炎症相关标志物及抗炎治疗在主动脉夹层中的研究现状
Research Status of Inflammation-Related Markers and Anti-Inflammatory Treatment in Aortic Dissection
摘要: 手术治疗仍然是主动脉夹层首要的治疗措施,主动脉夹层患者,即使在高致命性急性期幸存下来,慢性组织破坏也经常导致主动脉并发症,并影响预后。因此发现并及时干预影响主动脉夹层患者预后的相关因素至关重要。炎症反应已被证实促进主动脉夹层的发生和发展,主动脉在较长时间内处于炎症状态,是一个潜在的治疗靶点。该文章整理了国内外相关文献,总结近年来炎症相关标志物及抗炎治疗在主动脉夹层中的研究现状,为疾病的预防和治疗提供一定的参考。
Abstract: Surgical treatment is still the first for the treatment of aortic dissection, in patients with aortic dissection, even if they survive the highly lethal acute phase, chronic tissue destruction often leads to aortic complications and affects prognosis. Therefore, it is very important to find and timely intervene the related factors affecting the prognosis of patients with aortic dissection. The inflammatory response has been confirmed to promote the occurrence and development of aortic dissection, and the aorta is in an inflammatory state for a long time, which is a potential therapeutic target. This article reviews the relevant literature, summarizes the research status of inflammation-related markers and anti-inflammatory treatment in aortic dissection in recent years, and provides some reference for the prevention and treatment of the disease.
文章引用:阿斯依古丽·吐尔孙, 玉素甫江·牙库甫. 炎症相关标志物及抗炎治疗在主动脉夹层中的研究现状[J]. 临床医学进展, 2024, 14(9): 1018-1024. https://doi.org/10.12677/acm.2024.1492561

参考文献

[1] Carrel, T., Sundt, T.M., von Kodolitsch, Y. and Czerny, M. (2023) Acute Aortic Dissection. The Lancet, 401, 773-788. [Google Scholar] [CrossRef] [PubMed]
[2] 中国心血管健康与疾病报告编写组. 《中国心血管健康与疾病报告2022》概要[J]. 中国介入心脏病学杂志, 2023, 31(7): 485-508.
[3] 冯小航, 樊天斐, 侯杨峰, 等. 炎性细胞和主动脉固有细胞在主动脉夹层中的研究现状[J]. 中华心血管病杂志, 2023, 51(1): 92-98.
[4] Ju, X., Ijaz, T., Sun, H., Ray, S., Lejeune, W., Lee, C., et al. (2013) Interleukin-6-Signal Transducer and Activator of Transcription-3 Signaling Mediates Aortic Dissections Induced by Angiotensin II via the T-Helper Lymphocyte 17–interleukin 17 Axis in C57BL/6 Mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 33, 1612-1621. [Google Scholar] [CrossRef] [PubMed]
[5] Tieu, B.C., Lee, C., Sun, H., LeJeune, W., Recinos, A., Ju, X., et al. (2009) An Adventitial IL-6/MCP1 Amplification Loop Accelerates Macrophage-Mediated Vascular Inflammation Leading to Aortic Dissection in Mice. Journal of Clinical Investigation, 119, 3637-3651. [Google Scholar] [CrossRef] [PubMed]
[6] O’Shea, J.J., Schwartz, D.M., Villarino, A.V., Gadina, M., McInnes, I.B. and Laurence, A. (2015) The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention. Annual Review of Medicine, 66, 311-328. [Google Scholar] [CrossRef] [PubMed]
[7] 赵洁, 吴俊, 贾玫. 冠心病患者血液脂蛋白相关磷脂酶A2与超敏C反应蛋白及D-二聚体的相关性研究[J]. 中华检验医学杂志, 2014, 37(3): 227-229
[8] Yeh, E.T.H. (2005) High-sensitivity C-Reactive Protein as a Risk Assessment Tool for Cardiovascular Disease. Clinical Cardiology, 28, 408-412. [Google Scholar] [CrossRef] [PubMed]
[9] Vrsalović, M. and Vrsalović Presečki, A. (2019) Admission C-Reactive Protein and Outcomes in Acute Aortic Dissection: A Systematic Review. Croatian Medical Journal, 60, 309-315. [Google Scholar] [CrossRef] [PubMed]
[10] Sugano, Y., Anzai, T., Yoshikawa, T., Satoh, T., Iwanaga, S., Hayashi, T., et al. (2005) Serum C-Reactive Protein Elevation Predicts Poor Clinical Outcome in Patients with Distal Type Acute Aortic Dissection: Association with the Occurrence of Oxygenation Impairment. International Journal of Cardiology, 102, 39-45. [Google Scholar] [CrossRef] [PubMed]
[11] 汤庆, 李松, 钟元锋, 等. 血清降钙素原在Stanford A型主动脉夹层患者术后肺部感染的预测及预后评估价值[J]. 检验医学与临床, 2020, 17(16): 2318-2321.
