微生物中邻氨基苯甲酸代谢与功能研究进展
The Metabolism and Functions of Anthranilic Acid in Microorganisms
DOI: 10.12677/amb.2024.133019, PDF,    国家自然科学基金支持
作者: 陈 博, 宋 凯, 何亚文：上海交通大学生命科学技术学院，微生物代谢国家重点实验室，教育部代谢与发育科学国际合作联合实验室，上海
关键词: 邻氨基苯甲酸；色氨酸合成；信号分子；跨界交流；Anthranilic Acid； Tryptophan Biosynthesis； Signaling Molecule； Interkingdom Communication
摘要: 邻氨基苯甲酸(Anthranilic acid, ATA)是微生物产生的一种小分子化合物，是色氨酸合成途径的中间产物。近年来一些研究发现ATA是一类信号分子，影响微生物生理功能。本文首先概述了大肠杆菌和酿酒酵母中ATA与色氨酸合成的关系，随后详细介绍了ATA在铜绿假单胞菌中的代谢与功能，以及ATA调控青枯雷尔氏菌的生理活动。最后结合其他微生物中ATA的最新研究结果，我们提出ATA可能参与微生物跨界交流。
Abstract: Anthranilic acid (ATA) is a small molecule produced by microorganisms and is an intermediate product of the tryptophan synthesis pathway. In recent years, it has been revealed that ATA is a new signaling molecule and has effects on microbial physiology. In this review, we first briefly outlined the relationship between ATA and tryptophan synthesis in Escherichia coli and Saccharomyces cerevisiae. We then summarized the metabolic network and biological functions of ATA in Pseudomonas aeruginosa, as well as the progress of ATA in regulating the physiology of Ralstonia solanacearum. Finally, we summarized the latest results describing the roles of ATA in other microorganisms and proposed that ATA may play a role in interkingdom communication.
文章引用：陈博, 宋凯, 何亚文. 微生物中邻氨基苯甲酸代谢与功能研究进展[J]. 微生物前沿, 2024, 13(3): 175-186. https://doi.org/10.12677/amb.2024.133019

参考文献

[1] Hwang, H., Li, X., Kim, S. and Lee, J. (2022) Anthranilate Acts as a Signal to Modulate Biofilm Formation, Virulence, and Antibiotic Tolerance of Pseudomonas aeruginosa and Surrounding Bacteria. Microbiology Spectrum, 10, e01463-21. [Google Scholar] [CrossRef] [PubMed]
[2] Song, S., Yin, W., Sun, X., Cui, B., Huang, L., Li, P., et al. (2020) Anthranilic Acid from Ralstonia solanacearum Plays Dual Roles in Intraspecies Signalling and Inter-Kingdom Communication. The ISME Journal, 14, 2248-2260. [Google Scholar] [CrossRef] [PubMed]
[3] Ren, X., Wei, Y., Zhao, H., Shao, J., Zeng, F., Wang, Z., et al. (2023) A Comprehensive Review and Comparison of L-Tryptophan Biosynthesis in Saccharomyces cerevisiae and Escherichia coli. Frontiers in Bioengineering and Biotechnology, 11, Article 1261832. [Google Scholar] [CrossRef] [PubMed]
[4] Panozzo, C., Nawara, M., Suski, C., Kucharczyk, R., Skoneczny, M., Bécam, A., et al. (2002) Aerobic and Anaerobic NAD+ Metabolism in Saccharomyces cerevisiae. FEBS Letters, 517, 97-102. [Google Scholar] [CrossRef] [PubMed]
[5] Kato, M. and Lin, S. (2014) Regulation of NAD+ Metabolism, Signaling and Compartmentalization in the Yeast Saccharomyces cerevisiae. DNA Repair, 23, 49-58. [Google Scholar] [CrossRef] [PubMed]
[6] Cigana, C., Lorè, N.I., Bernardini, M.L. and Bragonzi, A. (2011) Dampening Host Sensing and Avoiding Recognition in Pseudomonas aeruginosa Pneumonia. BioMed Research International, 2011, Article ID: 852513. [Google Scholar] [CrossRef] [PubMed]
