自发性腹膜炎相关检测技术的研究进展
Advances in Detection Techniques Related to Spontaneous Peritonitis
DOI: 10.12677/acm.2024.1461913, PDF,   
作者: 肖斌青, 黄大元：吉首大学医学院，湖南 吉首；李勇忠：湖南医药学院总医院感染病中心，湖南 怀化
关键词: 自发性腹膜炎；检测技术；疾病管理；Spontaneous Peritonitis； Detection Techniques； Disease Management
摘要: 自发性腹膜炎(spontaneous bacterialperitonitis, SBP)作为肝硬化腹水患者常见的严重并发症。延迟诊断、错误诊断和未能及时采用有效的抗生素，可严重影响患者的预后。SBP的诊断主要依赖于有创性检测方式，其存在感染、低效能等局限性，相对无创及更高检测效能的生物标志物和技术逐渐发展为该领域的热点。合理使用相关检测技术对实现该病的综合管理具有重要的临床意义。本文基于SBP相关检测技术进行阐述，旨在为临床诊治SBP提供一些依据。
Abstract: Spontaneous bacterial peritonitis (SBP) is a common and serious complication in patients with cirrhotic ascites. Delayed diagnosis, misdiagnosis and failure to use effective antibiotics in time can seriously affect the prognosis of patients. The diagnosis of SBP mainly relies on invasive testing, which has limitations such as infection and inefficiency, and relatively non-invasive biomarkers and techniques with higher detection efficacy are gradually developing as hotspots in this field. The rational use of relevant detection technologies is of great clinical significance in achieving comprehensive management of the disease. This article is based on SBP related detection techniques and aims to provide some basis for clinical diagnosis and treatment of SBP.
文章引用：肖斌青, 李勇忠, 黄大元. 自发性腹膜炎相关检测技术的研究进展[J]. 临床医学进展, 2024, 14(6): 1302-1309. https://doi.org/10.12677/acm.2024.1461913

参考文献

[1] Haque, L.Y. and Garcia‐Tsao, G. (2021) A Historical Overview of Spontaneous Bacterial Peritonitis: From Rare to Resistant. Clinical Liver Disease, 18, 63-75. [Google Scholar] [CrossRef] [PubMed]
[2] 徐小元, 丁惠国, 李文刚, 等.肝硬化腹水及相关并发症的诊疗指南(2017, 北京) [J]. 中华胃肠内镜电子杂志, 2018, 5(1): 1-17.
[3] King, J.J., Halliday, N., Mantovani, A., Gerussi, A., Wey, E.Q., Tan, J., et al. (2023) Bacterascites Confers Poor Patient Prognosis Beyond MELD Prediction. Liver Transplantation, 29, 356-364. [Google Scholar] [CrossRef] [PubMed]
[4] Biggins, S.W., Angeli, P., Garcia‐Tsao, G., Ginès, P., Ling, S.C., Nadim, M.K., et al. (2021) Diagnosis, Evaluation, and Management of Ascites, Spontaneous Bacterial Peritonitis and Hepatorenal Syndrome: 2021 Practice Guidance by the American Association for the Study of Liver Diseases. Hepatology, 74, 1014-1048. [Google Scholar] [CrossRef] [PubMed]
[5] Kim, J.J., Tsukamoto, M.M., Mathur, A.K., Ghomri, Y.M., Hou, L.A., Sheibani, S., et al. (2014) Delayed Paracentesis Is Associated with Increased In-Hospital Mortality in Patients with Spontaneous Bacterial Peritonitis. American Journal of Gastroenterology, 109, 1436-1442. [Google Scholar] [CrossRef] [PubMed]
[6] Khan, S. and Linganna, M. (2023) Diagnosis and Management of Ascites, Spontaneous Bacterial Peritonitis, and Hepatorenal Syndrome. Cleveland Clinic Journal of Medicine, 90, 209-213. [Google Scholar] [CrossRef] [PubMed]
[7] Smith-Hanratty, B. (2023) Performing Abdominal Paracentesis. The Journal for Nurse Practitioners, 19, Article ID: 104534. [Google Scholar] [CrossRef] 
[8] 王燕, 陈萍, 段晓菲, 等. 某传染病医院患者医院感染危险因素及其风险级别分析[J]. 预防医学情报杂志, 2020, 36(1): 58-61.