[12] Liu, D., Chen, Y., Wang, Y., Lei, M., Chen, L., Liang, R., et al. (2020) Combination of Serum Amyloid a and C-Reactive Protein Exhibit Synergistic Effect in Angiogenesis by Inducing Inflammation and Vascular Network. Frontiers in Oncology, 10, Article 576207. [Google Scholar] [CrossRef] [PubMed]
[13] Wang, M., Gai, M., Wang, B., Maituxun, M., Yesitayi, G., Chen, B., et al. (2023) The Diagnostic and Prognostic Value of SAA1 as a Novel Biomarker for Acute Aortic Dissection. Journal of Proteomics, 286, Article ID: 104958. [Google Scholar] [CrossRef] [PubMed]
[14] Chen, Z.R., Huang, B., Lu, H.S., et al. (2017) Admission White Blood Cell Count Predicts Short-Term Clinical Outcomes in Patients with Uncomplicated Stanford Type B Acute Aortic Dissection. Journal of Geriatric Cardiology: JGC, 14, 49-56.
[15] Kurihara, T., Shimizu-Hirota, R., Shimoda, M., Adachi, T., Shimizu, H., Weiss, S.J., et al. (2012) Neutrophil-derived Matrix Metalloproteinase 9 Triggers Acute Aortic Dissection. Circulation, 126, 3070-3080. [Google Scholar] [CrossRef] [PubMed]
[16] Xu, L. and Burke, A. (2013) Acute Medial Dissection of the Ascending Aorta: Evolution of Reactive Histologic Changes. American Journal of Surgical Pathology, 37, 1275-1282. [Google Scholar] [CrossRef] [PubMed]
[17] Sadik, C.D., Kim, N.D. and Luster, A.D. (2011) Neutrophils Cascading Their Way to Inflammation. Trends in Immunology, 32, 452-460. [Google Scholar] [CrossRef] [PubMed]
[18] Anzai, A., Shimoda, M., Endo, J., Kohno, T., Katsumata, Y., Matsuhashi, T., et al. (2015) Adventitial CXCL1/G-CSF Expression in Response to Acute Aortic Dissection Triggers Local Neutrophil Recruitment and Activation Leading to Aortic Rupture. Circulation Research, 116, 612-623. [Google Scholar] [CrossRef] [PubMed]
[19] Horne, B.D., Anderson, J.L., John, J.M., Weaver, A., Bair, T.L., Jensen, K.R., et al. (2005) Which White Blood Cell Subtypes Predict Increased Cardiovascular Risk? Journal of the American College of Cardiology, 45, 1638-1643. [Google Scholar] [CrossRef] [PubMed]
[20] Yang, F., Liu, J., Chen, L., Fan, R., Zeng, H., Geng, Q., et al. (2021) Impact of Lymphocyte-Related Blood Parameters on Short-and Long-Term Outcomes of Patients Undergoing Thoracic Endovascular Aortic Repair. Angiology, 72, 953-960. [Google Scholar] [CrossRef] [PubMed]
[21] 姬虹宇, 孟凡华, 李华垠, 等. 中性粒细胞/淋巴细胞比值与急性主动脉夹层患者短期预后关系的Meta分析[J]. 中国循证医学杂志, 2022, 22(1): 67-72.
[22] Zhao, Y., Jiang, J., Yuan, Y., Shu, X., Wang, E., Fu, W., et al. (2023) Prognostic Value of the Systemic Immune Inflammation Index after Thoracic Endovascular Aortic Repair in Patients with Type B Aortic Dissection. Disease Markers, 2023, Article ID: 2126882. [Google Scholar] [CrossRef] [PubMed]
[23] Li, X., Liu, D., Zhao, L., Wang, L., Li, Y., Cho, K., et al. (2020) Targeted Depletion of Monocyte/Macrophage Suppresses Aortic Dissection with the Spatial Regulation of MMP-9 in the Aorta. Life Sciences, 254, Article ID: 116927. [Google Scholar] [CrossRef] [PubMed]
[24] Tomida, S., Aizawa, K., Nishida, N., Aoki, H., Imai, Y., Nagai, R., et al. (2019) Indomethacin Reduces Rates of Aortic Dissection and Rupture of the Abdominal Aorta by Inhibiting Monocyte/Macrophage Accumulation in a Murine Model. Scientific Reports, 9, Article No. 10751. [Google Scholar] [CrossRef] [PubMed]
[25] Pape, L.A., Awais, M., Woznicki, E.M., et al. (2015) Presentation, Diagnosis, and Outcomes of Acute Aortic Dissection: 17-Year Trends from the International Registry of Acute Aortic Dissection. Journal of the American College of Cardiology, 66, 350-358.
