桥本氏甲状腺炎对肥胖患者卵巢储备功能的影响

Effect of Hashimoto’s Thyroiditis on Ovarian Reserve Function in Obese Patients

摘要: 目的：探讨桥本氏甲状腺炎(HT)是否会导致肥胖患者的卵巢储备功能下降。方法：选取黑龙江中医药大学附属第一医院内分泌科门诊系统中2017年7月~2018年10月共计189例，符合《中国成人肥胖症防治专家共识》诊断标准的肥胖患者作为研究对象进行回顾性研究；分析肥胖 + HT患者与肥胖 + 非HT患者之间一般临床特征、糖脂代谢指标、甲状腺功能指标、抗苗勒管激素(AMH)的差异，以及AMH与甲状腺功能指标相关性。结果：肥胖 + HT组与肥胖 + 非HT组间HDL、脂蛋白a、TSH、TG-AB、APO-AB，差异具有显著性(P < 0.05)。结论：HT是否会降低肥胖患者卵巢储备的能力，仍需进一步研究探索；HT可能会加重肥胖患者卵泡发育受抑制情况，增加肥胖患者月经周期紊乱的风险。

Abstract: Objective: To investigate whether Hashimoto’s thyroiditis (HT) can lead to the decline of ovarian reserve function in obese patients. Methods: A retrospective study was conducted on 189 obese patients who met the diagnostic criteria of China Adult Obesity Prevention and Treatment Expert Consensus from July 2017 to October 2018 in the outpatient system of endocrinology department of the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine. To analyze the differences between obese + HT patients and obese + non-HT patients in general clinical features, glucose and lipid metabolism indexes, thyroid function indexes and anti-Mullerian hormone (AMH), and the correlation between AMH and thyroid function indexes. Results: There were significant differences in HDL, lipoprotein A, TSH, TG-AB and APO-AB between obese + HT group and obese + non-HT group (P < 0.05). Results: Whether HT can reduce the ability of ovarian reserve in obese patients still needs further study and exploration. HT may aggravate the inhibition of follicular development in obese patients and increase the risk of menstrual cycle disorder in obese patients.