriving miR-675. Stem Cells, 33, 3481-3492. [Google Scholar] [CrossRef] [PubMed]
[19]	Inose, H., et al. (2009) A microRNA Regulatory Mechanism of Osteoblast Differentiation. Proceedings of the National Academy of Sciences of the United States of America, 106, 20794-20799. [Google Scholar] [CrossRef] [PubMed]
[20]	Zhang, S.Y., et al. (2019) Upregulation of lncRNA RMRP Promotes the Activation of Cardiac Fibroblasts by Regulating miR613. Molecular Medicine Reports, 20, 3849-3857. [Google Scholar] [CrossRef] [PubMed]
[21]	Han, Y., et al. (2020) lncRNA RMRP Prevents Mito-chondrial Dysfunction and Cardiomyocyte Apoptosis via the miR-1-5p/hsp70 Axis in LPS-Induced Sepsis Mice. In-flammation, 43, 605-618. [Google Scholar] [CrossRef] [PubMed]
[22]	Teng, Y., et al. (2020) LncRNA RMRP Accelerates Hypox-ia-Induced Injury by Targeting miR-214-5p in H9c2 Cells. Journal of Pharmacological Sciences, 142, 69-78. [Google Scholar] [CrossRef] [PubMed]
[23]	Maida, Y., et al. (2013) Off-Target Effect of Endogenous siRNA Derived from RMRP in Human Cells. International Journal of Molecular Sciences, 14, 9305-9318. [Google Scholar] [CrossRef] [PubMed]