[7] Parkins, M.D., Somayaji, R. and Waters, V.J. (2018) Epidemiology, Biology, and Impact of Clonal Pseudomonas aeruginosa Infections in Cystic Fibrosis. Clinical Microbiology Reviews, 31, e00019. [Google Scholar] [CrossRef] [PubMed]
[8] Lee, J. and Zhang, L. (2014) The Hierarchy Quorum Sensing Network in Pseudomonas aeruginosa. Protein & Cell, 6, 26-41. [Google Scholar] [CrossRef] [PubMed]
[9] Lin, J., Cheng, J., Wang, Y. and Shen, X. (2018) The Pseudomonas Quinolone Signal (PQS): Not Just for Quorum Sensing Anymore. Frontiers in Cellular and Infection Microbiology, 8, Article 230. [Google Scholar] [CrossRef] [PubMed]
[10] Bredenbruch, F., Nimtz, M., Wray, V., Morr, M., Müller, R. and Häussler, S. (2005) Biosynthetic Pathway of Pseudomonas aeruginosa 4-Hydroxy-2-Alkylquinolines. Journal of Bacteriology, 187, 3630-3635. [Google Scholar] [CrossRef] [PubMed]
[11] Cao, H., Krishnan, G., Goumnerov, B., Tsongalis, J., Tompkins, R. and Rahme, L.G. (2001) A Quorum Sensing-Associated Virulence Gene of Pseudomonas aeruginosa Encodes a LysR-Like Transcription Regulator with a Unique Self-Regulatory Mechanism. Proceedings of the National Academy of Sciences of the United States of America, 98, 14613-14618. [Google Scholar] [CrossRef] [PubMed]
[12] Essar, D.W., Eberly, L., Hadero, A. and Crawford, I.P. (1990) Identification and Characterization of Genes for a Second Anthranilate Synthase in Pseudomonas aeruginosa: Interchangeability of the Two Anthranilate Synthases and Evolutionary Implications. Journal of Bacteriology, 172, 884-900. [Google Scholar] [CrossRef] [PubMed]
[13] Essar, D.W., Eberly, L., Han, C.Y. and Crawford, I.P. (1990) DNA Sequences and Characterization of Four Early Genes of the Tryptophan Pathway in Pseudomonas aeruginosa. Journal of Bacteriology, 172, 853-866. [Google Scholar] [CrossRef] [PubMed]
[14] Palmer, G.C., Jorth, P.A. and Whiteley, M. (2013) The Role of Two Pseudomonas aeruginosa Anthranilate Synthases in Tryptophan and Quorum Signal Production. Microbiology, 159, 959-969. [Google Scholar] [CrossRef] [PubMed]
[15] Cervenka, I., Agudelo, L.Z. and Ruas, J.L. (2017) Kynurenines: Tryptophan’s Metabolites in Exercise, Inflammation, and Mental Health. Science, 357, eaaf9794. [Google Scholar] [CrossRef] [PubMed]
[16] Platten, M., Nollen, E.A.A., Röhrig, U.F., Fallarino, F. and Opitz, C.A. (2019) Tryptophan Metabolism as a Common Therapeutic Target in Cancer, Neurodegeneration and Beyond. Nature Reviews Drug Discovery, 18, 379-401. [Google Scholar] [CrossRef] [PubMed]
[17] Kurnasov, O., Jablonski, L., Polanuyer, B., Dorrestein, P., Begley, T. and Osterman, A. (2003) Aerobic Tryptophan Degradation Pathway in Bacteria: Novel Kynurenine Formamidase. FEMS Microbiology Letters, 227, 219-227. [Google Scholar] [CrossRef] [PubMed]