[9] Aithal, G.P., Palaniyappan, N., China, L., Härmälä, S., Macken, L., Ryan, J.M., et al. (2020) Guidelines on the Management of Ascites in Cirrhosis. Gut, 70, 9-29. [Google Scholar] [CrossRef] [PubMed]
[10] Bruno, R., Caraceni, C., D’Amico, P., Grattagliano, G., La Mura, I., Riggio, V., Schepis, O., Senzolo, F., Angeli, M. and Paolode Franchis, R. (2021) Portal Hypertension and Ascites: Patient-and Population-Centered Clinical Practice Guidelines by the Italian Association for the Study of the Liver (AISF). Digestive and Liver Disease, 53, 1089-1104.
[11] 徐小元, 丁惠国, 贾继东,等. 肝硬化腹水诊疗指南(2023年版) [J]. 中华肝脏病杂志, 2023, 31(8): 813-824.
[12] Kalafati, L., Hatzioannou, A., Hajishengallis, G. and Chavakis, T. (2022) The Role of Neutrophils in Trained Immunity. Immunological Reviews, 314, 142-157. [Google Scholar] [CrossRef] [PubMed]
[13] 高方博, 白朝辉, 林苏,等. 《2020年英国胃肠病学会与英国肝病学会指南: 肝硬化腹水管理》摘译[J]. 临床肝胆病杂志, 2021, 37(2): 302-303.
[14] 韩晶, 刘强, 周晓琳. 肝硬化原发性腹膜炎早期诊断的研究进展[J]. 中国当代医药, 2023, 30(8): 54-58.
[15] Popoiag, R., Suceveanu, A., Suceveanu, A., Micu, S., Voinea, F., Mazilu, L., et al. (2021) Predictors of Spontaneous Bacterial Peritonitis in Romanian Adults with Liver Cirrhosis: Focus on the Neutrophil-to-lymphocyte Ratio. Experimental and Therapeutic Medicine, 22, Article No. 983. [Google Scholar] [CrossRef] [PubMed]
[16] 徐小元, 丁惠国, 李文刚, 等. 肝硬化腹水及相关并发症的诊疗指南[J]. 实用肝脏病杂志, 2018, 21(1): 21-31.
[17] 郑俊福, 李磊. 放宽肝硬化腹水中性多核粒细胞的诊断标准对自发性细菌性腹膜炎的早期诊断价值[J]. 胃肠病学和肝病学杂志, 2019, 28(7): 740-743.
[18] Xiao, Z., Shen, D., Lan, T., Wei, C., Wu, W., Sun, Q., et al. (2022) Reduction of Lactoferrin Aggravates Neuronal Ferroptosis after Intracerebral Hemorrhagic Stroke in Hyperglycemic Mice. Redox Biology, 50, Article ID: 102256. [Google Scholar] [CrossRef] [PubMed]
[19] Sabra, S. and Agwa, M.M. (2020) Lactoferrin, a Unique Molecule with Diverse Therapeutical and Nanotechnological Applications. International Journal of Biological Macromolecules, 164, 1046-1060. [Google Scholar] [CrossRef] [PubMed]
[20] Kowalczyk, P., Kaczyńska, K., Kleczkowska, P., Bukowska-Ośko, I., Kramkowski, K. and Sulejczak, D. (2022) The Lactoferrin Phenomenon—A Miracle Molecule. Molecules, 27, Article 2941. [Google Scholar] [CrossRef] [PubMed]
[21] El-Nokeety, M., Abuelfadl, S., Heikl, A. and Rashed, L. (2018) Does Ascitic Fluid Lactoferrin Has a Role in the Diagnosis and Follow up of Spontaneous Bacterial Peritonitis in Hepatitis C Virus Cirrhotic Patients. Kasr Al Ainy Medical Journal, 24, 53. [Google Scholar] [CrossRef] 
[22] Lee, S.S., Min, H.J., Choi, J.Y., Cho, H.C., Kim, J.J., Lee, J.M., et al. (2016) Usefulness of Ascitic Fluid Lactoferrin Levels in Patients with Liver Cirrhosis. BMC Gastroenterology, 16, Article No 132. [Google Scholar] [CrossRef] [PubMed]
