基于数据挖掘分析中医药治疗异位妊娠的用药规律

Analysing the Medication Pattern of Traditional Chinese Medicine in the Treatment of Ectopic Pregnancy Based on Data Mining

摘要: 目的：通过数据挖掘及分析探讨中医药治疗异位妊娠的临床运用现况及规律。方法：系统搜集中国知网(CNKI)、万方数据知识服务平台(Wanfang Data)、维普(CQVIP)等数据库自2010年1月~2023年12月中医药治疗异位妊娠的临床研究文献，运用Excel进行规范化统计，并将规范化后的药方材料输入“中医传承辅助平台(V2.5)”后予统算剖析，对用药频次、性味归经、组方规律和新处方的统算剖析，总结并研究中医药治疗异位妊娠的用药规律。结果：共筛选纳入相关方剂125首，涉及不同中药153味，其中频次 ≥ 30次的有12味，用药以活血化瘀药为主，兼以清热解毒类药、补益气血类药，对所有药物进行四气五味的分析，性味多寒、平、温、凉，部分动物类药味咸，主入心、肝、脾三经；其中使用频率最高的前十味药为：丹参、桃仁、赤芍、莪术、三棱、天花粉、蜈蚣、红花、紫草、当归。结论：中医药治疗异位妊娠主要以活血化瘀、清热解毒类物为主，中药治疗异位妊娠优选丹参、桃仁、赤芍、莪术、三棱、天花粉、蜈蚣、红花、紫草、当归，为临床诊疗提供一定理论依据。

Abstract: Objective: To explore the current clinical application status and patterns of traditional Chinese medicine in the treatment of ectopic pregnancy through data mining and analysis. Method: The system collected clinical research literature on the treatment of ectopic pregnancy with traditional Chinese medicine from databases such as China National Knowledge Infrastructure (CNKI), Wanfang Data, and CQVIP from January 2010 to December 2023. Excel was used for standardized statistics, and the standardized prescription materials were input into the “Traditional Chinese Medicine Inheritance Assistance Platform (V2.5)” for statistical analysis. The frequency of medication, sexual and taste meridian differentiation, prescription rules, and new prescriptions were analyzed, and the medication rules of traditional Chinese medicine in the treatment of ectopic pregnancy were summarized and studied. As a result, a total of 125 relevant prescriptions were screened and included, involving 153 different traditional Chinese medicines. Among them, 12 herbs were used with a frequency of ≥ 30 times. The main drugs used were blood activating and stasis removing herbs, as well as heat clearing and detoxifying herbs and tonifying Qi and blood herbs. The analysis of the four qi and five flavors of all herbs showed that their properties were mostly cold, calm, warm, and cool, and some animal medicines had salty flavors, mainly entering the heart, liver, and spleen meridians; The top ten medicines with the highest frequency of use are: Danshen, Taoren, Chishao, Curcuma, Sanjing, Tianfen, Centipede, Honghua, Zicao, and Danggui. Conclusion: Traditional Chinese medicine mainly focuses on promoting blood circulation, removing blood stasis, clearing heat and detoxifying substances for the treatment of ectopic pregnancy. Danshen, Taoren, Chishao, Curcuma, Sanjing, Tianfen, Centipede, Honghua, Zicao, and Danggui are preferred for the treatment of ectopic pregnancy, providing a certain theoretical basis for clinical diagnosis and treatment.