[18] Lima, W.C., Varani, A.M. and Menck, C.F.M. (2008) NAD Biosynthesis Evolution in Bacteria: Lateral Gene Transfer of Kynurenine Pathway in Xanthomonadales and Flavobacteriales. Molecular Biology and Evolution, 26, 399-406. [Google Scholar] [CrossRef] [PubMed]
[19] Farrow, J.M. and Pesci, E.C. (2007) Two Distinct Pathways Supply Anthranilate as a Precursor of the Pseudomonas Quinolone Signal. Journal of Bacteriology, 189, 3425-3433. [Google Scholar] [CrossRef] [PubMed]
[20] Knoten, C.A., Hudson, L.L., Coleman, J.P., Farrow, J.M. and Pesci, E.C. (2011) KynR, a Lrp/AsnC-Type Transcriptional Regulator, Directly Controls the Kynurenine Pathway in Pseudomonas aeruginosa. Journal of Bacteriology, 193, 6567-6575. [Google Scholar] [CrossRef] [PubMed]
[21] Palmer, K.L., Aye, L.M. and Whiteley, M. (2007) Nutritional Cues Control Pseudomonas aeruginosa Multicellular Behavior in Cystic Fibrosis Sputum. Journal of Bacteriology, 189, 8079-8087. [Google Scholar] [CrossRef] [PubMed]
[22] Coleman, J.P., Hudson, L.L., McKnight, S.L., Farrow, J.M., Calfee, M.W., Lindsey, C.A., et al. (2008) Pseudomonas aeruginosa PqsA Is an Anthranilate-Coenzyme A Ligase. Journal of Bacteriology, 190, 1247-1255. [Google Scholar] [CrossRef] [PubMed]
[23] Dulcey, C.E., Dekimpe, V., Fauvelle, D., Milot, S., Groleau, M., Doucet, N., et al. (2013) The End of an Old Hypothesis: The Pseudomonas Signaling Molecules 4-Hydroxy-2-Alkylquinolines Derive from Fatty Acids, Not 3-Ketofatty Acids. Chemistry & Biology, 20, 1481-1491. [Google Scholar] [CrossRef] [PubMed]
[24] Drees, S.L. and Fetzner, S. (2015) PqsE of Pseudomonas aeruginosa Acts as Pathway-Specific Thioesterase in the Biosynthesis of Alkylquinolone Signaling Molecules. Chemistry & Biology, 22, 611-618. [Google Scholar] [CrossRef] [PubMed]
[25] Drees, S.L., Li, C., Prasetya, F., Saleem, M., Dreveny, I., Williams, P., et al. (2016) PqsBC, a Condensing Enzyme in the Biosynthesis of the Pseudomonas aeruginosa Quinolone Signal: Crystal Structure, Inhibition, and Reaction Mechanism. Journal of Biological Chemistry, 291, 6610-6624. [Google Scholar] [CrossRef] [PubMed]
[26] Schertzer, J.W., Brown, S.A. and Whiteley, M. (2010) Oxygen Levels Rapidly Modulate Pseudomonas aeruginosa Social Behaviours via Substrate Limitation of PqsH. Molecular Microbiology, 77, 1527-1538. [Google Scholar] [CrossRef] [PubMed]
[27] Ilangovan, A., Fletcher, M., Rampioni, G., Pustelny, C., Rumbaugh, K., Heeb, S., et al. (2013) Structural Basis for Native Agonist and Synthetic Inhibitor Recognition by the Pseudomonas aeruginosa Quorum Sensing Regulator PqsR (MvfR). PLOS Pathogens, 9, e1003508. [Google Scholar] [CrossRef] [PubMed]
[28] Montagut, E.J. and Marco, M.P. (2021) Biological and Clinical Significance of Quorum Sensing Alkylquinolones: Current Analytical and Bioanalytical Methods for Their Quantification. Analytical and Bioanalytical Chemistry, 413, 4599-4618. [Google Scholar] [CrossRef] [PubMed]
