安罗替尼治疗乳腺叶状肿瘤肺转移达临床完全缓解一例

A Case of Clinical Complete Response in Lung Metastasis of Breast Phyllodes Tumor Treated with Anlotinib

摘要: 乳腺叶状肿瘤是一种罕见的疾病，主要发生在女性中。在亚洲女性中，该病的发病年龄较早，平均发病年龄为25~30岁。乳腺叶状肿瘤(PT)可表现为远处转移，恶性PT的远处转移率可高达22%。最常见的转移部位是肺部。我们报告了一例27岁的患者，因左侧乳房出现巨大肿块就诊，该肿块在过去三个月内迅速生长。随后对左侧乳房进行了全乳切除术，病理诊断为恶性叶状肿瘤。术后一个月，患者出现肺部转移。患者拒绝了化疗，并在接受安罗替尼治疗后，肺部转移灶逐渐缩小，最终消失，显示出临床完全缓解。安罗替尼可能为恶性转移性叶状肿瘤提供一种安全有效的治疗方案。

Abstract: Breast phyllodes tumor is a rare disease that occurs in women. In Asian women, the onset of the disease occurs earlier, with an average age of 25~30 years. PT can exhibit distant metastasis, with a distant metastasis rate of up to 22% in malignant PT. The most metastases is found in the lungs. We report a case of a 27-year-old patient who presented a voluminous breast mass, rapidly growing in the past 3 months. Total mastectomy of left breast was performed thereafter, and pathology diagnosis was malignant phyllodes tumor. The patient developed lung metastasis one month after surgery. The patient refused chemotherapy and after treatment with anlotinib, the lung metastasis gradually narrowed and eventually disappeared, showing complete clinical response. Anlotinib may provide a safe and effective treatment regimen for malignant metastatic phyllodes tumor.