老年肱骨近端骨折的治疗进展
Advances in the Treatment of Proximal Hu-meral Fractures in the Elderly
DOI: 10.12677/ACM.2023.134926, PDF,   
作者: 范 龙, 金鹏宇, 张 杰:青岛大学青岛医学院,山东 青岛 ;孟 晔*:康复大学青岛医院(青岛市市立医院),山东 青岛
关键词: 肱骨骨折骨质疏松内固定关节置换Humeral Fracture Osteoporosis Internal Fixation Joint Replacement
摘要: 肱骨近端骨折是临床常见的老年骨质疏松性骨折,多数无明显移位的肱骨近端骨折的老年患者接受保守治疗效果良好。采用非手术方式治疗移位的肱骨近端骨折效果较差,常因畸形愈合而导致患者肩部疼痛和活动受限,严重削弱其生活自理能力,需行手术治疗。但是采用切开复位内固定治疗老年肱骨近端骨折仍面临以下困境:由于骨质疏松,骨折常合并压缩性骨缺损,解剖复位粉碎性骨折难以实现;常见内固定器械无法维持骨质疏松性骨折复位至愈合。目前对于移位的老年肱骨近端骨折选择何种内固定治疗方式仍然缺乏共识。笔者通过复习新的指南及文献,论述老年肱骨近端骨折适宜的治疗策略。
Abstract: Proximal humeral fracture is a common osteoporotic fracture in the elderly. Most elderly patients without significant displaced proximal humeral fractures receive good results with conservative treatment. Non-operative treatment of displaced proximal humeral fractures is less effective and often results in shoulder pain and limited mobility due to deformity healing, which severely impairs the patient’s ability to care for himself and requires surgical treatment. However, the treatment of displaced proximal humeral fractures by incisional internal fixation still faces the following dilem-mas: due to osteoporosis, fractures are often combined with compression bone defects, and ana-tomical reduction of comminuted fractures is difficult to achieve; common internal fixation devices are unable to maintain osteoporotic fractures until they heal. There is still a lack of consensus on the choice of internal fixation treatment for displaced proximal humeral fractures in the elderly. By reviewing new guidelines and literature, the author discusses the appropriate treatment strategy for proximal humeral fractures in the elderly.
文章引用:范龙, 金鹏宇, 张杰, 孟晔. 老年肱骨近端骨折的治疗进展[J]. 临床医学进展, 2023, 13(4): 6610-6622. https://doi.org/10.12677/ACM.2023.134926

参考文献

[1] Passaretti, D., Candela, V., Sessa, P., et al. (2017) Epidemiology of Proximal Humeral Fractures: A Detailed Survey of 711 Patients in a Metropolitan Area. Journal of Shoulder and Elbow Surgery, 26, 2117-2124. [Google Scholar] [CrossRef] [PubMed]
[2] Omid, R., Trasolini, N.A., Stone, M.A., et al. (2021) Principles of Locking Plate Fixation of Proximal Humerus Fractures. Journal of the American Academy of Orthopaedic Surgeons, 29, e523-e535. [Google Scholar] [CrossRef
[3] Palvanen, M., Kannus, P., Niemi, S., et al. (2006) Update in the Epidemiology of Proximal Humeral Fractures. Clinical Orthopaedics and Related Research®, 442, 87-92. [Google Scholar] [CrossRef] [PubMed]
[4] Court-Brown, C.M. and Caesar, B. (2006) Epidemiolo-gy of Adult Fractures: A Review. Injury, 37, 691-697. [Google Scholar] [CrossRef] [PubMed]
[5] 马明太, 付中国. 肱骨近端骨折治疗的决策分析[J]. 中国骨与关节杂志, 2019, 8(7): 482-485.
