虾青素的生物活性研究进展
Research Progress on Biological Activities of Astaxanthin
DOI: 10.12677/HJMCe.2024.121007, PDF,    科研立项经费支持
作者: 蒋维维, 孙 琼, 全海燕, 单志芳*:湖南环境生物职业技术学院医药技术学院,湖南 衡阳
关键词: 虾青素抗氧化性抗炎生物活性Astaxanthin Antioxidant Anti-Inflammation Biological Activities
摘要: 虾青素属于类胡萝卜素中的叶黄素类,是天然的抗氧化剂。虾青素具有抗氧化,抗炎、抗癌以及调节血糖等多种生理活性,因而广泛应用于食品、制药等领域。本文主要对虾青素的来源、体内代谢和生物活性及其作用机制进行综述,为虾青素后期相关研究与开发应用提供理论依据。
Abstract: Astaxanthin (ATX) is a xanthophyll carotenoid and belongs to a natural antioxidant. ATX exhibits various physiological activities, such as antioxidant, anti-inflammation, anti-cancer, regulation of blood suger and so on, thereby widely applied to food, medicine. This review summarizes the source, metabolism and biological activities of ATX, and its related mechanisms, aims to provide the theoretical basis for research and comprehensive utilization of ATX.
文章引用:蒋维维, 孙琼, 全海燕, 单志芳. 虾青素的生物活性研究进展[J]. 药物化学, 2024, 12(1): 51-60. https://doi.org/10.12677/HJMCe.2024.121007

参考文献

[1] Ambati, R.R., Phang, S.M., Ravi, S. and Aswathanarayana, R.G. (2014) Astaxanthin: Sources, Extraction, Stability, Bi-ological Activities and Its Commercial Applications—A Review. Marine Drugs, 12, 128-152. [Google Scholar] [CrossRef] [PubMed]
[2] Lim, K.C., Yusoff, F.M., Shariff, M. and Kamarudin, M.S. (2018) Astaxanthin as Feed Supplement in Aquatic Animals. Reviews in Aquaculture, 10, 738-773. [Google Scholar] [CrossRef
[3] Kim, Y.E., Matter, I.A., Lee, N., et al. (2020) Enhancement of Astaxanthin Production by Haematococcuspluvialis Using Magnesium Aminoclay Nanoparticles. Bioresource Technology, 307, Arti-cle ID: 123270. [Google Scholar] [CrossRef] [PubMed]
[4] Ravi, S., Ambati, R.R., Kamath, S.B., et al. (2012) Influence of Different Culture Conditions on Yield of Biomass and Value Added Products in Microalgae. Dynamic Biochemistry, Process Biotechnology and Molecular Biology, 6, 77-85.
[5] Dan, Q., Wu, Y.C., Zhu, W.L., et al. (2012) Identification of Geometrical Isomers and Comparison of Different Isomeric Samples of Astaxanthin. Journal of Food Science, 77, C934-C940. [Google Scholar] [CrossRef] [PubMed]
[6] Donoso, A., González, J., Muñoz, A.A., González, P.A. and Agurto-Muñoz, C. (2021) Therapeutic Uses of Natural Astaxanthin: An Evidence-Based Review Focused on Human Clinical Trials. Pharmacological Research, 166, Article ID: 105479. [Google Scholar] [CrossRef] [PubMed]
[7] Brotosudarmo, T.H.P., Limantara, L. and Setiyono, E. (2020) Structures of Astaxanthin and Their Consequences for Therapeutic Application. International Journal of Food Science, 2020, Article ID: 2156582. [Google Scholar] [CrossRef] [PubMed]
[8] Nishida, Y., Nawaz, A., Hecht, K. and Tobe, K. (2022) Astaxanthin as a Novel Mitochondrial Regulator: A New Aspect of Carotenoids, beyond Antioxidants. Nutrients, 14, Article 107. [Google Scholar] [CrossRef] [PubMed]
[9] 张涛, 邓思, 陈艳红,等. 虾青素和β-胡萝卜素的抗氧化活性及其协同作用研究[J]. 食品与发酵工业, 2021, 47(9): 8-15.