[23] Sprenkeler, E.G.G., Zandstra, J., van Kleef, N.D., Goetschalckx, I., Verstegen, B., Aarts, C.E.M., et al. (2022) S100A8/A9 Is a Marker for the Release of Neutrophil Extracellular Traps and Induces Neutrophil Activation. Cells, 11, Article 236. [Google Scholar] [CrossRef] [PubMed]
[24] Fortuny, M., Sarrias, M., Torner, M., Iborra, I., Clos, A., Ardèvol, A., et al. (2023) Systematic Review of the Role of Calprotectin in Cirrhosis. European Journal of Clinical Investigation, 54, e14111. [Google Scholar] [CrossRef] [PubMed]
[25] Abdel-Razik, A., Abdelsalam, M., Gad, D.F., Abdelwahab, A., Tawfik, M., Elzehery, R., et al. (2020) Recurrence of Spontaneous Bacterial Peritonitis in Cirrhosis: Novel Predictors. European Journal of Gastroenterology & Hepatology, 32, 718-726. [Google Scholar] [CrossRef] [PubMed]
[26] Fernandes, S.R., Santos, P., Fatela, N., Baldaia, C., Tato Marinho, R., Proença, H., et al. (2016) Ascitic Calprotectin Is a Novel and Accurate Marker for Spontaneous Bacterial Peritonitis. Journal of Clinical Laboratory Analysis, 30, 1139-1145. [Google Scholar] [CrossRef] [PubMed]
[27] Patel, K.P., Korbitz, P.M., Gallagher, J.P., Schmidt, C., Ingviya, T. and Manatsathit, W. (2022) Ascitic Calprotectin and Lactoferrin for Detection of Spontaneous Bacterial Peritonitis: A Systematic Review and Meta-Analysis. Translational Gastroenterology and Hepatology, 7, 37-37. [Google Scholar] [CrossRef] [PubMed]
[28] Fisher, J. and Linder, A. (2017) Heparin‐Binding Protein: A Key Player in the Pathophysiology of Organ Dysfunction in Sepsis. Journal of Internal Medicine, 281, 562-574. [Google Scholar] [CrossRef] [PubMed]
[29] Kong, Y., Ye, Y., Ma, J. and Shi, G. (2022) Accuracy of Heparin-Binding Protein for the Diagnosis of Nosocomial Meningitis and Ventriculitis. Critical Care, 26, Article No. 56. [Google Scholar] [CrossRef] [PubMed]
[30] Wu, Y., Yo, C., Hsu, W., Qian, F., Wu, B., Dou, Q., et al. (2020) Accuracy of Heparin-Binding Protein in Diagnosing Sepsis: A Systematic Review and Meta-Analysis. Critical Care Medicine, 49, e80-e90. [Google Scholar] [CrossRef] [PubMed]
[31] Mikuła, T., Sapuła, M., Jabłońska, J., Kozłowska, J., Stańczak, W., Krankowska, D., et al. (2018) Significance of Heparin-Binding Protein and D-Dimers in the Early Diagnosis of Spontaneous Bacterial Peritonitis. Mediators of Inflammation, 2018, Article ID: 1969108. [Google Scholar] [CrossRef] [PubMed]
[32] 张晨. 肝硬化腹水伴自发性细菌性腹膜炎患者腹水HBP、CRP水平及其对预后的影响[J]. 河南医学研究, 2021, 30(18): 3329-3332.
[33] 韩丽娜, 荣义辉. 感染性疾病应用中性粒细胞CD64的研究进展[J]. 中国继续医学教育, 2021, 13(14): 195-198.
