糖尿病肾病贫血治疗进展
Advances in the Treatment of Anemia in Diabetic Kidney Disease
DOI: 10.12677/acm.2024.1482259, PDF,   
作者: 韩雅娇：延安大学附属医院肾内科，陕西 延安
关键词: 糖尿病肾病；贫血；治疗；Diabetic Kidney Disease； Anemia； Treatment
摘要: 贫血是慢性肾脏病(CKD)的主要并发症，也是心血管事件和生活质量低下(QoL)的风险因素。而糖尿病肾病(DKD)是导致CKD的主要原因，且DKD相关性贫血发生更早、更严重，其机制更为复杂。本文就慢性肾脏病贫血管理指南及相关研究，综述糖尿病肾病贫血的发生机制及治疗进展。
Abstract: Anemia is a major complication of chronic kidney disease (CKD) and a risk factor for cardiovascular events and poor quality of life (QoL). In contrast, diabetic kidney disease (DKD) is the main cause of CKD, and DKD-associated anemia occurs earlier, is more severe, and its mechanisms are more complex. In this article, we review the mechanism of anemia in diabetic kidney disease and the progress of treatment with regard to the guidelines for anemia management in chronic kidney disease and related studies.
文章引用：韩雅娇. 糖尿病肾病贫血治疗进展[J]. 临床医学进展, 2024, 14(8): 616-622. https://doi.org/10.12677/acm.2024.1482259

