儿童幽门螺杆菌相关胃肠外疾病表现的研究进展

Research Progress on the Manifestations of Helicobacter pylori Related Gastrointestinal Diseases in Children

摘要: 幽门螺杆菌(Helicobacter pylori, Hp)感染是人类最常见的感染之一，影响全球约三分之一的儿童。由于社会经济和卫生条件不同，感染率在不同的地区差异很大。有充分证据表明，Hp可引起胃肠道和胃肠外表现，后者在诊断和治疗方面是一大负担。Hp相关的全身性亚临床炎症是胃肠外疾病发展的主要原因，早期根除可预防与其发生相关的所有不良事件。近年来，Hp的感染情况引起了广泛的关注，许多研究表明，Hp可能与龋齿、哮喘、维生素缺乏症(D、B12、C)、肥胖、I型糖尿病以及头痛等疾病存在一定的联系，但是，目前尚无明确的定论。本文旨在总结近年来国内外关于Hp感染与某些胃肠外疾病关系及致病机制的研究成果进行综述。

Abstract: ^*通讯作者。Helicobacter pylori (Hp) infection is one of the most common human infections, affecting approxi-mately one-third of children worldwide. Due to differences in socio-economic and health conditions, the infection rate varies greatly in different regions. There is ample evidence to suggest that Hp can cause gastrointestinal and extra gastrointestinal manifestations, with the latter being a major burden in diagnosis and treatment. Systemic subclinical inflammation related to Hp is the main cause of the development of gastrointestinal diseases, and early eradication can prevent all adverse events associated with its occurrence. In recent years, the infection of Hp has aroused widespread concern. Many studies have shown that Hp may be associated with caries, asthma, vitamin deficiency (D, B12, C), obesity, type I diabetes, headache and other diseases, but there is no clear conclusion at present. This article aims to summarize the research results on the relationship and pathogenic mechanisms between Hp infection and certain gastrointestinal diseases at home and abroad in recent years.