Toll样受体在脑卒中疾病中的研究进展
Research Progress of Toll-Like Receptors in Stroke Disease
DOI: 10.12677/acm.2024.1472011, PDF,   
作者: 张宏阁, 梁欣怡, 李 豆, 杨梓钰, 姚佳乐：延安大学咸阳医院神经内科，陕西 咸阳；延安大学医学院，陕西 延安；张 维*：延安大学咸阳医院神经内科，陕西 咸阳；眉山心脑血管病医院神经内科，四川 眉山
关键词: 脑卒中；Toll样受体；病理机制；综述；Stroke； Toll-Like Receptors； Pathomechanism； Review
摘要: 脑卒中是危害人类健康的首要杀手，它具有高发病率、高死亡率、高致残率、高复发率、高经济负担5大特点，为患者及家庭带来严重负担。脑缺血后的炎症反应是加重神经功能损伤的病理机制之一。Toll样受体在炎症反应中发挥重要作用，近年来已成为人们关注和研究的焦点之一。文章就Toll样受体在脑卒中导致的缺血损伤过程中的炎症反应研究做一综述，旨在为Toll受体在脑缺血损伤病理机制中作用的进一步研究和治疗药物靶点的确定提供参考。
Abstract: Stroke is the main killer of human health. It has five characteristics: high morbidity, high mortality, high disability rate, high recurrence rate and high economic burden, which brings serious burden to patients and families. The inflammatory response after cerebral ischemia is one of the pathological mechanisms that aggravate nerve function injury. Toll-like receptors play an important role in inflammatory response and have become one of the focuses of attention and research in recent years. This article reviews the study on the inflammatory response of Toll-like receptors in ischemic injury caused by stroke, aiming to provide reference for further study on the role of Toll-like receptors in the pathological mechanism of ischemic injury and identification of therapeutic drug targets.
文章引用：张宏阁, 张维, 梁欣怡, 李豆, 杨梓钰, 姚佳乐. Toll样受体在脑卒中疾病中的研究进展[J]. 临床医学进展, 2024, 14(7): 279-285. https://doi.org/10.12677/acm.2024.1472011

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