[6] Rangan, A., Handoll, H., Brealey, S., et al. (2015) Surgical vs Nonsurgical Treatment of Adults with Displaced Fractures of the Proximal Humerus: The PROFHER Randomized Clinical Trial. JAMA, 313, 1037-1047. [Google Scholar] [CrossRef] [PubMed]
[7] Moatshe, G., Marchetti, D.C., Chahla, J., et al. (2018) Qualitative and Quantitative Anatomy of the Proximal Humerus Muscle Attachments and the Axillary Nerve: A Cadaveric Study. Ar-throscopy, 34, 795-803. [Google Scholar] [CrossRef] [PubMed]
[8] 刘蓬然, 申澳, 吕静, 等. 三维立体可视化测量国人肱骨近端解剖学参数[J]. 中国临床解剖学杂志, 2022, 40(1): 10-16.
[9] Iannotti, J.P., Gabriel, J.P., Schneck, S.L., et al. (1992) The Normal Glenohumeral Relationships. An Anatomical Study of One Hundred and Forty Shoulders. The Journal of Bone and Joint Surgery. American Volume, 74, 491-500. [Google Scholar] [CrossRef
[10] Robertson, D.D., Yuan, J., Bigliani, L.U., et al. (2000) Three-Dimensional Analysis of the Proximal Part of the Humerus: Relevance to Arthroplasty. The Journal of Bone and Joint Surgery. American Volume, 82, 1594-1602. [Google Scholar] [CrossRef] [PubMed]
[11] Hertel, R., Knothe, U. and Ballmer, F.T. (2002) Geome-try of the Proximal Humerus and Implications for Prosthetic Design. Journal of Shoulder and Elbow Surgery, 11, 331-338. [Google Scholar] [CrossRef] [PubMed]
[12] Hettrich, C.M., Boraiah, S., Dyke, J.P., et al. (2010) Quantitative Assessment of the Vascularity of the Proximal Part of the Humerus. The Journal of Bone and Joint Surgery. American Volume, 92, 943-948. [Google Scholar] [CrossRef
[13] 吴晓明, 王蕾. 浅谈髓内钉治疗肱骨近端骨折的利弊[J]. 中华肩肘外科电子杂志, 2016, 4(4): 193-198.
[14] Wendt, K.W., Jaeger, M., Verbruggen, J., et al. (2021) ESTES Recommen-dations on Proximal Humerus Fractures in the Elderly. European Journal of Trauma and Emergency Surgery, 47, 381-395. [Google Scholar] [CrossRef] [PubMed]
[15] Neer, C.S. (1970) Displaced Proximal Humeral Fractures. I. Classification and Evaluation. The Journal of Bone and Joint Surgery. American Volume, 52, 1077-1089. [Google Scholar] [CrossRef
[16] Marongiu, G., Leinardi, L., Congia, S., et al. (2020) Re-liability and Reproducibility of the New AO/OTA 2018 Classification System for Proximal Humeral Fractures: A Com-parison of Three Different Classification Systems. Journal of Orthopaedics and Traumatology, 21, 4. [Google Scholar] [CrossRef] [PubMed]
[17] Iordens, G.I., Mahabier, K.C., Buisman, F.E., et al. (2016) The Reliability and Reproducibility of the Hertel Classification for Comminuted Proximal Humeral Fractures Compared with the Neer Classification. Journal of Orthopaedic Science, 21, 596-602. [Google Scholar] [CrossRef] [PubMed]
[18] Hertel, R., Hempfing, A., Stiehler, M., et al. (2004) Predictors of Humeral Head Ischemia after Intracapsular Fracture of the Proximal Humerus. Journal of Shoulder and Elbow Surgery, 13, 427-433. [Google Scholar] [CrossRef] [PubMed]