[26] Malaisrie, S.C., Szeto, W.Y., Halas, M., Girardi, L.N., Coselli, J.S., Sundt, T.M., et al. (2021) 2021 the American Association for Thoracic Surgery Expert Consensus Document: Surgical Treatment of Acute Type A Aortic Dissection. The Journal of Thoracic and Cardiovascular Surgery, 162, 735-758.e2. [Google Scholar] [CrossRef] [PubMed]
[27] Kume, N., Cybulsky, M.I. and Gimbrone, M.A. (1992) Lysophosphatidylcholine, a Component of Atherogenic Lipoproteins, Induces Mononuclear Leukocyte Adhesion Molecules in Cultured Human and Rabbit Arterial Endothelial Cells. Journal of Clinical Investigation, 90, 1138-1144. [Google Scholar] [CrossRef] [PubMed]
[28] Tsigkou, V., Siasos, G., Bletsa, E., Panoilia, M., Papastavrou, A., Kokosias, G., et al. (2018) Statins in Aortic Disease. Current Pharmaceutical Design, 23, 7109-7120. [Google Scholar] [CrossRef] [PubMed]
[29] Astrup, T. and Nissen, U. (1964) Urinary Trypsin Inhibitor (Mingin): Transformation into a New Trypsin Inhibitor by Acid Hydrolysis or by Sialidase. Nature, 203, 255-257. [Google Scholar] [CrossRef] [PubMed]
[30] Zhenyu, H., Qiaoli, Y., Guangxiang, C. and Maohua, W. (2022) The Effect of Ulinastatin on Postoperative Course in Cardiopulmonary Bypass Patients in Asia: A Meta-Analysis of Randomized Controlled Trials. Journal of Cardiothoracic Surgery, 17, Article No. 66. [Google Scholar] [CrossRef] [PubMed]
[31] Liu, H., Sun, B., Tang, Z., Qian, S., Zheng, S., Wang, Q., et al. (2024) Anti-inflammatory Response-Based Risk Assessment in Acute Type A Aortic Dissection: A National Multicenter Cohort Study. IJC Heart & Vasculature, 50, Article ID: 101341. [Google Scholar] [CrossRef] [PubMed]
[32] Sun, Y., Ding, X., Cui, Y., Li, H., Wang, D., Liang, H., et al. (2022) Positive Effects of Neutrophil Elastase Inhibitor (Sivelestat) on Gut Microbiome and Metabolite Profiles of Septic Rats. Frontiers in Cellular and Infection Microbiology, 12, Article 818391. [Google Scholar] [CrossRef] [PubMed]
[33] Maki, C., Inoue, Y., Ishihara, T., Hirano, Y., Kondo, Y., Sueyoshi, K., et al. (2019) Evaluation of Appropriate Indications for the Use of Sivelestat Sodium in Acute Respiratory Distress Syndrome: A Retrospective Cohort Study. Acute Medicine & Surgery, 7, e471. [Google Scholar] [CrossRef] [PubMed]
[34] Inoue, N., Oka, N., Kitamura, T., Shibata, K., Itatani, K., Tomoyasu, T., et al. (2013) Neutrophil Elastase Inhibitor Sivelestat Attenuates Perioperative Inflammatory Response in Pediatric Heart Surgery with Cardiopulmonary Bypass. International Heart Journal, 54, 149-153. [Google Scholar] [CrossRef] [PubMed]
[35] Zhou, Y., Li, X., Chen, H., Zhong, X. and Ren, H. (2022) Efficacy and Safety of Sivelestat Sodium for the Treatment of Inflammatory Response in Acute Stanford Type A Aortic Dissection: A Retrospective Cohort Study. Journal of Thoracic Disease, 14, 3975-3982. [Google Scholar] [CrossRef] [PubMed]