生物制剂在儿童难治性哮喘中的应用研究进展
Research Progress on the Application of Biological Agents in Children with Refractory Asthma
DOI: 10.12677/ACM.2022.126766, PDF,    科研立项经费支持
作者: 秦凤媛, 舒 畅*:重庆医科大学附属儿童医院呼吸科/儿童发育疾病研究教育部重点实验室/国家儿童健康与疾病临床医学研究中心/儿童发育重大疾病国家国际科技合作基地/儿科学重庆市重点实验室,重庆
关键词: 难治性哮喘生物制剂儿童Refractory Asthma Biologics Children
摘要: 哮喘是一种常见的多种炎症性细胞参与的慢性气道炎症性疾病,发病率呈逐年增高的趋势。生物制剂是一种单克隆抗体,通过靶向结合炎症中的特定细胞因子及其受体,减轻哮喘炎症反应。难治性哮喘患儿经常性全身性使用类固醇激素副作用大,给家庭和社会带来沉重负担。研究表明,生物制剂可作为儿童难治性哮喘辅助治疗药物,能够改善患儿肺功能,提高患儿生活质量。本文就生物制剂在儿童难治性哮喘中应用最新临床研究作一综述。
Abstract: Asthma is a common chronic airway inflammatory disease involving a variety of inflammatory cells. The incidence is increasing year by year. A biologic is a monoclonal antibody that reduces the asth-matic inflammatory response by targeting specific cytokines and their receptors in inflammation. Frequent systemic use of steroids in children with refractory asthma has serious side effects and brings a heavy burden to the family and society. Studies have shown that biological agents can be used as adjuvant drugs for the treatment of children with refractory asthma, which can improve the lung function of children and the quality of life of children. This article reviews the latest clinical re-search on the application of biological agents in children with refractory asthma.
文章引用:秦凤媛, 舒畅. 生物制剂在儿童难治性哮喘中的应用研究进展[J]. 临床医学进展, 2022, 12(6): 5286-5293. https://doi.org/10.12677/ACM.2022.126766

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