T淋巴细胞亚群在移植物抗宿主病中的研究进展
Research Progress of T Lymphocyte Subsets in Graft-Versus-Host Disease
DOI: 10.12677/acm.2024.14102625, PDF,    科研立项经费支持
作者: 黄 欣, 王 敏, 唐彩练：右江民族医学院研究生学院，广西 百色；王小超*：右江民族医学院附属医院血液科，广西 百色
关键词: 移植物抗宿主病；异基因造血干细胞移植；T淋巴细胞亚群；NK细胞；Graft-Versus-Host Disease； Allogeneic Hematopoietic Stem Cell Transplantation； T Lymphocyte Subsets； NK Cells
摘要: 移植物抗宿主病(GVHD)是异基因造血干细胞移植后的主要并发症，主要源于移植物中的免疫活性细胞(特别是T淋巴细胞)对宿主组织发动免疫攻击所引起，是导致移植后复发及死亡的主要原因之一。因此，早期预测及识别GVHD，可以更好地提供干预措施，有助于提高患者的生存率并改善预后。本文主要探讨T淋巴细胞亚群中的CD4+ T细胞、CD8+ T细胞以及NK细胞在GVHD免疫方面中的意义及相关性。
Abstract: Graft-versus-host disease (GVHD) is a major complication after allogeneic hematopoietic stem cell transplantation, which is mainly caused by the immune attack of the grafted cells (especially T lymphocytes) on the host tissue, and is one of the main causes of recurrence and death after transplantation. Therefore, early prediction and identification of GVHD can provide better interventions to improve patient survival and prognosis. This paper mainly discusses the significance and correlation of CD4+ T cells, CD8+ T cells and NK cells in T lymphocyte subsets in GVHD immunity.
文章引用：黄欣, 王小超, 王敏, 唐彩练. T淋巴细胞亚群在移植物抗宿主病中的研究进展[J]. 临床医学进展, 2024, 14(10): 98-104. https://doi.org/10.12677/acm.2024.14102625

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