[34] van de Ven, N.L.M., Bongers, S.H., Spijkerman, R., Koenderman, L., Leenen, L.P.H., Hietbrink, F., et al. (2023) Point-of-Care Neutrophil CD64 as a Rule in Diagnostic Test for Bacterial Infections in the Emergency Department. BMC Emergency Medicine, 23, Article No. 28. [Google Scholar] [CrossRef] [PubMed]
[35] Gao, Y., Lin, L., Zhao, J., Peng, X. and Li, L. (2022) Neutrophil CD64 Index as a Superior Indicator for Diagnosing, Monitoring Bacterial Infection, and Evaluating Antibiotic Therapy: A Case Control Study. BMC Infectious Diseases, 22, Article No. 892. [Google Scholar] [CrossRef] [PubMed]
[36] Liu, Q., Gao, Y., Yang, T., Zhou, Z., Lin, K., Zhang, W., et al. (2022) Ncd64 Index as a Novel Inflammatory Indicator for the Early Prediction of Prognosis in Infectious and Non-Infectious Inflammatory Diseases: An Observational Study of Febrile Patients. Frontiers in Immunology, 13, Article 905060. [Google Scholar] [CrossRef] [PubMed]
[37] Nabiel, Y., Barakat, G. and Abed, S. (2019) Serum CD64 and Ascitic Fluid Calprotectin and Microrna-155 as Potential Biomarkers of Spontaneous Bacterial Peritonitis. European Journal of Gastroenterology & Hepatology, 31, 1064-1069. [Google Scholar] [CrossRef] [PubMed]
[38] 齐林, 王亚丽, 付建珠,等. 中性粒细胞CD64表达的影响因素研究进展[J]. 临床与病理杂志, 2021, 41(9): 2180-2186.
[39] Dang, Y., Lou, J., Yan, Y., Yu, Y., Chen, M., Sun, G., et al. (2016) The Role of the Neutrophil Fcγ Receptor I (CD64) Index in Diagnosing Spontaneous Bacterial Peritonitis in Cirrhotic Patients. International Journal of Infectious Diseases, 49, 154-160. [Google Scholar] [CrossRef] [PubMed]
[40] 李虤, 易清平, 潘金平,等. 外周血PCT、SAA、白细胞计数、CRP、CD64及腹水CD64联合检测对肝硬化并SBP的临床疗效研究[J]. 黑龙江医药科学, 2022, 45(6): 32-33.
[41] 李晓丹, 徐立勇, 杜识博, 等. CD32、CD64和PCT在肝硬化合并自发性细菌性腹膜炎患者腹水中的水平及诊断意义[J]. 河北医药, 2019, 41(15): 2304-2306, 2310.
[42] 高小梅, 冷雪芹. 自发性细菌性腹膜炎的血清学标志物研究进展[J]. 中国医学创新, 2022, 19(28): 173-176.
[43] Seyedi, S.A., Nabipoorashrafi, S.A., Hernandez, J., Nguyen, A., Lucke-Wold, B., Nourigheimasi, S., et al. (2022) Neutrophil to Lymphocyte Ratio and Spontaneous Bacterial Peritonitis among Cirrhotic Patients: A Systematic Review and Meta-Analysis. Canadian Journal of Gastroenterology and Hepatology, 2022, Article ID: 8604060. [Google Scholar] [CrossRef] [PubMed]
[44] Ashish Baweja,, Rajat Jhamb,, Roshan Kumar,, Seema Garg, and Priyanka Gogoi, (2021) Clinical Utility of Neutrophil Lymphocyte Ratio (NLR) as a Marker of Spontaneous Bacterial Peritonitis (SBP) in Patients with Cirrhosis—An Exploratory Study. International Journal of Science and Research Archive, 3, 31-42. [Google Scholar] [CrossRef] 
[45] Awad, S.A., Ahmed, E.S. and Mohamed, E.E. (2020) Role of Combined Blood Neutrophil-Lymphocyte Ratio and C-Reactive Protein in Diagnosis of Spontaneous Bacterial Peritonitis. Benha Journal of Applied Sciences, 5, 1-7. [Google Scholar] [CrossRef] 
[46] Ngo, H. and Gantioque, R. (2017) Predictors of Spontaneous Bacterial Peritonitis (SBP) in Liver Cirrhosis: Current Knowledge and Future Frontiers. Open Journal of Gastroenterology, 7, 297-307. [Google Scholar] [CrossRef] 
[47] 祁艳东. 规范微生物标本采集流程在微生物检验中的应用效果分析[J]. 中文科技期刊数据库(文摘版)医药卫生, 2023(1): 1-3.
