外泌体miRNA-126对缺血性脑卒中合并代谢相关脂肪性肝病患者的相关性研究

Correlation Study of Exosome miRNA-126 in Patients with Metabolic Related Fatty Liver Disease after Ischemic Stroke

摘要: 脑卒中(cerebral stroke)又称为“中风”、“脑血管意外”，是全球第二大死亡原因及第三大致残原因。根据临床表现和病因分为：缺血性卒中和出血性卒中，前者约占全球所有卒中的71%。代谢相关脂肪性肝病(metabolic related fatty liver disease, MAFLD)曾用名为非酒精性脂肪性肝病(NAFLD)，已经取代病毒性肝炎，成为我国慢性肝病的第一大病因。MAFLD作为多系统代谢功能紊乱疾病，可通过代谢相关的多种机制增加2型糖尿病(T2DM)、缺血性脑卒中和心血管疾病的风险。近年来的研究以外泌体的物质构成、运输、细胞间通讯多个功能为出发点，为临床疾病诊断及预后、治疗靶点提供了新手段。外泌体天然存在于各类型体液中，也可被所有类型细胞分泌，目前对外泌体的探究趋势已经从集中于肿瘤源性转变至对自身免疫性疾病、代谢疾病和缺血性疾病等非肿瘤性疾病的研究。外泌体的高度特异性和敏感性，使其可以作为一种疾病早期非侵入性新型诊断指标，本文就外泌体miRNA-126与缺血性脑卒中合并MAFLD患者的相关性作一综述。

Abstract: Cerebral Stroke, also known as “Stroke” and “Cerebrovascular Accident”, is the second leading cause of death and the third leading cause of disability in the world. According to clinical manifestations and etiology, cerebral stroke is divided into ischemic stroke and hemorrhagic stroke, the former is more common, accounting for about 71% of all strokes worldwide. Metabolic related fatty liver dis-ease (MAFLD) was once known as non-alcoholic fatty liver disease (NAFLD). The prevalence has re-placed the viral hepatitis, and become the first big cause of chronic liver disease. MAFLD is a multi-system metabolic disorder that increases the risk of type 2 diabetes mellitus (T2DM), ischemic stroke, and cardiovascular disease through multiple metabolism-related mechanisms. In recent years, the study of exosome material composition, transport, and cellular communication functions has provided a new means for clinical disease diagnosis, prognosis, and therapeutic targets. Exo-somes naturally exist in all types of body fluids and can be secreted by all types of cells. Currently, the research trend of exosomes has shifted from focusing on tumor-derived diseases to non-neoplastic diseases such as autoimmune diseases, metabolic diseases and ischemic diseases. Because of their high specificity and sensitivity, exosomes can be used as a new non-invasive diag-nostic indicator for early disease. This article reviews the correlation between exosomes miR-NA-126 and patients with ischemic stroke complicated with MAFLD.