血清LYVE1与类风湿性关节炎的相关性分析

Correlation Analysis between Serum LYVE1 and Rheumatoid Arthritis

摘要: 目的：探究血清中淋巴管内皮透明质酸受体-1 (LYVE1)与类风湿性关节炎(RA)红细胞沉降率(ESR)以及RA相关血清标志物的相关性。方法：收集类风湿性关节炎、骨关节炎(OA)与健康体检者全血各10例，分别检测全血标本的红细胞沉降率以及血清中类风湿因子(RF)、抗循环瓜氨酸肽(Anti-CCP)抗体、C-反应蛋白(CRP)、LYVE1含量。通过泊松分布(Poisson distribution)模型分析血清中的LYVE1与其余血清学指标的相关性。结果：RA患者血清中LYVE1含量明显低于OA患者与健康体检者，差异具有统计学意义(p < 0.05)。RA患者血清中的LYVE1与ESR、RF、Anti-CCP抗体、CRP呈负相关。结论：LYVE1或许可以作为一种全新的血清标志物用于临床诊断RA与评估RA的进展。

Abstract: Objective: To explore the correlation between serum lymphatic endothelial hyaluronic acid recep-tor-1 (LYVE1) and rheumatoid arthritis (RA) erythrocyte sedimentation rate (ESR) and RA-related serum markers. Methods: Whole blood samples were collected from 10 cases, each of rheumatoid arthritis, osteoarthritis (OA), and healthy subjects. The ESR was measured for each sample. Subse-quently, serum was collected and the levels of rheumatoid factor (RF), anti-circulating citrullinated peptide (Anti-CCP) antibodies, C-reactive protein (CRP), and LYVE1 were measured. The correlation between LYVE1 in serum and other serological indicators was analyzed through the Poisson distri-bution model. Results: The serum LYVE1 content of RA patients was significantly lower than that of OA patients and healthy subjects, and the difference was statistically significant (p < 0.05). LYVE1 in the serum of RA patients was negatively correlated with ESR, RF, Anti-CCP antibodies and CRP. Con-clusion: LYVE1 may serve as a novel serum biomarker for clinical diagnosis and evaluation of RA progression.