基于蛋白质组学的动脉粥样硬化研究进展

Advances in the Study of Atherosclerosis Based on Proteomics

摘要: 动脉粥样硬化(atherosclerosis, AS)是心血管疾病最常见的危险因素之一，随着现代社会生产生活方式、饮食结构等因素的改变，其发病率显著增加，而AS的斑块也常引起冠心病、脑血管意外的风险增加。近年来关于AS分子机制的研究不少，但都偏向于局部某种信号通路或某种细胞的功能，都没有从整体水平上来研究其机制。蛋白质组学是从整体水平基础上，研究蛋白质结构、功能、相互作用，获得蛋白质水平上关于疾病发生发展、细胞代谢等整体而全面的认识。基于蛋白质组学角度研究AS的血液蛋白、组织蛋白、细胞外囊泡蛋白、斑块内蛋白等，能从整体水平认识AS的分子机制。现阐述基于蛋白质组学的AS研究进展。

Abstract: Atherosclerosis (AS) is one of the most common risk factors for cardiovascular disease. With changes in production and life style, diet structure and other factors in modern society, the incidence has increased significantly. AS plaques also often cause increased risk of coronary heart disease and cerebrovascular accidents. In recent years, there have been a lot of studies on the molecular mecha-nism of AS, but all of them tend to focus on some local signaling pathway or some cell function, but have not studied its mechanism from the overall level. Proteomics studies protein structure, function and interaction on the basis of the overall level, so as to obtain an overall and comprehensive understanding of disease development and cell metabolism at the protein level. The study of blood proteins, histones, extracellular vesicle proteins and plaque proteins of AS from the perspective of proteomics can understand the molecular mechanism of AS from the overall level. The progress of AS research based on proteomics is reviewed here.