[10] Grudzinski, W., Nierzwicki, L., Welc, R., et al. (2017) Lo-calization and Orientation of Xanthophylls in a Lipid Bilayer. Scientific Reports, 7, Article No. 9619. [Google Scholar] [CrossRef] [PubMed]
[11] Ekpe, L., Inaku, K. and Ekpe, V. (2018) Antioxidant Effects of Astaxanthin in Various Diseases—A Review. Journal of Molecular Pathophysiology, 7, 1-6. [Google Scholar] [CrossRef
[12] Augusti, P.R., Quatrin, A. Somacal, S., et al. (2012) Astaxan-thin Prevents Changes in the Activities of Thioredoxin Reductase and Paraoxonase in Hypercholesterolemic Rabbits. Journal of Clinical Biochemistry & Nutrition, 51, 42-49. [Google Scholar] [CrossRef] [PubMed]
[13] Han, J.H., Ju, J.H., Lee, Y.S., et al. (2018) Astaxanthin Alleviated Etha-nol-Induced Liver Injury by Inhibition of Oxidative Stress and Inflammatory Responses via Blocking of STAT3 Activity. Scientific Reports, 8, Article No. 14090. [Google Scholar] [CrossRef] [PubMed]
[14] Kim, J.H., Chang, M.J., Choi, H.D., et al. (2011) Protective Ef-fects of Haematococcus astaxanthin on Oxidative Stress in Healthy Smokers. Journal of Medicinal Food, 14, 1469-1475. [Google Scholar] [CrossRef] [PubMed]
[15] Yamashita, E. (2015) Let Astaxanthin Be thy Medicine. PharmaNutrition, 3, 115-122. [Google Scholar] [CrossRef
[16] Kohandel, Z., Farkhondeh, T., Aschner, M., et al. (2022) An-ti-Inflammatory Action of Astaxanthin and Its Use in the Treatment of Various Diseases. Biomedicine & Pharmacother-apy, 145, Article ID: 112179. [Google Scholar] [CrossRef] [PubMed]
[17] Hwang, Y.H., Hong, S.G., Mun, S.K., et al. (2019) The Protec-tive Effects of Astaxanthin on the OVA-Induced Asthma Mice Model. Molecules, 22, Article 2019. [Google Scholar] [CrossRef] [PubMed]
[18] Hongo, N. (2017) Daily Fatigue-Reducing Effect of Astaxan-thin―A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Study. 薬理と治療, 45, 61-72.
[19] Park, J.S., Chyun, J.H., Kim, Y.K., et al. (2010) Astaxanthin Decreased Oxidative Stress and Inflammation and Enhanced Immune Response in Humans. Nutrition & Metabolism, 7, Article No. 18. [Google Scholar] [CrossRef] [PubMed]
[20] Davinelli, S., Nielsen, M.E. and Scapagnini, G. (2018) Astaxanthin in Skin Health, Repair, and Disease: A Comprehensive Review. Nutrients, 10, Article 522. [Google Scholar] [CrossRef] [PubMed]
[21] Ng, Q.X., De Deyn, M.L.Z.Q., Loke, W., et al. (2021) Effects of Astaxanthin Supplementation on Skin Health: A Systematic Review of Clinical Studies. Journal of Dietary Supplements, 18, 169-182. [Google Scholar] [CrossRef] [PubMed]
