不同治疗方案对宫颈HR-HPV感染的临床疗效分析

Analysis of the Clinical Efficacy of Different Treatment Regimens for Cervical HR-HPV Infection

摘要: 目的：本研究旨在分析重组人干扰素α-2b阴道泡腾片联合保妇康栓对HR-HPV感染患者的HPV、TCT的转归及阴道微生态的影响。方法：选取2021年1月~2022年12月于郑州大学第二附属医院妇科门诊就医的HR-HPV感染患者共200例，其宫颈病变程度均低于HSIL，依据治疗方案的不同分为双药组(干扰素联合保妇康栓双药治疗)、单药组(干扰素单药治疗)及观察组(未使用药物进行干预)，比较三组间HPV、TCT及阴道微生态的变化，以及不同年龄段HR-HPV的转阴率。结果：双药组HR-HPV的转阴率和总体有效率高于单药组及观察组(P < 0.017)；且双药组和单药组中<45岁患者的HR-HPV转阴率均高于≥45岁患者(P < 0.05)；双药组和单药组治疗后TCT正常率高于观察组(P < 0.017)；双药组和单药组患者阴道分泌物的PH值及Nugent评分均较治疗前好转(P < 0.05)，且双药组的好转情况更显著(P < 0.05)。结论：干扰素联合保妇康栓治疗可提高HR-HPV的转阴率及宫颈细胞学正常率，改善阴道微生态情况；且<45岁患者药物治疗效果更佳，预后更好。

Abstract: Objective: This study aimed to analyze the effects of recombinant human interferon α-2b vaginal effervescent tablets combined with Baofukang suppository on the regression of HPV, TCT and vaginal microecology in patients with HR-HPV infection. Methods: A total of 200 HR-HPV-infected patients with cervical lesions lower than HSIL who attended the gynecology outpatient clinic of the Second Affiliated Hospital of Zhengzhou University from January 2021 to December 2022 were selected and divided into the dual-drug group (interferon and povidone suppositories combined treatment), single-drug group (interferon monotherapy), and observation group (no drugs were used for the intervention) based on the difference in the treatment regimen, and the changes in HPV, TCT, and vaginal microecology, as well as the rate of conversion of HR-HPV in different age groups, were compared among the three groups. Results: The negative conversion rate and overall effective rate of HR-HPV in the dual-drug group were higher than those in the single-drug group and the observation group (P < 0.017); the negative conversion rate of HR-HPV in patients younger than 45 years old was higher than that in patients over 45 years old in both the dual-drug and single-drug groups (P < 0.05); the normalization rate of post-treatment TCT was higher than that of the observation group in both the dual-drug and single-drug groups (P < 0.017); the pH value and Nugent score of vaginal secretions of patients in both the dual-drug group and the single-drug group were better than before treatment (P < 0.05), and the improvement was more significant in the dual-drug group (P < 0.05). Conclusion: Interferon combined with Baofukang suppository treatment can improve the conversion rate of HR-HPV and the normal rate of cervical cytology, and improve the vaginal microecological situation; and patients younger than 45 years old have a better drug treatment effect and a better prognosis.