基于水凝胶的血管吻合器设计与实验研究

Design and Experimental Study of Vascular Stapler Based on Hydrogel

摘要: 研究基于水凝胶增强的椎动脉血管吻合器，并验证其可靠性。利用海藻酸钙水凝胶作为血管连接与防渗漏关键部件，分别设计了贴合式和袖套式水凝胶血管吻合器，运用ANSYS软件进行了流固耦合的有限元计算，最后进行了离体实验，对比分析两种吻合模型的血管的变形及壁面剪切应力分布、水凝胶的变形及应力应变分布和血管爆破压大小。在两种结构设计中血液流动均表现平稳，具有较好的吻合和粘合条件。其中袖套式吻合模型中水凝胶所受应力应变较小，分别为15.679 Pa，0.3%；爆破压测试中袖套式吻合血管所能承受的压力较正常血管相近，保持在1321.1 mmHg左右。研究表明，水凝胶材料在血管吻合器设计具有较好的潜在应用，对比不同结构设计，袖套式吻合方法较贴合式吻合方法更加可靠。

Abstract: To study the vertebral artery vascular stapler based on hydrogel enhancement and verify its relia-bility. Calcium alginate hydrogel was used as the key component of vascular connection and leakage prevention. The fitting type and sleeve type hydrogel vascular stapler were designed respectively. The finite element calculation of fluid-structure coupling was carried out by ANSYS software. Finally, the in vitro experiment was carried out. The blood vessel deformation and wall shear stress distri-bution, hydrogel deformation and stress-strain distribution and vessel bursting pressure were compared and analyzed. The blood flow was stable in both structures with good anastomosis and adhesion conditions. In the sleeve anastomosis model, the stress and strain of hydrogels were smaller (15.679 Pa, 0.3%). In the burst pressure test, the pressure of the sleeve anastomotic vessel was similar to that of the normal vessel, and kept at about 1321.1 mmHg. Studies have shown that hydrogel materials have a good potential application in vascular stapler design. Compared with dif-ferent structural designs, the sleeve anastomosis method is more reliable than the fit anastomosis method.