富硒黑木耳多糖降血糖的作用研究

Hypoglycemic Effect of Selenium Enriched Auricularia Auricula Polysaccharide

摘要: 目的：为研究富硒黑木耳多糖对降血糖作用的影响。方法：采用热水浸提法分别提取富硒黑木耳多糖和普通黑木耳多糖。按计量腹腔注射STZ使小鼠成功建立I型糖尿病的患病模型，后分7组，每天灌喂一定剂量的多糖溶液和盐酸二甲双胍溶液，共灌胃4周。30 d后，测定小鼠葡萄糖耐量。取小鼠血液保存，测定总胆固醇(TC)、甘油三酯(TG)、糖化血红蛋白(GHb)，取肾、脾、肝、心脏计算脏器系数，并进行数据分析。结果：富硒高剂量组降血糖效果略好于普通组，富硒高剂量组和普通高剂量组均能降低TC、TG、GHb值，富硒高剂量组和低剂量组的肝肾脏器系数与阳性对照组均没有显著性差异(p > 0.05)且高剂量组的脏器系数与阳性对照组接近。结论：富硒高剂量组对糖尿病小鼠模型具有有助于降血糖作用。

Abstract: Objective: To study the effect of selenium-enriched black fungus polysaccharides on lowering blood sugar. Method: The selenium-enriched black fungus polysaccharide and common black fungus polysaccharide were extracted separately by hot water extraction. According to the metered intraperitoneal injection of STZ, the mice successfully established the prevalence model of type 1 diabetes. They were divided into 7 groups and were fed a certain dose of polysaccharide solution and metformin hydrochloride solution every day for 4 weeks. After 30 days, the mice’s glucose tolerance was measured. The blood of the mice was taken and preserved, and then the total cholesterol (TC), triglycerides (TG) and glycosylated hemoglobin (GHb) were measured. We take the kidney, spleen, liver, and heart of the mouse to calculate the organ coefficients and analyze the data. Results: The selenium-enriched high-dose group had a slightly better blood sugar lowering effect than the ordinary group. Both the selenium-enriched high-dose group and the ordinary high-dose group could reduce the values of TC, TG, GHb, and the liver and kidney organ coefficients of the selenium-enriched high-dose group and low-dose group. There was no significant difference from the positive control group (p > 0.05), and the organ coefficient of the high-dose group was close to that of the positive control group. Conclusion: The high-dose selenium-enriched group has a beneficial effect on lowering blood sugar in diabetic mouse models.