三维生物打印在牙周组织工程的研究进展及展望

Progress and Prospect of 3D Bioprinting in Periodontal Reconstruction

摘要: 牙周炎是一种慢性炎症性疾病，导致牙周组织尤其是骨组织的破坏，是成年人失牙的首位原因。三维生物打印作为21世纪初的新兴技术，包裹细胞的生物墨水可通过模拟发育过程中组织的自组装促进再生，在组织工程中的应用前景巨大。3D打印技术带来了牙周再生方法的重大创新，三维打印不仅可以打印生物相容性膜和支架，还可以打印复杂3D功能组织中的活细胞和支持部件。本文综述了牙周再生领域相关的种子细胞、生长因子、生物支架，讨论了其目前面临的挑战，同时对其在牙周再生领域的应用进行了展望。

Abstract: Periodontitis is a chronic inflammatory disease that leads to the destruction of periodontal tissue, especially bone tissue, and is the first cause of tooth loss in adults. As an emerging technology in the early 21st century, three-dimensional (3D) bioprinting can promote regeneration by simulating the self-assembly of tissues during development, which has great application prospects in tissue engineering. 3D printing technology has led to major innovations in periodontal regeneration methods, allowing the printing not only of biocompatible membranes and scaffolds, but also of living cells and supporting components in complex 3D functional tissues. This paper reviews the research progress of the periodontal regeneration, which mainly refers to seed cells, growth factors and biological scaffold, and discusses their current challenges, applications in the field of periodontal regeneration.