左旋肉碱补充剂对超重与肥胖人群血脂水平影响的Meta分析

The Effects of L-CarnitineSupplementation on the Lipid Profiles in Over-weight or Obesity Population: A Meta-Analysis

摘要: 目的：评价左旋肉碱补充剂对超重与肥胖人群血脂水平的作用。方法：通过系统检索中国知网(CNKI)、万方数据知识服务平台、维普网、PubMed、ScienceDirect等数据库，检索时间从建库至2020年6月。根据Cochrane系统评价方法，筛选采用左旋肉碱(试验组)对比安慰剂(对照组)治疗超重、肥胖患者的随机对照试验(RCT)，进行纳入文献的资料提取和质量评价，采用Rev Man 5.3软件进行Meta分析。比较试验组与对照组总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、体脂率(BF%)、体重、体质指数(BMI)、腰臀比(WHR)等指标。结果：共纳入8篇符合标准的随机对照试验。Meta分析结果显示，试验组TC水平(SMD = 0.23, 95%CI[0.03,0.43], P = 0.02)、TG水平(SMD = 0.21, 95%CI[0.01,0.41], P = 0.04)、LDL水平(SMD = 0.32,95%CI[0.08, 0.56], P = 0.008)、BMI水平(MD = 1.01, 95%CI[0.27,1.74], P = 0.007)、WHR水平(MD = 0.02,95%CI[0.00, 0.04], P = 0.02)降低程度大于对照组；两组在HDL水平升高程度(SMD = 0.20, 95%CI[−0.04, 0.43], P = 0.10)、体重和BF%降低程度(体重：MD = 1.26, 95%CI[−1.36, 3.87], P = 0.35；BF%: MD = 2.51, 95%CI[−0.16, 5.17], P = 0.07)的差异无统计学意义。结论：左旋肉碱补充剂显著改善超重、肥胖人群的TC、TG、LDL水平。

Abstract: Objective: To evaluate the effects of L-carnitine supplementation on lipid profile in overweight and obesity population. Methods: A comprehensive systematic literature search in the electronic databases, including CNKI, Wanfang, VIP, Pub Med, Science Direct, were carried out upto June, 2020. According to the standard procedures of The Cochrane Collaboration, randomized control trials that use L-carnitine supplementation (experiment group) and placebo in overweight and obesity population were selected. Data were extracted and quality was assessed, and the meta-analysis was conducted using Rev Man 5.3 software. The parameters, including total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), body fat rate (BF%), body weight, body mass index (BMI), and waist-hip ratio (WHR), were analyzed and compared between experiment and control group. Results: 8 RCTs of adequate methodological quality were included in the study. Results from meta-analysis of eligible trials revealed that subjects in experiment group had significant greater declines in TC (SMD = 0.23, 95%CI: 0.03, 0.43, P = 0.02), TG (SMD = 0.21, 95%CI: 0.01, 0.41, P = 0.04), LDL-C (SMD = 0.32, 95%CI: 0.08, 0.56, P = 0.008), BMI (MD = 1.01, 95%CI: 0.27, 1.74, P = 0.007) and WHR (MD = 0.02, 95%CI: 0.00, 0.04, P = 0.02) than those of the subjects in control group. There were no significant differences in the changes of HDL-C, body weight (MD = 1.26, 95%CI: −1.36, 3.87, P = 0.35) and BF% (MD = 2.51, 95%CI: −0.16, 5.17, P = 0.07) among the subjects in these two groups. Conclusion: L-carnitine supplement could result in significant improvement inTC, TG and LDL-C level in overweigh and obesity populations.