circRNA在胰腺癌中的研究进展

Research Progress of circRNA in Pancreatic Cancer

摘要: 胰腺癌是一种高度致死的癌症类型，目前各种针对胰腺癌的治疗手段效果十分有限，其预后通常很差，因此，寻找新的治疗策略为改善胰腺癌患者的总体生存期至关重要。近年来，circRNA作为一类相对较新的RNA分子，其具有稳定性和广泛表达、功能多样等特点，众多研究显示circRNA在肿瘤与正常组织之间存在异常表达，并通过调控基因表达以及多种信号通路等作用机制，在肿瘤细胞的增殖、转移、耐药、免疫等生物学过程中扮演了重要的角色，成为肿瘤领域的研究热点之一。在胰腺癌的研究中，关于circRNA相关的研究也取得了一些进展，许多研究结果揭示了在胰腺癌的发生和发展中circRNA发挥了重要的调控作用。本综述对circRNA在胰腺癌领域近几年来的研究进展进行总结归纳，为胰腺癌的诊断与治疗提供新的见解。

Abstract: Pancreatic cancer is a highly lethal malignant tumor, and the current therapeutic approaches for pancreatic cancer have very limited effects, and its prognosis is usually poor, therefore, it is crucial to find new therapeutic strategies to improve the overall survival of pancreatic cancer patients. In recent years, circRNA, as a relatively new class of RNA molecules, has the characteristics of stability and wide expression, and diverse functions. Numerous studies have shown that circRNA is aber-rantly expressed between tumors and normal tissues, and plays an important role in the biological processes of tumor cell proliferation, metastasis, drug resistance, and immunity by regulating gene expression and various signaling pathways. It has become one of the hotspots of research in the field of oncology. In the study of pancreatic cancer, some progress has been made on circR-NA-related studies, and many findings have revealed that circRNA plays an important regulatory role in the development and progression of pancreatic cancer. This review summarizes the research progress of circRNA in the field of pancreatic cancer in recent years and provides new insights for the diagnosis and treatment of pancreatic cancer.