[22] Samarghandian, S., Azimi-Nezhad, M. and Farkhondeh, T. (2019) Thymoquinone-Induced Antitumor and Apoptosis in Human Lung Adenocarcinoma Cells. Journal of Cellular Physiology, 234, 10421-10431. [Google Scholar] [CrossRef] [PubMed]
[23] Zhang, J., Ding, C., Zhang, S. and Xu, Y.Y. (2020) Neuroprotective Effects of Astaxanthin against Oxygen and Glucose Deprivation Damage via the PI3K/Akt/GSK3β/Nrf2 Signalling Pathway in Vitro. Journal of Cellular and Molecular Medicine, 24, 8977-8985. [Google Scholar] [CrossRef] [PubMed]
[24] Li, H., Li, J., Hou, C., et al. (2020) The Effect of Astaxanthin on Inflammation in Hyperosmolarity of Experimental Dry Eye Model in Vitro and in Vivo. Experimental Eye Research, 197, Article ID: 108113. [Google Scholar] [CrossRef] [PubMed]
[25] Shimokawa, T., Fukuta, T., Inagi, T. and Kogure, K. (2020) Pro-tective Effect of High-Affinity Liposomes Encapsulating Astaxanthin against Corneal Disorder in the in Vivo Rat Dry Eye Disease Model. Journal of Clinical Biochemistry and Nutrition, 66, 224-232. [Google Scholar] [CrossRef] [PubMed]
[26] Manabe, Y., Komatsu, T., Seki, S. and Sugawara, T. (2018) Dietary Astaxanthin Can Accumulate in the Brain of Rats. Bioscience, Biotechnology, and Biochemistry, 82, 1433-1436. [Google Scholar] [CrossRef] [PubMed]
[27] Nouchi, R., Suiko, T., Kimura, E., et al. (2020) Effects of Lutein and Astaxanthin Intake on the Improvement of Cognitive Functions among healthy Adults: A Systematic Review of Randomized Controlled Trials. Nutrients, 12, Article 617. [Google Scholar] [CrossRef] [PubMed]
[28] Yasui, Y., Hosokawa, M., Mikami, N., et al. (2011) Dietary Astaxanthin Inhibits Colitis and Colitis-Associated Colon Carcinogen-esis in Mice via Modulation of the Inflammatory Cytokines. Chemico-Biological Interactions, 193, 79-87. [Google Scholar] [CrossRef] [PubMed]
[29] Raza, S.H.A., Naqvi, S.R.Z., Abdelnour, S.A., et al. (2021) Benefi-cial Effects and Health Benefits of Astaxanthin Molecules on Animal Production: A Review. Research in Veterinary Science, 138, 69-78. [Google Scholar] [CrossRef] [PubMed]
[30] Palozza, P., Torelli, C., Boninsegna, A., Simone, R., Catalano, A., Mele, M.C. and Picci, N. (2009) Growth-Inhibitory Effects of the Astaxanthin-Rich Alga Haematococcus pluvialis in Human Coloncancer Cells. Cancer Letters, 283, 108-117. [Google Scholar] [CrossRef] [PubMed]
[31] Uchiyama, A. and Okada, Y. (2008) Clinical Efficacy of Astaxanthin-Containing Haematococcus pluvialis Extract for the Volunteers at Risk of Metabolic Syndrome. Journal of Clinical Biochemistry and Nutrition, 43, 390-393.