[19] Komadina, R. (2008) Hip, Osteoporosis: New Paradigm. European Journal of Trauma and Emergency Surgery, 34, 163-170. [Google Scholar] [CrossRef] [PubMed]
[20] Helfen, T., Sprecher, C.M., Eberli, U., et al. (2017) High-Resolution Tomography-Based Quantification of Cortical Porosity and Cortical Thickness at the Surgical Neck of the Humerus during Aging. Calcified Tissue International, 101, 271-279. [Google Scholar] [CrossRef] [PubMed]
[21] Wong, C.P., Gani, L.U. and Chong, L.R. (2020) Dual-Energy X-Ray Absorptiometry Bone Densitometry and Pitfalls in the Assessment of Osteoporosis: A Primer for the Practicing Clinician. Archives of Osteoporosis, 15, 135. [Google Scholar] [CrossRef] [PubMed]
[22] Hanson, B., Neidenbach, P., De Boer, P., et al. (2009) Function-al Outcomes after Nonoperative Management of Fractures of the Proximal Humerus. Journal of Shoulder and Elbow Surgery, 18, 612-621. [Google Scholar] [CrossRef] [PubMed]
[23] Gaebler, C., Mcqueen, M.M. and Court-Brown, C.M. (2003) Mini-mally Displaced Proximal Humeral Fractures: Epidemiology and Outcome in 507 Cases. Acta Orthopaedica Scandinavi-ca, 74, 580-585. [Google Scholar] [CrossRef
[24] Bell, J.E., Leung, B.C., Spratt, K.F., et al. (2011) Trends and Variation in Incidence, Surgical Treatment, and Repeat Surgery of Proximal Humeral Fractures in the Elderly. The Jour-nal of Bone and Joint Surgery. American Volume, 93, 121-131. [Google Scholar] [CrossRef
[25] Schliemann, B., Wähnert, D., Theisen, C., et al. (2015) How to Enhance the Stability of Locking Plate Fixation of Proximal Humerus Fractures? An Overview of Current Biomechanical and Clinical Data. Injury, 46, 1207-1214. [Google Scholar] [CrossRef] [PubMed]
[26] Sohn, H.S., Jeon, Y.S., Lee, J., et al. (2017) Clinical Comparison between Open Plating and Minimally Invasive Plate Osteosynthesis for Displaced Proximal Humeral Fractures: A Pro-spective Randomized Controlled Trial. Injury, 48, 1175-1182. [Google Scholar] [CrossRef] [PubMed]
[27] Boileau, P., D’ollonne, T., Bessière, C., et al. (2019) Displaced Humeral Surgical Neck Fractures: Classification and Results of Third-Generation Percutaneous Intramedullary Nailing. Journal of Shoulder and Elbow Surgery, 28, 276-287. [Google Scholar] [CrossRef] [PubMed]
[28] Brouwer, M.E., Reininga, I.H.F., El Moumni, M., et al. (2019) Outcomes of Operative and Nonoperative Treatment of 3- and 4-Part Proximal Humeral Fractures in Elderly: A 10-Year Retrospective Cohort Study. European Journal of Trauma and Emergency Surgery, 45, 131-138. [Google Scholar] [CrossRef] [PubMed]
[29] Sproul, R.C., Iyengar, J.J., Devcic, Z., et al. (2011) A Systematic Review of Locking Plate Fixation of Proximal Humerus Fractures. Injury, 42, 408-413. [Google Scholar] [CrossRef] [PubMed]
[30] 李波, 熊文峰, 张世民. 锁定钢板治疗肱骨近端骨折中螺钉穿透关节面的研究进展[J]. 中国修复重建外科杂志, 2021, 35(4): 403-408.
