海南地区系统性红斑狼疮患者中医证型与实验室指标的相关性研究

Study on the Correlation between TCM Syndrome Types and Laboratory Indexes in Patients with Systemic Lupus Erythematosus

摘要: 目的：探究海南地区系统性红斑狼疮中医证型和实验室指标之间的相关性。方法：收集2020年9月至2022年3月海南省人民医院风湿科SLE患者病例，分析SLE常见证型与临床实验室数据的相关性。结果：最终纳入247例SLE患者，4种证型，为热毒炽盛证、阴虚内热证、脾肾阳虚证、风湿热痹证。其中脾肾阳虚证临床最多见，其次是阴虚内热证、风湿热痹证、热毒炽盛证；热毒炽盛证的疾病活动评分最高，初诊患者多为阴虚内热证。脾肾阳虚证患者的HB均值显著低于阴虚内热证和风湿热痹证(P < 0.05)；脾肾阳虚证患者的血尿阳性率和尿蛋白阳性率显著高于热毒炽盛证、阴虚内热证和风湿热痹证(P < 0.05)。风湿热痹证的IgA水平显著高于阴虚内热证和脾肾阳虚证(P < 0.05)；脾肾阳虚证的IgG水平显著低于热毒炽盛证、阴虚内热证和风湿热痹证(P < 0.05)。结论：SLE中医证型和实验室检查结果之间存在一定相关性，为了解系统性红斑狼疮中医证候演变规律及防治该病提供参考。

Abstract: Objective: To explore the correlation between TCM Syndrome Types and laboratory indexes of sys-temic lupus erythematosus (SLE). Methods: SLE patients in rheumatology department of Hainan Provincial People’s Hospital from September 2020 to March 2022 were collected. The correlation between common syndrome types of SLE and clinical laboratory data was analyzed. Results: 247 patients with SLE were included in the study. There were 4 types of syndrome, including excessive heat toxin syndrome, Yin deficiency and internal heat syndrome, spleen kidney yang deficiency syndrome and rheumatism heat arthralgia syndrome. Spleen and kidney yang deficiency syndrome is the most common clinical syndrome, followed by Yin deficiency and internal heat syndrome, rheumatism heat arthralgia syndrome, and excessive heat toxin syndrome; The disease activity score of the hot toxin syndrome was the highest, and most of the newly diagnosed patients were Yin deficiency and internal heat syndrome. In the mean value comparison of Hb, spleen kidney yang de-ficiency syndrome was lower than Yin deficiency internal heat syndrome and rheumatism heat ar-thralgia syndrome (P < 0.05); the positive rate of hematuria and urine protein in spleen kidney Yang deficiency syndrome was higher than that in hot toxin syndrome, Yin deficiency internal heat syndrome and rheumatism heat arthralgia syndrome (P < 0.05); the mean value of IgA in rheuma-tism heat arthralgia syndrome was higher than that in Yin deficiency internal heat syndrome and spleen kidney yang deficiency syndrome (P < 0.05); The mean value of IgG in spleen kidney yang deficiency syndrome was lower than that in heat toxin excess syndrome, Yin deficiency and internal heat syndrome, and rheumatism heat arthralgia syndrome (P < 0.05). Conclusion: There is a certain correlation between the TCM syndrome types of SLE and the results of laboratory examination, which provides a reference for further understanding the evolution law of TCM syndrome of sys-temic lupus erythematosus and preventing and treating the disease.