抑郁症和双相情感障碍的患者甲状腺激素的水平分析及相关性研究

Analysis and Correlation of Thyroid Hormone Levels in Patients with Depression and Bipolar Disorder

摘要: 目的：探究抑郁症和双相情感障碍的病人甲状腺激素的水平变化及与心境障碍的相关性。方法：选择北京回龙观医院2023年1月至2024年3月收治的73例抑郁症患者、苏州市广济医院86例双相情感障碍患者、以及同期青岛市市立医院健康查体人员66例，作为研究对象，开展甲状腺功能五项水平检测，进行YMRS量表、HAMD抑郁量表的结果进行分析。比较观察抑郁症和双相情感障碍患者、健康查体人员的甲状腺激素水平，检测抑郁症、双相情感障碍患者在不同分组情况下的甲状腺功能五项检查水平情况，以及HAMD、YMRS的量表结果与甲状腺功能五项检查水平的相关性。结果：与健康查体者相比，抑郁症与双相情感障碍患者的甲状腺功能五项指标中，T3、FT3和FT4具有显著性统计学差异(P < 0.05)，T4、TSH无统计学差异(P > 0.05)。对于不同严重程度及是否伴有精神病性症状的抑郁症和双相情感障碍患者而言，双相情感障碍组别的患者甲状腺功能五项检查水平无统计学差异(P > 0.05)。抑郁症组别中不同组别的患者甲状腺功能五项检查水平存在统计学差异(P < 0.05)。在相关性方面，HAMD量表评分与T4、FT4有显著正相关性(r = 0.259, 0.176, P < 0.05)；YMRS量表评分与T3、TSH有显著的负相关性(r = −4.02, −0.466, P < 0.05)。结论：抑郁症和双相情感障碍的病人的甲状腺激素可见明显的异常表达，但就不同疾病程度的患者而言，不同程度抑郁症患者的甲状腺激素水平表达存在差异性，而不同程度的双相情感障碍患者的甲状腺激素的异常表达无差异性，通过对甲状腺五项功能的检测可对情感性精神障碍疾病患者的诊断具有一定的预测性，可为临床干预治疗的开展提供一定参考。

Abstract: Objective: To explore the major depressive disorder and bipolar disorder patients of thyroid hormone level change and relevance to mood disorders. Methods: Choosing Beijing Huilongguan hospital between January 2023 and March 2024, 73 patients with major depressive disorder, and 86 cases of patients with bipolar disorder in Suzhou Guangji Hospital, and in the same period of Qingdao municipal hospital healthy physical examination personnel 66 examples, as the research object, to carry out the five levels of thyroid function tests. The results of YMRS scale and HAMD depression scale were analyzed. The thyroid hormone levels of patients with major depressive disorder and bipolar disorder and healthy physical examination persons were compared. The levels of five thyroid function tests of patients with major depressive disorder and bipolar disorder in different groups were detected, and the correlation between the results of HAMD and YMRS and the levels of five thyroid function tests was analyzed. Results: Compared with healthy body, major depressive disorder and bipolar disorder in patients with thyroid function in the five indicators, T3, FT3 and FT4 with significant statistical difference (P < 0.05), T4, TSH, no statistical difference (P > 0.05). There was no significant difference in the levels of five thyroid function tests between bipolar disorder group and major depressive disorder group with different severity and with or without psychotic symptoms (P > 0.05). Thyroid function in patients with depression group different groups of five inspection level statistical differences (P < 0.05). In terms of relevance, HAMD rating scale and T4, FT4 had significant positive correlation (r = 0.259, 0.176, P < 0.05); there was a significant negative correlation between YMRS score and T3, TSH (r = −4.02, −0.466, P < 0.05). Conclusions: There are significant abnormal expressions of thyroid hormones in patients with depression and bipolar disorder, but there are differences in the expression of thyroid hormones in patients with different degrees of depression, but there is no difference in the abnormal expression of thyroid hormones in patients with different degrees of bipolar disorder. The detection of five thyroid functions has a certain predictive value for the diagnosis of patients with affective disorders, and can provide certain reference for the development of clinical intervention treatment.