[31] Osterhoff, G., Hoch, A., Wanner, G.A., et al. (2012) Calcar Comminution as Prognostic Factor of Clinical Outcome after Locking Plate Fixation of Proxi-mal Humeral Fractures. Injury, 43, 1651-1656. [Google Scholar] [CrossRef] [PubMed]
[32] Gardner, M.J., Weil, Y., Barker, J.U., et al. (2007) The Im-portance of Medial Support in Locked Plating of Proximal Humerus Fractures. Journal of Orthopaedic Trauma, 21, 185-191. [Google Scholar] [CrossRef
[33] Shin, M.J., Kim, H., Kim, D.M., et al. (2021) Role of Inferomedial Supporting Screws for Secondary Varus Deformity in Non-Osteoporotic Proximal Humerus Fracture: A Biomechanical Study. Archives of Orthopaedic and Trauma Surgery, 141, 1517-1523. [Google Scholar] [CrossRef] [PubMed]
[34] Padegimas, E.M., Zmistowski, B., Lawrence, C., et al. (2017) Defining Optimal Calcar Screw Positioning in Proximal Humerus Fracture Fixation. Journal of Shoulder and Elbow Surgery, 26, 1931-1937. [Google Scholar] [CrossRef] [PubMed]
[35] Flatow, E.L. (2016) Proximal Humeral Fractures: Is Some Varus Acceptable? Commentary on an Article by Marc Schnetzke, MD, et al.: “Quality of Reduction Influences Outcome after Locked-Plate Fixation of Proximal Humeral Type-C Fractures”. The Journal of Bone and Joint Surgery. American Vol-ume, 98, e97. [Google Scholar] [CrossRef
[36] Gardner, M.J., Boraiah, S., Helfet, D.L., et al. (2008) Indirect Medial Reduction and Strut Support of Proximal Humerus Fractures Using an Endosteal Implant. Journal of Orthopaedic Trauma, 22, 195-200. [Google Scholar] [CrossRef
[37] Lee, S.H., Han, S.S., Yoo, B.M., et al. (2019) Outcomes of Locking Plate Fixation with Fibular Allograft Augmentation for Proximal Humeral Fractures in Osteoporotic Patients: Comparison with Locking Plate Fixation Alone. The Bone & Joint Journal, 101-b, 260-265. [Google Scholar] [CrossRef
[38] He, Y., Zhang, Y., Wang, Y., et al. (2017) Biomechanical Evaluation of a Novel Dualplate Fixation Method for Proximal Humeral Fractures without Medial Support. Journal of Orthopaedic Surgery and Research, 12, 72. [Google Scholar] [CrossRef] [PubMed]
[39] Theopold, J., Marquas, B., Fakler, J., et al. (2016) The Bicipital Groove as a Landmark for Reconstruction of Complex Proximal Humeral Fractures with Hybrid Double Plate Osteo-synthesis. BMC Surgery, 16, 10. [Google Scholar] [CrossRef] [PubMed]
[40] Park, S.G. and Ko, Y.J. (2019) Medial Buttress Plating for Hu-merus Fractures with Unstable Medial Column. Journal of Orthopaedic Trauma, 33, e352-e359. [Google Scholar] [CrossRef
[41] Choi, S., Kang, H. and Bang, H. (2014) Technical Tips: Dualplate Fixation Technique for Comminuted Proximal Humerus Fractures. Injury, 45, 1280-1282. [Google Scholar] [CrossRef] [PubMed]
[42] Foruria, A.M., Martinez-Catalan, N., Valencia, M., et al. (2021) Proximal Humeral Fracture Locking Plate Fixation with Anatomic Reduction, and a Short-and-Cemented-Screws Con-figuration, Dramatically Reduces the Implant Related Failure Rate in Elderly Patients. JSES International, 5, 992-1000. [Google Scholar] [CrossRef] [PubMed]
[43] Dilisio, M.F., Nowinski, R.J., Hatzidakis, A.M., et al. (2016) In-tramedullary Nailing of the Proximal Humerus: Evolution, Technique, and Results. Journal of Shoulder and Elbow Sur-gery, 25, e130-e138. [Google Scholar] [CrossRef] [PubMed]
[44] Giannoudis, P.V., Xypnitos, F.N., Dimitriou, R., et al. (2012) Inter-nal Fixation of Proximal Humeral Fractures Using the Polarus Intramedullary Nail: Our Institutional Experience and Re-view of the Literature. Journal of Orthopaedic Surgery and Research, 7, 39. [Google Scholar] [CrossRef
[45] Von Rüden, C., Trapp, O., Hierholzer, C., et al. (2015) Intramedul-lary Nailing vs. Locking Plate Osteosynthesis in Proximal Humeral Fractures: Long-Term Outcome. Unfallchirurg, 118, 686-692. [Google Scholar] [CrossRef] [PubMed]
[46] Sosef, N., Van Leerdam, R., Ott, P., et al. (2010) Minimal Inva-sive Fixation of Proximal Humeral Fractures with an Intramedullary Nail: Good Results in Elderly Patients. Archives of Orthopaedic and Trauma Surgery, 130, 605-611. [Google Scholar] [CrossRef] [PubMed]
[47] Stedtfeld, H.W. and Mittlmeier, T. (2007) Fixation of Proximal Humeral Fractures with an Intramedullary Nail: Tipps and Tricks. European Journal of Trauma and Emergency Surgery, 33, 367-374. [Google Scholar] [CrossRef] [PubMed]
[48] Hessmann, M.H., Nijs, S., Mittlmeier, T., et al. (2012) Internal Fixation of Fractures of the Proximal Humerus with the MultiLoc Nail. Operative Orthopädie und Traumatologie, 24, 418-431. [Google Scholar] [CrossRef] [PubMed]
[49] Wu, L., Jiang, Y., Cao, X., et al. (2021) Efficacies and Complications of Internal Fixations with PHILOS Plate and Intramedullary Multiloc(®) Nails in the Surgical Treatment of Proximal Humerus Fractures. American Journal of Translational Research, 13, 11786-11796.
