近红外光谱结合化学计量学的感冒灵颗粒半成品中蒙花苷含量检测研究
Study on the Content Determination of Linarin in the Semi-Finished Products of Ganmaoling Granules by Near Infrared Spec-troscopy Combined with Stoichiometry
DOI: 10.12677/HJMCe.2021.93013, PDF,   
作者: 麦 毅, 包彦宇, 吕洪亮, 陈沛鑫：华润三九医药股份有限公司，广东 深圳；王 钧, 李页瑞*：苏州泽达兴邦医药科技有限公司，江苏 苏州
关键词: 感冒灵颗粒；蒙花苷；近红外光谱技术；偏最小二乘法；过程质量控制；Ganmaoling Granules； Linarin； Near Infrared Spectroscopy； Partial Least Squares Method； Process Quality Control
摘要: 目的：本研究旨在建立近红外光谱法快速检测感冒灵颗粒半成品中蒙花苷含量的方法。方法：利用近红外光谱仪对感冒灵颗粒半成品样品进行扫描, 对其光谱进行预处理和波段选择, 并结合偏最小二乘法(partial least squares, PLS)建立浸出物含量快速无损检测方法。结果：所建立的模型的决定系数R为0.9428，交叉验证均方根差值为0.0115, 对验证集样品进行预测并统计分析, 预测值与真实值之间无显著差异(P > 0.05)。结论：所建立的模型准确度高, 适用于感冒灵颗粒半成品的蒙花苷含量的快速检测。
Abstract: Objective: The aim of this study was to establish a method for the rapid determination of linarin in the semi-finished products of ganmaoling granules by near infrared spectroscopy. Methods: The semi-finished samples of ganmaoling granules were scanned by near-infrared spectroscopy (NIR). The spectra of the samples were pretreated and the bands were selected. A method for rapid non-destructive determination of extract content was established by using partial least squares method (PLS). Results: The determination coefficient R of the established model was 0.9428, and the root mean square difference of cross-validation was 0.0115. The samples of the validation set were pre-dicted and statistically analyzed, and there was no significant difference between the predicted value and the true value (P > 0.05). Conclusion: The established model has high accuracy and is suitable for the rapid determination of the content of linarin in the semi-finished products of ganmaoling granules.
文章引用：麦毅, 包彦宇, 秋晖, 吕洪亮, 李红, 陈沛鑫, 王钧, 李页瑞. 近红外光谱结合化学计量学的感冒灵颗粒半成品中蒙花苷含量检测研究[J]. 药物化学, 2021, 9(3): 105-111. https://doi.org/10.12677/HJMCe.2021.93013

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