近红外光谱快速分析银杏离心液中萜类内酯的含量
Rapid Analysis of Content of Terpene Lactones in Ginkgo Centrifugal Solution by Near Infrared Spectroscopy
DOI: 10.12677/HJMCe.2022.101005, PDF,   
作者: 王 军, 韦亚芳：上海上药杏灵科技药业股份有限公司，上海；黄家鹏, 王 钧：苏州泽达兴邦医药科技有限公司，江苏 苏州
关键词: 银杏离心液；萜类内酯；近红外光谱技术；偏最小二乘法；过程质量控制；Ginkgo Centrifugal Solution； Terpenoid Lactones； Near Infrared Spectroscopy； Partial Least Squares Method； Process Quality Control
摘要: 目的：建立近红外光谱法快速检测银杏离心液中萜类内酯含量的方法。方法：利用近红外光谱仪对银杏离心液样品进行扫描，对其光谱进行预处理和波段选择，并结合偏最小二乘法(partial least squares, PLS)建立萜类内酯含量快速无损检测方法。结果：所建立的模型的决定系数R为0.9177，交叉验证均方根差值为0.0335，对验证集样品进行预测并统计分析，预测值与真实值之间无显著差异(P > 0.05)。结论：所建立的模型准确度高，适用于银杏离心液中萜类内酯含量的快速检测。
Abstract: Objective: To establish a method for rapid determination of terpenoids in ginkgo centrifugal solu-tion by near infrared spectroscopy. Methods: NIR spectroscopy was used to scan the ginkgo centrif-ugal solution samples, and the spectra were pretreated and the bands were selected. A fast and non-destructive method for the determination of terpenoids was established by partial least squares (PLS) method. Results: The determination coefficients R of the established model were 0.9177, and the root mean square difference of cross-validation were 0.0335, respectively. There was no significant difference between the predicted value and the true value (P > 0.05) after the prediction and statistical analysis of the validation set samples. Conclusion: The established model has high accuracy and is suitable for the rapid determination of terpenoids in ginkgo centrifugal solution.
文章引用：王军, 韦亚芳, 黄家鹏, 王钧. 近红外光谱快速分析银杏离心液中萜类内酯的含量[J]. 药物化学, 2022, 10(1): 39-45. https://doi.org/10.12677/HJMCe.2022.101005

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