小淋巴细胞淋巴瘤伴EBV阳性弥漫大B细胞淋巴瘤老年病例分析并文献复习
Small Lymphocytic Lymphoma with EBV Positive Diffuse Large B-Cell Lymphoma in Elderly Patients and Literature Review: A Case Report and Literature Review
DOI: 10.12677/ACM.2022.12111535, PDF,   
作者: 马育硕, 赵 霞, 卞海艳*：青岛大学附属医院，山东 青岛
关键词: 淋巴瘤；Richter综合征；诊断；治疗；Lymphoma； Richter Syndrome； Diagnosis； Treatment
摘要: RS综合征在亚洲发病罕见，预后极差，中位生存期短。本文报告1例小淋巴细胞淋巴瘤向伴EBV阳性弥漫大B细胞淋巴瘤转化的老年病例临床资料，并结合相关文献复习分析其诊治经验。
Abstract: RS syndrome is rare in Asia, with poor prognosis and short median survival. This article reports the clinical data of a case of small lymphocytic lymphoma transformed into an EBV positive diffuse large B cell lymphoma in the elderly and analyzes its diagnosis and treatment experience in conjunction with relevant literature review.
文章引用：马育硕, 赵霞, 卞海艳. 小淋巴细胞淋巴瘤伴EBV阳性弥漫大B细胞淋巴瘤老年病例分析并文献复习[J]. 临床医学进展, 2022, 12(11): 10663-10667. https://doi.org/10.12677/ACM.2022.12111535

参考文献

[1] Swerdlow, S.H. (2008) WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. International Agency for Research on Cancer, Lyon.
[2] Tsimberidou, A.M. and Keating, M.J. (2005) Richter Syndrome: Biology, Incidence, and Therapeutic Strategies. Cancer, 103, 216-228. [Google Scholar] [CrossRef] [PubMed]
[3] Wang, Y., Tschautscher, M.A., Rabe, K.G., et al. (2020) Clinical Characteristics and Outcomes of Richter Transformation: Experience of 204 Pa-tients from a Single Center. Haematologica, 105, 765-773. [Google Scholar] [CrossRef] [PubMed]
[4] Tamar, T., Lev, S., Neta, G., et al. (2014) Hodgkin’s Variant of Richter Transformation in Chronic Lymphocytic Leukemia: A Retrospective Study from the Israeli CLL Study Group. Anticancer Research, 34, 785-790.
[5] Ekaterina, C., Andrea, R., Ivo, K., et al. (2013) Two Main Genetic Pathways Lead to the Transformation of Chronic Lymphocytic Leukemia to Richter Syndrome. Blood, 122, 2673-2682. [Google Scholar] [CrossRef] [PubMed]
[6] Parikh, S.A., Kay, N.E. and Shanafelt, T.D. (2014) How We Treat Richter Syndrome. Blood, 123, 1647-1657. [Google Scholar] [CrossRef] [PubMed]
[7] Eyre, T.A. and Schuh, A. (2017) An Update for Richter Syn-drome—New Directions and Developments. British Journal of Haematology, 178, 508-520. [Google Scholar] [CrossRef] [PubMed]
[8] Maddocks-Christianson, K., Slager, S.L., Zent, C.S., et al. (2007) Risk Factors for Development of a Second Lymphoid Malignancy in Patients with Chronic Lymphocytic Leukaemia. British Journal of Haematology, 139, 398-404. [Google Scholar] [CrossRef] [PubMed]
[9] Apostolia-Maria, T., O’Brien, S., Khouri, I., et al. (2006) Clinical Outcomes and Prognostic Factors in Patients with Richter’s Syndrome Treated with Chemotherapy or Chemo-immunotherapy with or without Stem-Cell Transplantation. Journal of Clinical Oncology, 24, 2343-2351. [Google Scholar] [CrossRef] 
[10] Rossi, D., Cerri, M., Capello, D., et al. (2008) Biological and Clinical Risk Factors of Chronic Lymphocytic Leukaemia Transformation to Richter Syndrome. British Journal of Hae-matology, 142, 202-215. [Google Scholar] [CrossRef] [PubMed]
[11] De Paoli, F., et al. (2011) Predictive Markers and Driving Factors behind Richter Syndrome Development. Expert Review of Anticancer Therapy, 11, 433-442. [Google Scholar] [CrossRef] [PubMed]
[12] Ding, W., LaPlant, B.R., Call, T.G., et al. (2017) Pembrolizumab in Patients with CLL and Richter Transformation or with Relapsed CLL. Blood, 129, 3419-3427. [Google Scholar] [CrossRef] [PubMed]
[13] 佚名. 中国淋巴瘤合并HBV感染患者管理专家共识[J]. 中华血液学杂志, 2013, 34(11): 988-993.
[14] Thornton, P.D., et al. (2005) Richter’s Transformation of Chronic Lymphocytic Leukemia: The Possible Role of Fludarabine and the Epstein-Barr Virus in Its Pathogenesis. Leukemia Re-search, 29, 389-395. [Google Scholar] [CrossRef] [PubMed]
[15] 魏华萍. EB病毒感染对R-CHOP治疗弥漫大B细胞淋巴瘤影响的Meta分析[J]. 中国临床新医学, 2018, 11(9): 884-888.
[16] 张洪涛. 中国第一个获得美国FDA“突破性疗法”认证的抗癌新药, 到底好在哪?[J]. 科技导报, 2019, 37(11): 6-8.
[17] Song, Y., Zhou, K., Zou, D., et al. (2018) Safety and Activity of the Investigational Bruton Tyrosine Kinase Inhibitor Zanubrutinib (BGB-3111) in Patients with Mantle Cell Lymphoma from a Phase 2 Trial. Blood, 132, Article No. 148. [Google Scholar] [CrossRef] 

为你推荐