血尿酸/高密度脂蛋白胆固醇比值与糖尿病性视网膜病变的相关性

Correlation of Blood Uric Acid/High-Density Lipoprotein Cholesterol Ratio with Diabetic Retinopathy

摘要: 目的：探讨血尿酸/高密度脂蛋白胆固醇比值(UHR)与糖尿病性视网膜病变(DR)的相关性。方法：选择2023年3月~2024年3月于北华大学附属医院内分泌科住院的2型糖尿病患者共98例作为研究对象，收集临床资料及生化结果，计算BMI、UHR、甘油三酯/高密度脂蛋白胆固醇比值(TG/HDL-C)等结果；对单纯2型糖尿病组(T2DM) 34例2型糖尿病性视网膜病变组(DR) 64例变量行差异性分析；logistic回归分析筛选DR高危因素并绘制受试者工作特征曲线(ROC曲线)。结果：与T2DM组比较，DR组病程、血尿酸(SUA)、UHR、甘油三酯(TG)、TG/HDL-C水平升高(p < 0.05)，高密度脂蛋白(HDL-C)水平降低( p< 0.05)。logistic回归单因素显示SUA (OR: 1.007, 95% CI: 1.001~1.014)、UHR (OR: 2.576, 95% CI: 1.464~4.530)、TG (OR: 1.407, 95% CI: 1.004~1.971)、TG/HDL-C (OR: 1.418, 95% CI: 1.040~1.934)是DR发生的危险因素(p < 0.05)，HDL-C (OR：0.122，95% CI：0.020~0.763)是DR发生的保护性因素(p < 0.05)。多因素logistic回归分析显示UHR是DR发生的独立危险因素(p < 0.05)。ROC曲线显示，与TG、TG/HDL-C、SUA比较，UHR的ROC曲线下面积最大(AUC: 0.717, p < 0.05)。结论：UHR、SUA、TG、TG/HDL-C均为DR发生的危险因素，其中UHR对DR发生的预测价值最大。

Abstract: Objective: to investigate the correlation between blood uric acid/high-density lipoprotein cholesterol ratio (UHR) and diabetic retinopathy (DR). Methods: A total of 98 patients with type 2 diabetes mellitus who were hospitalized in the Department of Endocrinology of Beihua University Hospital from March 2023 to March 2024 were selected as the study subjects. Clinical data and biochemical results were collected, and the results of BMI, UHR, and triglyceride/high-density lipoprotein cholesterol ratio (TG/HDL-C) were calculated; for the 34 cases of type 2 diabetes mellitus in the type 2 diabetes mellitus group (T2DM) alone and the 64 cases in the diabetic retinopathy group (DR), the differences in variables were analyzed. Retinopathy group (DR) 64 cases were analyzed; logistic regression analysis was performed to screen the risk factors of DR and to draw the working characteristic curve (ROC curve) of the subjects. Results: Compared with the T2DM group, the DR group had increased disease duration, blood uric acid (SUA), UHR, triglyceride (TG), and TG/HDL-C levels (p < 0.05), and decreased high-density lipoprotein (HDL-C) levels (p < 0.05). logistic regression with a single factor showed that SUA (OR: 1.007, 95% CI: 1.001~1.014), UHR, and HDL were higher than the T2DM group. 1.014), UHR (OR: 2.576, 95% CI: 1.464~4.530), TG (OR: 1.407, 95% CI: 1.004~1.971), and TG/HDL-C (OR: 1.418, 95% CI: 1.040~1.934) were the risk factors for the development of DR (p < 0.05), HDL-C (OR: 0.122, 95% CI: 0.020~0.763) was a protective factor for DR occurrence (p < 0.05). Multifactorial logistic regression analysis showed that UHR was an independent risk factor for the occurrence of DR (p < 0.05). The ROC curve showed that UHR had the largest area under the ROC curve when compared with TG, TG/HDL-C, and SUA (AUC: 0.717, p < 0.05). Conclusion: UHR, SUA, TG, and TG/HDL-C are all risk factors for the development of DR, with UHR having the greatest predictive value for the development of DR.