西酞普兰中毒致5-羟色胺综合征1例
A Case of 5-Hydroxytryptamine Syndrome Caused by Citalopram Poisoning
DOI: 10.12677/jcpm.2024.32077, PDF,    科研立项经费支持
作者: 崔园园*：济宁医学院临床医学院，山东 济宁；刘 雷, 李 含：济宁医学院附属医院全科医学科，山东 济宁；李 静：济宁医学院附属医院急诊科，山东 济宁
关键词: 西酞普兰；5-羟色胺综合征；药物中毒；Citalopram； 5-Hydroxytryptamine Syndrome； Drug Poisoning
摘要: 西酞普兰作为一种高选择性5-羟色胺再摄取抑制剂，临床广泛用于治疗抑郁症。5-羟色胺综合征是5-羟色胺大量蓄积导致中枢5-羟色胺能系统过度兴奋而出现的恶性综合征。西酞普兰过量致5-羟色胺综合征有潜在的致死风险，目前有关西酞普兰过量的临床数据有限，总体救治经验少，本文对1例因西酞普兰中毒致5-羟色胺综合征患者成功的诊治过程进行了回顾和分析，并参考了国内外相关文献，以期为今后的临床工作提供参考及借鉴。
Abstract: Citalopram, as a highly selective serotonin reuptake inhibitor, is widely used in the treatment of depression. 5-hydroxytryptamine syndrome is a malignant syndrome in which the central serotonin system is overexcited due to the accumulation of serotonin. There is a potential risk of death in serotonin syndrome caused by citalopram overdose. Currently, there are limited clinical data on citalopram overdose, and the overall treatment experience is limited. In this paper, the successful diagnosis and treatment process of a patient with serotonin syndrome caused by citalopram poisoning was reviewed and analyzed, and relevant literature at home and abroad was referred in order to provide reference for future clinical work.
文章引用：崔园园, 刘雷, 李含, 李静. 西酞普兰中毒致5-羟色胺综合征1例[J]. 临床个性化医学, 2024, 3(2): 525-529. https://doi.org/10.12677/jcpm.2024.32077

参考文献

[1] 林心, 林玲, 林雁娟. 福州市某三甲医院院前急救患者流行病学分析[J]. 中华灾害救援医学, 2019, 7(5): 241-244.
[2] 宋维, 姚津剑, 朱江, 欧阳艳红, 曾琦, 吴国平, 孟庆华, 王日兴, 张汉洪, 王微, 刘裕芬, 孙定卫, 胡碧江, 严首春. 海南急性中毒诊断与治疗共识[J]. 海南医学, 2011, 22(10): 134-140.
[3] 汪友平, 张翠玲, 赖荣德, 等. 精神药物中毒287例回顾性分析[J]. 岭南急诊医学杂志, 2023, 28(2): 108-111.
[4] Wang, R.Z., Vashistha, V., Kaur, S. and Houchens, N.W. (2016) Serotonin Syndrome: Preventing, Recognizing, and Treating It. Cleveland Clinic Journal of Medicine, 83, 810-816. [Google Scholar] [CrossRef] [PubMed]
[5] 宋燕, 孙洁, 曹红云, 等. 利奈唑胺与5-羟色胺能药物合用致5-羟色胺综合征1例[J]. 中国医院药学杂志, 2020, 40(5): 590-591. [Google Scholar] [CrossRef] 
[6] 马旭, 张艳华. 临床药师参与1例芬太尼相关5-羟色胺综合征的治疗实践及文献复习[J]. 中国临床药学杂志, 2021, 30(4): 297-301. [Google Scholar] [CrossRef] 
[7] Glassman, A.H. (1997) Citalopram Toxicity. The Lancet, 350, 818. [Google Scholar] [CrossRef] [PubMed]
[8] Kraai, E.P. and Seifert, S.A. (2014) Citalopram Overdose: A Fatal Case. Journal of Medical Toxicology, 11, 232-236. [Google Scholar] [CrossRef] [PubMed]
[9] Dunkley, E.J.C., Isbister, G.K., Sibbritt, D., Dawson, A.H. and Whyte, I.M. (2003) The Hunter Serotonin Toxicity Criteria: Simple and Accurate Diagnostic Decision Rules for Serotonin Toxicity. QJM, 96, 635-642. [Google Scholar] [CrossRef] [PubMed]
[10] 武冬冬, 李淑华, 苏闻, 等. 抗帕金森病药物诱发5-羟色胺综合征1例[J]. 诊断学理论与实践, 2023, 22(3): 303-305. [Google Scholar] [CrossRef] 
[11] 黎敏, 李超乾, 卢中秋, 等. 急性中毒的诊断与治疗专家共识[J]. 中华卫生应急电子杂志, 2016, 2(6): 333-347.
[12] 唐红波. 108例急诊药物中毒患者临床特征及治疗分析[J]. 中文科技期刊数据库(全文版)医药卫生, 2021(8): 54-55.
[13] 黎敏, 李超乾, 卢中秋, 宋维, 田英平, 杨立山, 张劲松, 张新超, 赵敏, 赵晓东, 禇沛, 周荣斌. 急性中毒的诊断与治疗专家共识[J]. 中华卫生应急电子杂志, 2016, 2(6): 333-347.
[14] Ferrari, F., Manera, M., D’Auria, L., De Rosa, S. and Ronco, C. (2023) Hemoperfusion in Poisoning and Drug Overdose. Contributions to Nephrology, 200, 218-241.
[15] Ke, J., Wei, Y. and Chen, B. (2023) Application of Hemoperfusion in the Treatment of Acute Poisoning. Blood Purification, 53, 49-60. [Google Scholar] [CrossRef] [PubMed]