[29] Choi, Y., Park, H., Park, S.J., Park, S., Kim, S., Ha, C., et al. (2011) Growth Phase-Differential Quorum Sensing Regulation of Anthranilate Metabolism in Pseudomonas aeruginosa. Molecules and Cells, 32, 57-66. [Google Scholar] [CrossRef] [PubMed]
[30] Costaglioli, P., Barthe, C., Claverol, S., Brözel, V.S., Perrot, M., Crouzet, M., et al. (2012) Evidence for the Involvement of the Anthranilate Degradation Pathway in Pseudomonas aeruginosa Biofilm Formation. MicrobiologyOpen, 1, 326-339. [Google Scholar] [CrossRef] [PubMed]
[31] Oglesby, A.G., Farrow, J.M., Lee, J., Tomaras, A.P., Greenberg, E.P., Pesci, E.C., et al. (2008) The Influence of Iron on Pseudomonas aeruginosa Physiology: A Regulatory Link between Iron and Quorum Sensing. Journal of Biological Chemistry, 283, 15558-15567. [Google Scholar] [CrossRef] [PubMed]
[32] Kim, S., Im, S., Yeom, D. and Lee, J. (2012) AntR-mediated Bidirectional Activation of antA and antR, Anthranilate Degradative Genes in Pseudomonas aeruginosa. Gene, 505, 146-152. [Google Scholar] [CrossRef] [PubMed]
[33] Moreau-Marquis, S., Stanton, B.A. and O’Toole, G.A. (2008) Pseudomonas aeruginosa Biofilm Formation in the Cystic Fibrosis Airway. Pulmonary Pharmacology & Therapeutics, 21, 595-599. [Google Scholar] [CrossRef] [PubMed]
[34] Yang, L., Haagensen, J.A.J., Jelsbak, L., Johansen, H.K., Sternberg, C., Høiby, N., et al. (2008) In Situ Growth Rates and Biofilm Development of Pseudomonas aeruginosa Populations in Chronic Lung Infections. Journal of Bacteriology, 190, 2767-2776. [Google Scholar] [CrossRef] [PubMed]
[35] Kim, S., Park, H. and Lee, J. (2015) Anthranilate Deteriorates the Structure of Pseudomonas aeruginosa Biofilms and Antagonizes the Biofilm-Enhancing Indole Effect. Applied and Environmental Microbiology, 81, 2328-2338. [Google Scholar] [CrossRef] [PubMed]
[36] Li, X., Kim, S. and Lee, J. (2017) Anti-Biofilm Effects of Anthranilate on a Broad Range of Bacteria. Scientific Reports, 7, Article No. 8604. [Google Scholar] [CrossRef] [PubMed]
[37] Song, S., Sun, X., Guo, Q., Cui, B., Zhu, Y., Li, X., et al. (2022) An Anthranilic Acid-Responsive Transcriptional Regulator Controls the Physiology and Pathogenicity of Ralstonia solanacearum. PLOS Pathogens, 18, e1010562. [Google Scholar] [CrossRef] [PubMed]
[38] Chen, Y., Fu, Y., Xia, Y., Miao, Y., Shao, J., Xuan, W., et al. (2024) Trichoderma-Secreted Anthranilic Acid Promotes Lateral Root Development via Auxin Signaling and RBOHF-Induced Endodermal Cell Wall Remodeling. Cell Reports, 43, Article ID: 114030. [Google Scholar] [CrossRef] [PubMed]
[39] Matsumoto, H., Fan, X., Wang, Y., Kusstatscher, P., Duan, J., Wu, S., et al. (2021) Bacterial Seed Endophyte Shapes Disease Resistance in Rice. Nature Plants, 7, 60-72. [Google Scholar] [CrossRef] [PubMed]

为你推荐