铁死亡与线粒体自噬在心肌纤维化中的研究进展
Research Progress on Ferroptosis and Mitophagy in Myocardial Fibrosis
DOI: 10.12677/acm.2024.1461926, PDF,   
作者: 刘一丹, 杨百元*:成都市第七人民医院(成都医学院附属肿瘤医院)神经内科,四川 成都
关键词: 铁死亡线粒体自噬心肌纤维化Ferroptosis Mitophagy Myocardial Fibrosis
摘要: 心肌纤维化是心脏结构重构的主要原因,可引起心力衰竭、心律失常。铁死亡及线粒体自噬自提出以来已被发现参与多种疾病的发生发展过程,二者在氧化还原稳态、铁稳态等方面存在机制交叉点。初步证据提示线粒体自噬是铁死亡的上游调节点,也有研究表明铁死亡及线粒体自噬均在心肌纤维化中存在重要作用。本文对铁死亡与线粒体自噬在心肌纤维化中的研究进展作一综述。
Abstract: Myocardial fibrosis is a primary cause of cardiac structural remodeling, leading to heart failure and arrhythmia. Since the proposal of ferroptosis and mitophagy, both have been found to participate in the development of various diseases, with intersecting mechanisms in areas such as redox homeostasis and iron homeostasis. Preliminary evidence suggests that mitophagy is an upstream regulatory node of ferroptosis. Research indicates that both ferroptosis and mitophagy play significant roles in myocardial fibrosis. Herein, we review the research progress on the roles of ferroptosis and mitophagy in myocardial fibrosis.
文章引用:刘一丹, 杨百元. 铁死亡与线粒体自噬在心肌纤维化中的研究进展[J]. 临床医学进展, 2024, 14(6): 1388-1396. https://doi.org/10.12677/acm.2024.1461926

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