肾结石形成的机制研究进展
Research Progress on the Mechanism of Kidney Stone Formation
DOI: 10.12677/acm.2024.1482393, PDF,   
作者: 高云飞:内蒙古医科大学第一临床医学院,内蒙古 呼和浩特
关键词: 肾结石分子机制分类影响因素Kidney Stone Disease Molecular Mechanisms Classification Influence Factors
摘要: 肾结石是泌尿系统最常见的疾病之一。近年来,随着人们生活水平日益提升,肾结石的患病率急剧上升。且复发率高,首次结石发作后5年内复发率高达50%。因此预防结石的形成和复发意义重大。本综述旨在阐述目前已知的肾结石形成的机制,期望对早期预防结石形成及结石复发提供一定的帮助。
Abstract: Kidney stone disease is one of the most common diseases of the urinary system. In recent years, with the increasing improvement of people’s living standards, the prevalence of kidney stone disease has risen sharply. The recurrence rate is high, with a potential relapse rate reaching up to 50% within the first five years following the initial stone attack. Therefore, it is of great significance to prevent the formation and recurrence of stones. The purpose of this review is to explain the mechanism of kidney stone formation, and to provide some help for early prevention of stone formation and stone recurrence.
文章引用:高云飞. 肾结石形成的机制研究进展[J]. 临床医学进展, 2024, 14(8): 1576-1582. https://doi.org/10.12677/acm.2024.1482393

参考文献

[1] Sui, W., Hancock, J., Asplin, J.R., Gould, E.R. and Hsi, R.S. (2020) Nephrolithiasis and Elevated Urinary Ammonium: A Matched Comparative Study. Urology, 144, 77-82. [Google Scholar] [CrossRef] [PubMed]
[2] Wigner, P., Grębowski, R., Bijak, M., Szemraj, J. and Saluk-Bijak, J. (2021) The Molecular Aspect of Nephrolithiasis Development. Cells, 10, Article 1926. [Google Scholar] [CrossRef] [PubMed]
[3] 丁文龙, 刘学政, 孙晋浩, 等. 系统解剖学[M]. 第9版. 北京: 人民卫生出版社, 2018.
[4] 朱大年, 王庭槐, 罗自强, 等. 生理学[M]. 第9版. 北京: 人民卫生出版社, 2018.
[5] Kok, D.J. and Khan, S.R. (1994) Calcium Oxalate Nephrolithiasis, a Free or Fixed Particle Disease. Kidney International, 46, 847-854. [Google Scholar] [CrossRef] [PubMed]
[6] Khan, S.R., Rodriguez, D.E., Gower, L.B. and Monga, M. (2012) Association of Randall Plaque with Collagen Fibers and Membrane Vesicles. Journal of Urology, 187, 1094-1100. [Google Scholar] [CrossRef] [PubMed]
[7] D’Ambrosio, V., Ferraro, P.M., Lombardi, G., Friso, S. and Gambaro, G. (2022) Unravelling the Complex Relationship between Diet and Nephrolithiasis: The Role of Nutrigenomics and Nutrigenetics. Nutrients, 14, Article 4961. [Google Scholar] [CrossRef] [PubMed]
[8] Tavasoli, S. and Taheri, M. (2018) Vitamin D and Calcium Kidney Stones: A Review and a Proposal. International Urology and Nephrology, 51, 101-111. [Google Scholar] [CrossRef] [PubMed]
[9] 张立峰, 方志辉, 靳勇, 等. 影响泌尿系结石的多因素研究[J]. 黑龙江医药, 2015(1): 170-172.
