APO B/APO A1比值、FIB水平与冠脉病变程度相关性

Correlation between APO B/APO A1, FIB Level and Coronary Lesions

摘要: 目的：探讨载脂蛋白B/载脂蛋白A1比值(APO B/APO A1)、血浆纤维蛋白原(FIB)水平与冠心病患者冠脉病变程度相关性。方法：选取冠心病患者152例，对照组69例，分别测定其APO B/APO A1比值、FIB水平，比较两组结果并分析其与冠状动脉病变程度的关系。结果：冠心病患者的APO B/APO A1比值、FIB水平均明显高于对照组(P < 0.05)。多支病变组APO B/APO A1比值、FIB水平明显高于单支病变组(P < 0.05)。Gensini评分重度组APO B/APO A1比值显著高于轻度组，差异具有统计学意义(P < 0.05)。FIB在Gensini评分重度组和轻度组中差异无统计学意义。在相关性分析中，冠心病患者中APO B/APO A1比值、FIB与Gensini评分均显著正相关(r = 0.266，0.372，P均<0.05)。结论：APO B/APO A1比值、FIB水平的升高与冠心病的发生及冠脉病变程度具有相关性。

Abstract: Objective: To explore the correlation between the levels of apolipoprotein B/apolipoprotein A1 (APO B/APO A1) and plasma fibrinogen (FIB) and the degree of coronary artery disease in patients with coronary heart disease. Methods: A total of 152 patients with coronary heart disease and 69 patients in the control group were selected. The levels of APO B/APO A1 and FIB were measured respectively. The results of the two groups were compared and their relationship with the degree of coronary artery disease was analyzed. Results: The levels of APO B/APO A1 and FIB in patients with coronary heart disease were significantly higher than those in the control group (P < 0.05). The APO B/APO A1 and FIB in the multi-vessel disease group were significantly higher than that in the single-vessel disease group (P < 0.05). Gensini score in severe group APO B/APO A1 was significantly higher than mild group, the difference was statistically significant (P < 0.05). FIB had no statistically significant difference between the severe and mild groups of Gensini score. In the correlation analysis, APO B/APO A1, FIB and Gensini scores in patients with coronary heart disease were significantly positively correlated (r = 0.266, 0.372, P < 0.05). Conclusion: The increase of APO B/APO A1 and FIB levels is related to the occurrence of coronary heart disease and the degree of coronary artery disease.