六堡茶对胶原诱导类风湿性关节炎DBA/1小鼠肠道菌群的影响

Effects of Liupao Tea Ingredients on Intestinal Microflora in Collagen Induced Arthritis DBA/1 Mice

摘要: 为探明六堡茶对类风湿性关节炎模型小鼠肠道菌群结构的影响，以牛II型胶原蛋白注射到DBA/1小鼠尾部建立类风湿性关节炎模型，分别给予六堡茶提取物、没食子酸灌胃治疗。结果表明，六堡茶和没食子酸都能够改善模型小鼠肠道菌群紊乱，六堡茶增加小鼠模型肠道中Alloprevotella、Muribaculaceae和Alistipes丰度，降低Colidextribacter、Lachnospiraceae_NK4A136_group、Lachnoclostridium和Lactobacillus的丰度，没食子酸增加Muribaculaceae、Clostridia_UCG-014和Alloprevotella的丰度，降低Lachnospiraceae_NK4A136_group、Lachnospiraceae_UCG-006和Lachnoclostridium的丰度。六堡茶和没食子酸能够显著改善类风湿关节炎小鼠肠道菌群的结构。

Abstract: To investigate the effect of ingredients from Liupao tea on the gut microbiota structure of collagen induced arthritis models, rheumatoid arthritis model was established by injecting bovine type II collagen into the tail of DBA/1 mice, and treated with Liupao tea extracts and gallic acid by gavage. Both Liupao tea and gallic acid can ameliorate intestinal microbiota disorder. Liupao tea increases the abundance of Alloprevotella, Muribaculaceae, and Alistipes in the intestine of a mouse model, while reducing the abundance of Colidextribacter, Lachnospiraceae_NK4A136_group, Lachno-clostridium, and Lactobacillus, with gallic acid increasing the abundance of Muribaculaceae, Clostridia_UCG-014 and Alloprevotella, reducing the abundance of Lachnospiraceae_NK4A136_group, Lachnospiraceae_UCG-006and Lachnoclostridium. Both of Liupao tea and gallic acid can certainly correct intestinal microbiota disorders. The ingredients of Liupao tea and gallic acid can significantly improve the structure of intestinal microbiota in mice with rheumatoid arthritis.