[50] 高峰, 王秀会, 周小小, 等. 交锁髓内钉与锁定钢板内固定治疗Neer 2、3部分肱骨近端骨折疗效比较[J]. 中国骨与关节损伤杂志, 2017, 32(7): 702-705.
[51] Wang, G., Mao, Z., Zhang, L., et al. (2015) Meta-Analysis of Locking Plate versus In-tramedullary Nail for Treatment of Proximal Humeral Fractures. Journal of Orthopaedic Surgery and Research, 10, 122. [Google Scholar] [CrossRef] [PubMed]
[52] Nijs, S. and Broos, P. (2009) Outcome of Shoulder Hemiarthro-plasty in Acute Proximal Humeral Fractures: A Frustrating Meta-Analysis Experience. Acta Orthopaedica Belgica, 75, 445-451.
[53] Boileau, P., Krishnan, S.G., Tinsi, L., et al. (2002) Tuberosity Malposition and Migration: Reasons for Poor Outcomes after Hemiarthroplasty for Displaced Fractures of the Proximal Humerus. Journal of Shoulder and Elbow Surgery, 11, 401-412. [Google Scholar] [CrossRef] [PubMed]
[54] Borowsky, K.A., Prasad, V.R., Wear, L.J., et al. (2013) Is Failure of Tuberosity Suture Repair in Hemi-Arthroplasty for Fracture Mechanical? Journal of Shoulder and Elbow Surgery, 22, 971-978. [Google Scholar] [CrossRef] [PubMed]
[55] Lambert, S.M. (2018) Ischaemia, Healing and Outcomes in Proximal Humeral Fractures. EFORT Open Reviews, 3, 304-315. [Google Scholar] [CrossRef] [PubMed]
[56] Chalmers, P.N., Slikker, W., Mall, N.A., et al. (2014) Reverse Total Shoulder Arthroplasty for Acute Proximal Humeral Fracture: Comparison to Open Reduction-Internal Fixation and Hemiarthroplasty. Journal of Shoulder and Elbow Surgery, 23, 197-204. [Google Scholar] [CrossRef] [PubMed]
[57] Brorson, S., Salomonsson, B., Jensen, S.L., et al. (2017) Revision after Shoulder Replacement for Acute Fracture of the Proximal Humerus. Acta Orthopaedica, 88, 446-450. [Google Scholar] [CrossRef] [PubMed]
[58] Visser, C.P., Coene, L.N., Brand, R., et al. (2001) Nerve Lesions in Proximal Humeral Fractures. Journal of Shoulder and Elbow Surgery, 10, 421-427. [Google Scholar] [CrossRef] [PubMed]
[59] Werner, B.S., Daggett, M., Carrillon, Y., et al. (2015) Evaluation of Lengthening in Reverse Shoulder Arthroplasty Comparing X-Rays and Computerised Tomography. International Or-thopaedics, 39, 2389-2394. [Google Scholar] [CrossRef] [PubMed]