黑木耳多糖降血脂的Meta分析

Meta-Analysis of Auricularia auricula-judae Polysaccharide in Reducing Blood Lipids

摘要: 为评价黑木耳多糖与高血脂发病风险的相关性，本文通过系统检索中国知网、万方数据、维普网(中国科技期刊数据库)、Embase、PubMed、Cochrane Library数据库，应用RevMan 5.4软件对黑木耳多糖降血脂的TC、TG、HDL-C、LDL-C、LCAT指标进行Meta分析。本文共纳入10篇随机对照试验，Meta分析结果显示：血清总胆固醇(TC)指标[MD = −1.3, 95% CI (−1.68, −1.93), P < 0.00001]，血清甘油三酯(TG)指标[MD = −0.7, 95% CI (−0.77, −0.40), P=0.006]，血清低密度脂蛋白指标[MD = −0.58, 95% CI (−0.77, −0.40), P < 0.00001]，血清高密度脂蛋白(HDL-C)指标[MD = 1.06, 95% CI (0.72, 1.41), P < 0.00001]，实验组与对照组比较有明显改善，差异性具有统计学意义。偏倚性分析表明，TC、TG、LDL-C、HDL-C水平漏斗图均有个别文献脱离漏斗图，具有一定的偏倚性。总体结果表明：黑木耳多糖在改善高血脂水平方面具有一定程度的效果，与高血脂症发病风险具有负相关性。

Abstract: To evaluate the correlation between Auricularia auricula-judae polysaccharide and the risk of hyperlipidemia, this study uses Meta-analysis method to analyze the TC, TG, HDL-C, LDL-C and LCAT indexes of Auricularia auricula-judae polysaccharide in reducing blood lipid by searching CNKI, Wanfang data, VIP (China Science and Technology Journal Database), Embase, PubMed, Cochrane Library databases, and using RevMan 5.4 software. In this paper, 10 randomized controlled trials were included. Meta-analysis results showed that: serum total cholesterol (TC) index [MD = −1.3, 95% CI (−1.68, −1.93), P < 0.0001], serum triglyceride (TG) index [MD = −0.7, 95% CI (−0.77, −0.40), P = 0.006], serum low-density lipoprotein index [MD = −0.58, 95% CI (−0.77, −0.40), P < 0.0001], serum high-density lipoprotein (HDL-C) index [MD = 1.06, 95% CI (0.72, 1.41), P < 0.0001], the experimental group and the control group have significantly improved, the difference is statistically significant. Bias analysis showed that there was individual literature that deviated from the funnel plots of TC, TG, LDL-C, and HDL-C levels, indicating a certain degree of bias. The overall results showed that Auricularia auricula-judae polysaccharide had a certain effect on improving the level of hyperlipidemia and had a negative correlation with the risk of hyperlipidemia.