[10] Negri, A.L., Spivacow, F.R., Del Valle, E.E., Forrester, M., Rosende, G. and Pinduli, I. (2008) Role of Overweight and Obesity on the Urinary Excretion of Promoters and Inhibitors of Stone Formation in Stone Formers. Urological Research, 36, 303-307. [Google Scholar] [CrossRef] [PubMed]
[11] Taguchi, K., Okada, A., Unno, R., Hamamoto, S. and Yasui, T. (2021) Macrophage Function in Calcium Oxalate Kidney Stone Formation: A Systematic Review of Literature. Frontiers in Immunology, 12, Article 673690. [Google Scholar] [CrossRef] [PubMed]
[12] Anders, H., Suarez-Alvarez, B., Grigorescu, M., Foresto-Neto, O., Steiger, S., Desai, J., et al. (2018) The Macrophage Phenotype and Inflammasome Component NLRP3 Contributes to Nephrocalcinosis-Related Chronic Kidney Disease Independent from Il-1-Mediated Tissue Injury. Kidney International, 93, 656-669. [Google Scholar] [CrossRef] [PubMed]
[13] Liu, Y., Sun, Y., Kang, J., He, Z., Liu, Q., Wu, J., et al. (2022) Role of Ros-Induced NLRP3 Inflammasome Activation in the Formation of Calcium Oxalate Nephrolithiasis. Frontiers in Immunology, 13, Article 818625. [Google Scholar] [CrossRef] [PubMed]
[14] Kim, M., Yang, J. and Jo, S. (2021) Intestinal Microbiota and Kidney Diseases. Kidney Research and Clinical Practice, 40, 335-343. [Google Scholar] [CrossRef] [PubMed]
[15] Karstens, L., Asquith, M., Caruso, V., Rosenbaum, J.T., Fair, D.A., Braun, J., et al. (2018) Community Profiling of the Urinary Microbiota: Considerations for Low-Biomass Samples. Nature Reviews Urology, 15, 735-749. [Google Scholar] [CrossRef] [PubMed]
[16] Zampini, A., Nguyen, A.H., Rose, E., Monga, M. and Miller, A.W. (2019) Defining Dysbiosis in Patients with Urolithiasis. Scientific Reports, 9, Article No. 5425. [Google Scholar] [CrossRef] [PubMed]
[17] Gao, H., Lin, J., Xiong, F., Yu, Z., Pan, S. and Huang, Y. (2022) Urinary Microbial and Metabolomic Profiles in Kidney Stone Disease. Frontiers in Cellular and Infection Microbiology, 12, Article 953392. [Google Scholar] [CrossRef] [PubMed]
[18] Tran, T.V.M. and Maalouf, N.M. (2020) Uric Acid Stone Disease: Lessons from Recent Human Physiologic Studies. Current Opinion in Nephrology & Hypertension, 29, 407-413. [Google Scholar] [CrossRef] [PubMed]
[19] Xu, L.H.R., Adams-Huet, B., Poindexter, J.R., Maalouf, N.M., Moe, O.W. and Sakhaee, K. (2017) Temporal Changes in Kidney Stone Composition and in Risk Factors Predisposing to Stone Formation. Journal of Urology, 197, 1465-1471. [Google Scholar] [CrossRef] [PubMed]
[20] Manish, K.C. and Leslie, S.W. (2024) Uric Acid Nephrolithiasis. StatPearls.
[21] Cohen, T.D. and Preminger, G.M. (1996) Struvite Calculi. Seminars in Nephrology, 16, 425-434.
[22] Trinchieri, A. (2014) Urinary Calculi and Infection. Urologia Journal, 81, 93-98. [Google Scholar] [CrossRef] [PubMed]
[23] Nagamori, S., Wiriyasermkul, P., Guarch, M.E., Okuyama, H., Nakagomi, S., Tadagaki, K., et al. (2016) Novel Cystine Transporter in Renal Proximal Tubule Identified as a Missing Partner of Cystinuria-Related Plasma Membrane Protein rBAT/SLC3A1. Proceedings of the National Academy of Sciences of the United States of America, 113, 775-780. [Google Scholar] [CrossRef] [PubMed]
[24] 李洪武. 肾结石的西医诊断综述[J]. 医学信息(中旬刊), 2011, 24(5): 2000-2001.
[25] Ray, A.A., Ghiculete, D., Pace, K.T. and Honey, R.J.D. (2010) Limitations to Ultrasound in the Detection and Measurement of Urinary Tract Calculi. Urology, 76, 295-300. [Google Scholar] [CrossRef] [PubMed]
[26] Smith-Bindman, R., Aubin, C., Bailitz, J., Bengiamin, R.N., Camargo, C.A., Corbo, J., et al. (2014) Ultrasonography versus Computed Tomography for Suspected Nephrolithiasis. New England Journal of Medicine, 371, 1100-1110. [Google Scholar] [CrossRef] [PubMed]
[27] Khan, S.R. (2010) Nephrocalcinosis in Animal Models with and without Stones. Urological Research, 38, 429-438. [Google Scholar] [CrossRef] [PubMed]
[28] Finlayson, B. (1978) Physicochemical Aspects of Urolithiasis. Kidney International, 13, 344-360. [Google Scholar] [CrossRef] [PubMed]