基于相位分辨算法的OCT弹性测量方法的研究

Study of OCT Elasticity Measurement Method based on Phase-Resolved Algorithm

摘要: 生物组织力学特性的变化对于医学研究具有重要的研究意义。为了实现对弹性信息的提取和量化，本文基于剪切波量化杨氏模量的相关理论和扫频光学相干层析成像技术提出了一种弹性测量方法，在此基础上设计并搭建了一套基于扫频OCT的光学相干弹性成像系统。系统使用压电堆栈输出双脉冲激励产生剪切波，通过相位分辨算法实现了对样品内部速度信息的提取和测量，并在此基础上实现对样品剪切波的测量和弹性模量的量化。通过对琼脂样品施加双脉冲激励进行剪切波量化杨氏模量的实验测试，测得的琼脂样品平均杨氏模量为23.29 kPa，与理论结果基本一致，从而验证了基于本系统的弹性测量方法的可行性。

Abstract: The investigation of changes in the mechanical properties of biological tissues holds paramount significance in medical research. This paper presents an elasticity measurement method aimed at extracting and quantifying elasticity information. The proposed method integrates theories related to the quantification of Young’s modulus using shear waves and utilizes swept optical coherence tomography (OCT) techniques. A novel optical coherence elasticity imaging system based on swept OCT is designed and constructed as a platform for this method. The system employs piezoelectric stack-generated double-pulse excitation to induce shear waves and utilizes a phase-resolu- tion algorithm for the extraction and measurement of the internal velocity of the sample. Furthermore, the system facilitates the quantification of sample elasticity through shear wave measurement. Experimental validation of the proposed method is conducted on agar samples utilizing double-pulse excitation to quantify the Young’s modulus of shear waves. The measured average Young’s modulus of the agar samples is found to be 23.29 kPa, demonstrating close alignment with theoretical expectations and thereby affirming the feasibility of the proposed elasticity measurement method facilitated by this system.