丹参酮IIA的药理作用及其在各类疾病治疗中的文献计量学分析
Pharmacological Effects of Tanshinone IIA and Bibliometric Analysis in the Treatment of Various Diseases
DOI: 10.12677/acm.2024.1482399, PDF,    国家自然科学基金支持
作者: 刘春花, 艾克拜尔江·艾赛提, 艾克热木江·木合热木*：新疆医科大学第六附属医院脊柱外科，新疆 乌鲁木齐；文天林*：北京中医药大学东直门医院骨伤科，北京
关键词: 丹参酮IIA；药理作用；文献计量学；心血管疾病；神经保护；Tanshinone IIA； Pharmacological Effects； Bibliometrics； Cardiovascular Disease； Neuroprotection
摘要: 丹参酮IIA (Tanshinone IIA, TanIIA)是从中药丹参中提取的主要有效成分之一，研究表明其在抗炎、抗氧化、抗肿瘤、心脏保护及神经系统保护方面具有显著的药理活性。本文采用文献计量学的方法，对国内外有关丹参酮IIA的研究进行分析，发现丹参酮IIA的研究是基于2000年至2024年间发表的13,681篇有关丹参酮IIA的文献的计量学分析；该领域发表研究论文最多的国家是中国，美国和澳大利亚，而发表论文最多的机构为中国医科大学，中国科学院和中山大学。丹参酮IIA在心血管疾病和神经系统疾病中的研究文献占比最高，研究类型主要以应用基础研究，临床研究和技术开发为主，出现频率最多的关键词为凋亡，表达，激活，氧化应激，炎症反应等，体现了其在这些领域的研究热度和临床应用价值。丹参酮IIA作为一种具有多重药理活性的中药成分，显示出广泛的临床应用前景，而当前研究的局限性和挑战需要我们在未来的研究中予以重视，通过多学科合作和创新研究方法，共同推动丹参酮IIA在疾病治疗中的进一步应用与发展。
Abstract: Tanshinone IIA (TanIIA) is one of the main active ingredients extracted from the traditional Chinese medicine Danshen, and studies have shown that it has significant pharmacological activities in anti-inflammatory, antioxidant, anti-tumor, cardioprotective and nervous system protection. In this paper, bibliometric methods were used to analyze the studies on tanshinone IIA at home and abroad, and found that the research on tanshinone IIA was based on quantitative analysis of 13,681 articles on tanshinone IIA published between 2000 and 2024. The countries with the most published research papers in this field are China, United States and Australia, while the institutions with the most published papers are China Medical University, Chinese Academy of Sciences and Sun Yat-sen University. Tanshinone IIA has the highest proportion of research literature in cardiovascular diseases and nervous system diseases, and the research types are mainly applied basic research, clinical research and technology development, and the most frequent keywords are apoptosis, expression, activation, oxidative stress, inflammatory response, etc., reflecting its research enthusiasm and clinical application value in these fields. As a traditional Chinese medicine ingredient with multiple pharmacological activities, tanshinone IIA has shown a wide range of clinical application prospects, but the limitations and challenges of current research need to be paid attention to in future research, and jointly promote the further application and development of tanshinone IIA in disease treatment through multidisciplinary cooperation and innovative research methods.
文章引用：刘春花, 艾克拜尔江·艾赛提, 艾克热木江·木合热木, 文天林. 丹参酮IIA的药理作用及其在各类疾病治疗中的文献计量学分析[J]. 临床医学进展, 2024, 14(8): 1625-1632. https://doi.org/10.12677/acm.2024.1482399

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