基于足细胞损伤探讨黄芪治疗糖尿病肾病的作用机制
Study on the Mechanism of Radix Astragali in the Treatment of Diabetic Nephropathy Based on Podocyte Injury
DOI: 10.12677/tcm.2024.137223, PDF,   
作者: 邢 影：成都中医药大学临床医学院，四川 成都；陈 彤*：成都中医药大学附属医院肾病二科，四川 成都
关键词: 糖尿病肾病；足细胞；黄芪甲苷；黄芪多糖；Diabetic Nephropathy； Podocyte； Astragaloside IV； Astragalus Polysaccharide
摘要: 糖尿病肾病(Diabetic Nephropathy, DN)是由糖尿病所引起的微血管并发症之一，其临床表现主要为蛋白尿及进行性肾功能下降。足细胞是构成肾小球滤过屏障的关键部分，其形态或功能的变化在蛋白尿的形成和进展中扮演着至关重要的角色。近年来，研究发现黄芪可通过多种途径对肾脏发挥保护作用。本文将从改善糖脂代谢及胰岛素抵抗、减轻氧化应激反应、减轻炎症反应、抑制足细胞上皮间充质转化、抑制内质网应激、干预自噬、改善足细胞黏附功能障碍等方面探讨黄芪修复足细胞损伤、延缓糖尿病肾病的主要机制。
Abstract: Diabetic Nephropathy (DN) is one of the microvascular complications caused by diabetes. Its clinical manifestations are mainly albuminuria and progressive renal function decline. Podocytes are the key parts of glomerular filtration barrier, and their morphological or functional changes play an important role in the formation and progression of proteinuria. In recent years, studies have found that Radix Astragali can protect the kidney in a variety of ways. This article will explore the main mechanism of repairing podocyte injury and delaying diabetic nephropathy by Astragalus membranaceus from the aspects of improving glucose and lipid metabolism and insulin resistance, reducing oxidative stress, reducing inflammation, inhibiting podocyte epithelial-mesenchymal transformation, inhibiting endoplasmic reticulum stress, interfering with autophagy and improving podocyte adhesion dysfunction.
文章引用：邢影, 陈彤. 基于足细胞损伤探讨黄芪治疗糖尿病肾病的作用机制[J]. 中医学, 2024, 13(7): 1465-1471. https://doi.org/10.12677/tcm.2024.137223

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