经鼻蝶入路神经内镜下切除垂体瘤术后脑脊液鼻漏的研究进展

Research Advancements in Cerebrospinal Fluid Rhinorrhea Following Neuroendoscopic Removal of Pituitary Tumor via Nasal Transsphenoidal Approach

摘要: 神经内镜切除垂体瘤在临床中的应用越来越广泛，相比显微镜下手术，切口微创，术后恢复快，但术中易造成的颅底结构破坏常导致脑脊液漏的发生。脑脊液鼻漏系指脑脊液经破裂或缺损的蛛网膜、硬脑膜和颅底骨板流入鼻腔或鼻窦。由于术中不能及时发现漏口，会导致术后出现脑脊液鼻漏，从而引发一系列相关并发症。本文分析术后脑脊液鼻漏的相关危险因素研究进展进行综述，为临床提供参考。

Abstract: Neuroendoscopic removal of pituitary tumors is increasingly utilized in clinical settings. Compared to microsurgery, this technique offers less invasive incisions and faster postoperative recovery, yet it often results in damage to the skull base structure, which can lead to cerebrospinal fluid leakage. Cerebrospinal fluid rhinorrhea occurs when cerebrospinal fluid flows into the nasal cavity or sinuses through a ruptured or damaged arachnoid membrane, dura mater, or skull base bone. Failing to promptly identify the leak during surgery can result in postoperative cerebrospinal fluid rhinorrhea, which can trigger a host of related complications. This article reviews the advancements in research on the risk factors associated with postoperative cerebrospinal fluid rhinorrhea, offering insights for clinical reference.