广陈皮中多甲氧基黄酮类物质在抗氧化活性方面的临床应用研究
Clinical Study on Antioxidant Activity of Polymethoxy Flavonoids from Pericarpium citri
DOI: 10.12677/PI.2022.114043, PDF,   
作者: 刘慈斌*：广东鼎铭药业有限公司，广东 汕头 ；何伟源：汕头市中心医院心血管内科，广东 汕头
关键词: 广陈皮；多甲氧基黄酮类物质；抗氧化；应用；Tangerine Peel； Polymethoxy Flavonoids； Antioxidation； Application
摘要: 为研究广陈皮中多甲氧基黄酮类物质(PMFs)对血脂指标和抗氧化能力的影响，选择30名志愿者服用4周广陈皮后进行血清学检测表明，广陈皮对于提高血清中抗氧化酶SOD的水平有显著的作用(P < 0.05)，同时有降低丙二醛含量的趋势，表明多甲氧基黄酮类物质对于提高机体的抗氧能力有一定的作用。通过血清学检测对血脂的影响分析发现，广陈皮多甲氧基黄酮类物质可明显降低血清TC和LDL-C蛋白水平，对血清TG也有明显调节作用，同时还能增加高密度脂蛋白水平，发挥出降血脂的健康保健作用。PMFs可以调节机体的抗氧化能力，为PMFs在临床的广泛应用提供一定的理论基础。
Abstract: In order to study the effect of polymethoxy flavonoids (PMFs) in Pericarpium citri Reticulatae on blood lipid index and antioxidant capacity, 30 volunteers were selected to take Pericarpium citri Reticulatae for 4 weeks. The serological test showed that Pericarpium citri Reticulatae had a significant effect on increasing the level of antioxidant enzyme SOD in serum (p < 0.05), and had a trend to reduce the content of malondialdehyde, indicating that polymethoxy flavonoids had a certain effect on improving the antioxidant capacity of the body. Through the analysis of the influence of serological detection on blood lipids, it was found that the polymethoxy flavonoids of Pericarpium citri Reticulatae could significantly reduce the levels of serum TC and LDL-C protein, regulate serum TG, increase the level of high-density lipoprotein, and play a role in reducing blood lipids. PMFs can regulate the antioxidant capacity of the body, which provides a theoretical basis for the wide clinical application of PMFs.
文章引用：刘慈斌, 何伟源, 何伟强. 广陈皮中多甲氧基黄酮类物质在抗氧化活性方面的临床应用研究[J]. 药物资讯, 2022, 11(4): 335-339. https://doi.org/10.12677/PI.2022.114043

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