参考文献

[1] 李敬, 樊星, 王倩, 等. 罗沙司他治疗糖尿病肾病并发肾性贫血的疗效及安全性[J]. 中国新药与临床杂志, 2023, 42(5): 305-310.
[2] Astor, B.C., Muntner, P., Levin, A., Eustace, J.A. and Coresh, J. (2002) Association of Kidney Function with Anemia. Archives of Internal Medicine, 162, 1401-1408. [Google Scholar] [CrossRef] [PubMed]
[3] Li, Y., Shi, H., Wang, W., Peng, A., Jiang, G., Zhang, J., et al. (2016) Prevalence, Awareness, and Treatment of Anemia in Chinese Patients with Nondialysis Chronic Kidney Disease. Medicine, 95, e3872. [Google Scholar] [CrossRef] [PubMed]
[4] Locatelli, F., Minutolo, R., De Nicola, L. and Del Vecchio, L. (2022) Evolving Strategies in the Treatment of Anaemia in Chronic Kidney Disease: The HIF-Prolyl Hydroxylase Inhibitors. Drugs, 82, 1565-1589. [Google Scholar] [CrossRef] [PubMed]
[5] Feteh, V.F., Choukem, S., Kengne, A., Nebongo, D.N. and Ngowe-Ngowe, M. (2016) Anemia in Type 2 Diabetic Patients and Correlation with Kidney Function in a Tertiary Care Sub-Saharan African Hospital: A Cross-Sectional Study. BMC Nephrology, 17, Article No. 29. [Google Scholar] [CrossRef] [PubMed]
[6] Singh, D.K., Winocour, P. and Farrington, K. (2009) Erythropoietic Stress and Anemia in Diabetes Mellitus. Nature Reviews Endocrinology, 5, 204-210. [Google Scholar] [CrossRef] [PubMed]
[7] Grossman, C., Dovrish, Z., Koren-Morag, N., Bornstein, G. and Leibowitz, A. (2014) Diabetes Mellitus with Normal Renal Function Is Associated with Anaemia. Diabetes/Metabolism Research and Reviews, 30, 291-296. [Google Scholar] [CrossRef] [PubMed]
[8] Loutradis, C., Skodra, A., Georgianos, P., Tolika, P., Alexandrou, D., Avdelidou, A., et al. (2016) Diabetes Mellitus Increases the Prevalence of Anemia in Patients with Chronic Kidney Disease: A Nested Case-Control Study. World Journal of Nephrology, 5, 358-366. [Google Scholar] [CrossRef] [PubMed]
[9] Idris, I., Tohid, H., Muhammad, N.A., A Rashid, M.R., Mohd Ahad, A., Ali, N., Sharifuddin, N., et al. (2018) Anaemia among Primary Care Patients with Type 2 Diabetes Mellitus (T2DM) and Chronic Kidney Disease (CKD): A Multicentred Cross-Sectional Study. BMJ Open, 8, e025125. [Google Scholar] [CrossRef] [PubMed]
[10] McGill, J.B. and Bell, D.S.H. (2006) Anemia and the Role of Erythropoietin in Diabetes. Journal of Diabetes and its Complications, 20, 262-272. [Google Scholar] [CrossRef] [PubMed]
[11] 郑婧, 熊瑛, 张曙红, 等. 铁调素在肾性贫血中的研究进展[J]. 广西医科大学学报, 2023, 40(11): 1914-1920.
[12] Vota, D.M., Crisp, R.L., Nesse, A.B. and Vittori, D.C. (2012) Oxidative Stress Due to Aluminum Exposure Induces Eryptosis Which Is Prevented by Erythropoietin. Journal of Cellular Biochemistry, 113, 1581-1589. [Google Scholar] [CrossRef] [PubMed]
[13] 林小珍, 周静. 肾性贫血原因及相关机制的研究进展[J]. 南昌大学学报(医学版), 2022, 62(4): 95-101.
[14] 王勾琴, 周小春, 王俭勤. TGF-β_1相关microRNA在糖尿病肾病发病机制中的研究进展[J]. 医学综述, 2015, 21(19): 3548-3550.
[15] Vlahakos, D.V., Tsioufis, C., Manolis, A., Filippatos, G., Marathias, K.P., Papademetriou, V., et al. (2019) Inhibition of the Renin-Angiotensin System in the Cardiorenal Syndrome with Anaemia. Journal of Hypertension, 37, 2145-2153. [Google Scholar] [CrossRef] [PubMed]
[16] Donnelly, L.A., Dennis, J.M., Coleman, R.L., Sattar, N., Hattersley, A.T., Holman, R.R., et al. (2020) Risk of Anemia with Metformin Use in Type 2 Diabetes: A Mastermind Study. Diabetes Care, 43, 2493-2499. [Google Scholar] [CrossRef] [PubMed]
[17] UK Prospective Diabetes Study (UKPDS) Group (1998) Intensive Blood-Glucose Control with Sulphonylureas or Insulin Compared with Conventional Treatment and Risk of Complications in Patients with Type 2 Diabetes (UKPDS 33). The Lancet, 352, 837-853.
[18] UK Prospective DiabetesStudy (UKPDS) Group (1998) Effect of Intensive Blood-Glucose Control with Metformin on Complications in Overweight Patients with Type 2 Diabetes (UKPDS 34). The Lancet, 352, 854-865.
[19] Blicklé, J.F. (2001) Thiazolidinediones: Clinical Data and Perspectives. Diabetes & Metabolism Journal, 27, 279-285.
[20] Liu, K.W., Dai, L.K. and Jean, W. (2006) Metformin-Related Vitamin B12 Deficiency. Age and Ageing, 35, 200-201. [Google Scholar] [CrossRef] [PubMed]
[21] Bauman, W.A., Shaw, S., Jayatilleke, E., Spungen, A.M. and Herbert, V. (2000) Increased Intake of Calcium Reverses Vitamin B12 Malabsorption Induced by Metformin. Diabetes Care, 23, 1227-1231. [Google Scholar] [CrossRef] [PubMed]
[22] 陈晓洁, 王文健. 糖尿病肾病患者贫血的管理[J]. 中国实用内科杂志, 2023, 43(8): 649-654.
[23] Ogawa, C., Tsuchiya, K. and Maeda, K. (2023) Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors and Iron Metabolism. International Journal of Molecular Sciences, 24, Article 3037. [Google Scholar] [CrossRef] [PubMed]
[24] Fishbane, S., El-Shahawy, M.A., Pecoits-Filho, R., Van, B.P., Houser, M.T., Frison, L., et al. (2021) Roxadustat for Treating Anemia in Patients with CKD Not on Dialysis: Results from a Randomized Phase 3 Study. Journal of the American Society of Nephrology, 32, 737-755. [Google Scholar] [CrossRef] [PubMed]
[25] Zheng, Q., Yang, H., Fu, X., Huang, Y., Wei, R., Wang, Y., et al. (2020) The Efficacy and Safety of Roxadustat for Anemia in Patients with Chronic Kidney Disease: A Meta-Analysis. Nephrology Dialysis Transplantation, 36, 1603-1615. [Google Scholar] [CrossRef] [PubMed]
[26] 陈珩, 马俊龙, 唐励静. 罗沙司他与同类HIF-PHI及ESA在肾性贫血治疗中的分析比较[J]. 中南药学, 2022, 20(9): 2100-2105.
[27] Fishbane, S. and Spinowitz, B. (2018) Update on Anemia in ESRD and Earlier Stages of CKD: Core Curriculum 2018. American Journal of Kidney Diseases, 71, 423-435. [Google Scholar] [CrossRef] [PubMed]
[28] Thavarajah, S. and Choi, M.J. (2019) The Use of Erythropoiesis-Stimulating Agents in Patients with CKD and Cancer: A Clinical Approach. American Journal of Kidney Diseases, 74, 667-674. [Google Scholar] [CrossRef] [PubMed]
[29] Bhandari, S., Kalra, P.A., Berkowitz, M., Belo, D., Thomsen, L.L. and Wolf, M. (2020) Safety and Efficacy of Iron Isomaltoside 1000/Ferric Derisomaltose versus Iron Sucrose in Patients with Chronic Kidney Disease: The FERWON-NEPHRO Randomized, Open-Label, Comparative Trial. Nephrology Dialysis Transplantation, 36, 111-120. [Google Scholar] [CrossRef] [PubMed]

为你推荐