2型糖尿病患者血清FNDC5水平与左室舒张功能参数的关系

Relationship between Left Ventricular Diastolic Function and Serum Fibronectin Type III-Domain Containing Protein 5 (FNDC5) in Type 2 Diabetes Mellitus

摘要: 目的：观察2型糖尿病(T2DM)患者血清III型纤维蛋白结构域结合蛋白5 (FNDC5)水平与正常组的差异，以及T2DM患者血清FNDC5水平与左心室舒张功能的关系，探讨其临床应用价值。方法：选取T2DM患者158例作为实验组，非2型糖尿病患者作为对照组37例。采用酶联免疫吸附试验(ELISA)检验患者血清FNDC5水平。结果：T2DM患者血清FNDC5水平较正常组血清FNDC5水平明显降低(P < 0.001)。相关系数分析显示，2型糖尿病患者中血清FNDC5浓度与E峰呈正相关(r = 0.363, P = 0.005)，与E/A呈正相关(r = 0.291, P = 0.006)，与E/二尖瓣瓣环间隔e’呈负相关(r = −0.495, P = 0.000)，与E/二尖瓣瓣环侧壁e’呈负相关(r = −0.595, P = 0.000)，与E/平均e’呈负相关(r = −0.610, P = 0.000)，与左房前后径呈负相关(r = −0.304, P = 0.002)。多元有序Logistic回归分析，结果显示年龄及FNDC5水平为影响左室充盈压的独立影响因素(P < 0.05)。结论：2型糖尿病患者血清FNDC5水平显著降低，低水平FNDC5可能与2型糖尿病患者早期左室舒张功能障碍有关。

Abstract: Objective: To observe the difference of the serum fibronectin type III-domain containing protein 5 (FNDC5) level between T2DM patients and normal group, and the relationship between the serum FNDC5 level and left ventricular diastolic function in T2DM patients and assess its clinical applica-tion. Method: A total of 158 T2DM patients were selected as experimental group. 37 non-T2DM pa-tients were selected as control group. Serum FNDC5 levels were detected by enzyme-linked im-munosorbent assay (ELISA). Result: The Serum FNDC5 levels in T2DM patients were significantly lower than that in control group (P < 0.001). There was a positive correlation between the serum FNDC5 level and the E peak (r = 0.363, P = 0.005) in patients with type 2 diabetes. There was a posi-tive correlation between the serum FNDC5 level and the E/A (r = 0.291, P = 0.006) in patients with type 2 diabetes. There was a negative correlation between the serum FNDC5 level and the E/mitral annulus septum e’ (r = -0.495, P = 0.000), a negative correlation between the serum FNDC5 level and the E/lateral wall of mitral annulus e’ (r = -0.595, P = 0.000), a negative correlation between the serum FNDC5 level and the E/e’ (r = -0.610, P = 0.000), and a negative correlation between the se-rum FNDC5 level and the diameter of the left atriumin (r = -0.304, P = 0.002) in the patients with type 2 diabetes. The multiple ordered Logistic regression analysis shows that age and the serum FNDC5 level are independent influencing factors for left ventricular filling pressure (P < 0.05). Con-clusions: The serum FNDC5 levels are significantly decreased in patients with type 2 diabetes mellitus, and the low levels of serum FNDC5 may be associated with early left ventricular diastolic dysfunction in patients with type 2 diabetes mellitus.