[32] Landon, R., Gueguen, V., Petite, H., et al. (2020) Impact of Astaxanthin on Diabetes Pathogenesis and Chronic Complications. Marine Drugs, 18, Article 357. [Google Scholar] [CrossRef] [PubMed]
[33] Maria, A.G., Graziano, R. and Nicolantonio, D.O. (2015) Carotenoids: Potential Allies of Cardiovascular Health? Food & Nutrition Research, 59, Article ID: 26762. [Google Scholar] [CrossRef] [PubMed]
[34] Monroy-Ruiz, J., Sevilla, M.Á., Carrón, R. and Monter, M.J. (2011) Astaxanthin-Enriched-Diet Reduces Blood Pressure and Improves Cardiovascular Parameters in Spontaneously Hyper-tensive Rats. Pharmacological Research, 63, 44-50. [Google Scholar] [CrossRef] [PubMed]
[35] Khan, S.K., Malinski, T., Mason, R.P., et al. (2010) Novel Astaxanthin Prodrug (CDX-085) Attenuates Thrombosis in a Mouse Model. Thrombosis Research, 126, 299-305. [Google Scholar] [CrossRef] [PubMed]
[36] EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck, D., Castenmiller, J., et al. (2020) Safety of Astaxanthin for Its Use as a Novel Food in Food Supplements. EFSA Journal, 18, e05993. [Google Scholar] [CrossRef] [PubMed]
[37] Martínez-Álvarez, Ó., Calvo, M.M. and Gómez-Estaca, J. (2020) Recent Advances in Astaxanthin Micro/Nanoencapsulation to Improve Its Stability and Functionality as a Food Ingredi-ent. Marine Drugs, 18, Article 406. [Google Scholar] [CrossRef] [PubMed]
[38] Villaró, S., Ciardi, M., Morillas-España, A., et al. (2021) Microalgae Derived Astaxanthin: Research and Consumer Trends and Industrial Use as Food. Foods, 10, Article 2303. [Google Scholar] [CrossRef] [PubMed]
[39] Zhao, T., Yan, X., Sun, L., et al. (2019) Research Progress on Extrac-tion, Biological Activities and Delivery Systems of Natural Astaxanthin. Trends in Food Science & Technology, 91, 354-361. [Google Scholar] [CrossRef
[40] Rao, A.R., Baskaran, V., Sarada, R. and Ravishankar, G.A. (2013) In Vivo Bioavailability and Antioxidant Activity of Carotenoids from Microalgal Biomass—A Repeated Dose Study. Food Research International, 54, 711-717. [Google Scholar] [CrossRef
[41] Rao, A.R., Sindhuja, H.N., Dharmesh, S.M., et al. (2013) Ef-fective Inhibition of Skin Cancer, Tyrosinase, and Antioxidative Properties by Astaxanthin and Astaxanthin Esters from the Green Alga Haematococcus pluvialis. Journal of Agricultural & Food Chemistry, 61, 3842-3851. [Google Scholar] [CrossRef] [PubMed]
[42] Satoh, T. (2016) Astaxanthin: Health Benefits and Toxicity. In: Gupta, R.C., Ed., Nutraceuticals, Academic Press, Cambridge, 531-539. [Google Scholar] [CrossRef
[43] Serebruany, V., Malinin, A., Goodin, T., et al. (2010) The in Vitro Effects of Xancor, a Synthetic Astaxanthine Derivative, on Hemostatic Biomarkers in Aspirin-Nave and As-pirin-Treated Subjects with Multiple Risk Factors for Vascular Disease. American Journal of Therapeutics, 17, 125-132. [Google Scholar] [CrossRef
[44] 李露壮, 姜衍, 徐爱华, 等. 虾青素对过氧化氢诱导的骨髓间充质干细胞氧化应激的保护作用[J]. 中国医科大学学报, 2021, 50(2): 124-129.
[45] 朱春晖, 张宜, 宋黄鹤, 等. 虾青素对叔丁基过氧化氢诱导软骨细胞损伤的保护作用[J]. 中国组织工程研究, 2022, 26(11): 1648-1655.
[46] 王僮. 虾青素及急性大强度运动对大鼠肝氧化应激影响的研究[D]: [硕士学位论文]. 太原: 山西大学, 2021.
[47] Shen, D.F., Qi, H.P., Ma, C., et al. (2021) Astaxanthin Suppresses Endoplasmic Reticulum Stress and Protects against Neuron Damage in Parkinson’s Disease by Regulating miR-7/SNCA Axis. Neuroscience Research, 165, 51-60. [Google Scholar] [CrossRef] [PubMed]
[48] 刘晓娟, 万慧琪, 许光辉, 等. 虾青素对非酒精性脂肪肝大鼠模型影响的实验研究[J]. 海峡药学, 2020, 32(11): 18-21.