[48] Arzivian, A. and Duong, T. (2023) The Incidence of Spontaneous Bacterial Peritonitis in Patients with Cirrhosis-Related Ascites Undergoing Elective Outpatient Large-Volume Paracentesis. Cureus, 15, e50191. [Google Scholar] [CrossRef] [PubMed]
[49] Runyon, B.A., Canawati, H.N. and Akriviadis, E.A. (1988) Optimization of Ascitic Fluid Culture Technique. Gastroenterology, 95, 1351-1355. [Google Scholar] [CrossRef] [PubMed]
[50] 郭彦彤, 刘仲明, 张海燕, 等. 分子即时检测(POCT)技术及其在新发传染病中的应用[J]. 中国生物工程杂志, 2022, 42(9): 50-57.
[51] Deurenberg, R.H., Bathoorn, E., Chlebowicz, M.A., Couto, N., Ferdous, M., García-Cobos, S., et al. (2017) Application of Next Generation Sequencing in Clinical Microbiology and Infection Prevention. Journal of Biotechnology, 243, 16-24. [Google Scholar] [CrossRef] [PubMed]
[52] 卢美伊, 朱志军, 胡开明, 等. 高通量测序技术在病原体检测中的临床应用进展[J]. 中国感染与化疗杂志, 2023, 23(1): 107-110.
[53] Wu, H., Wei, F., Zhang, W., Han, J., Guo, S., Wang, Z., et al. (2023) Clinical Evaluation of Metagenomic Next-Generation Sequencing Method for the Diagnosis of Suspected Ascitic Infection in Patients with Liver Cirrhosis in a Clinical Laboratory. Microbiology Spectrum, 11, e0294622. [Google Scholar] [CrossRef] [PubMed]
[54] 马潇枭, 牟干, 刘玲, 等. 感染性病原体二代测序技术研究进展[J]. 中华医院感染学杂志, 2021, 31(11): 1754-1760.
[55] Natoli, R.M., Marinos, D.P., Montalvo, R.N., Degani, Y., Ochenjele, G., Griffith, C., et al. (2022) Poor Agreement between Next-Generation DNA Sequencing and Bacterial Cultures in Orthopaedic Trauma Procedures. Journal of Bone and Joint Surgery, 104, 497-503. [Google Scholar] [CrossRef] [PubMed]
[56] 沈婉林. 病原宏基因组学二代测序技术在肺部感染性疾病鉴别诊断中的临床应用研究[D]: [硕士学位论文]. 大连: 大连医科大学, 2021.
[57] Xia, Z.F. and Wu, G.S. (2019) [Role of Cytokines in Sepsis and Its Current Situation of Clinical Application]. Chinese Journal of Burns, 35, 3-7.
[58] Qian, D. and Zhang, Y. (2021) Influence of Xuebijing Injection Combined with Cefoperazone Sodium and Sulbactam Sodium in Treating Hepatitis B-Induced Liver Cirrhosis Complicated by Spontaneous Bacterial Peritonitis: TNF-α, IL-18, IL-6, and Hepatic Function. American Journal of Translational Research, 13, 2907-2914.
[59] Zhai, W., Wang, Z., Ye, C., Ke, L., Wang, H. and Liu, H. (2023) IL-6 Mutation Attenuates Liver Injury Caused by Aeromonas Hydrophila Infection by Reducing Oxidative Stress in Zebrafish. International Journal of Molecular Sciences, 24, Article 17215. [Google Scholar] [CrossRef] [PubMed]
[60] Verma, R., Satapathy, S.K. and Bilal, M. (2022) Procalcitonin and C-Reactive Protein in the Diagnosis of Spontaneous Bacterial Peritonitis. Translational Gastroenterology and Hepatology, 7, 36-36. [Google Scholar] [CrossRef] [PubMed]
[61] Del Giudice, M. and Gangestad, S.W. (2018) Rethinking IL-6 and CRP: Why They Are More than Inflammatory Biomarkers, and Why It Matters. Brain, Behavior, and Immunity, 70, 61-75. [Google Scholar] [CrossRef] [PubMed]

为你推荐