17例犬膀胱肿瘤的诊断及回顾性分析

Diagnosis and Retrospective Analysis of 17 Canine Bladder Tumors

摘要: 为探讨临床犬膀胱肿瘤的发病特点和诊断方法，本文以17例犬膀胱肿瘤样本为研究对象，统计分析样本来源动物的临床信息和检查结果，按流程制备石蜡切片后，显微镜下观察其组织排列特点和细胞异型性。结果显示17例膀胱肿瘤中15例为上皮组织来源的肿瘤(88.23%)，分别为良性的膀胱上皮乳头状瘤(3例)，恶性的膀胱移行上皮细胞癌(10例)和膀胱腺癌(2例)，良、恶性肿瘤比例为0.25:1；2例为间叶组织来源的肿瘤(11.77%)，分别为良性的平滑肌瘤与恶性的淋巴瘤，比例为1:1。研究证明临床犬膀胱肿瘤主要为上皮细胞来源，且恶性肿瘤发生率较高。由于犬膀胱肿瘤多伴发易误诊的炎症病变和泌尿系统症状，因此临床诊断的金标准仍然为组织病理学。

Abstract: In order to explore the clinical characters and diagnostic methods of canine bladder tumors, 17 canine bladder tumors specimens were collected in this study. Firstly, clinical information and examination results of the samples were analyzed, and then paraffin sections were prepared according to the procedure. Finally, the tissue arrangement and cell heterogeneity were observed under the microscope. Results found that 15 cases were bladder epithelial cell-derived tumors (88.23%), in which all of the benign tumors were bladder epithelial papilloma (3 cases), and malignant bladder epithelial cell tumors were bladder transitional epithelial cell carcinoma (10 cases) and bladder adenocarcinoma (2 cases). The ratio of benign to malignant was 0.25:1; and 2 cases were mesenchymal cell-derived tumors (11.77%), which were benign leiomyoma and malignant lymphoma in a ratio of 1:1. This results proved that clinical canine bladder tumors are mainly epithelial cell-derived, with higher incidence of malignant tumors. The gold standard of clinical diagnosis remains histopathological diagnosis, because canine bladder tumors are often with easily misdiagnosed inflammatory lesions and urinary symptoms.