隐匿性甲状腺滤泡癌伴肺转移：1例报告及文献复习

Occult Follicular Thyroid Carcinoma with Lung Metastasis: A Case Report and Literature Review

摘要: 目的：本文的目的是回顾最近关于隐匿性甲状腺状癌伴肺转移相关的文献。方法：我们报告了一个病例，并回顾了有关隐匿性甲状腺状癌伴肺转移的现有文献。结果：甲状腺癌首先表现为转移或继发性副肿瘤现象，我们将这部分癌症称为“隐匿性甲状腺癌”。隐匿性甲状腺癌远处转移常见为肺、骨转移，少见的脑、脊髓等部位的转移。为避免临床上隐匿性甲状腺癌的漏诊，在诊断方面有文献建议病理联合分子标志物进行诊断；在治疗方面有文献建议应将中央淋巴结清扫术和全甲状腺切除术一起进行。结论：对于隐匿性甲状腺癌来说，早期诊断及早期干预显得尤为重要。我们建议在临床上出现其他部位恶性肿瘤时，要考虑到隐匿性甲状腺癌远处转移的鉴别诊断。

Abstract: Purpose: The purpose of this article was to review the recent literature related to occult thyroid-like carcinoma with lung metastases. Methods: We report a case and review the current literature on occult thyroid carcinoma with lung metastases. Results: Thyroid cancers first present as metastatic or secondary paraneoplastic phenomena, and we refer to this subset of cancers as “occult thyroid cancers”. Distant metastases of occult thyroid cancer are commonly lung and bone metastases, and rarely brain and spinal cord metastases. In order to avoid underdiagnosis of occult thyroid cancer, some literature suggests that pathology and molecular markers should be combined for diagnosis, and some literature suggests that central lymph node dissection and total thyroidectomy should be performed together for treatment. Conclusion: Early diagnosis and early intervention are particularly important in occult thyroid cancer. We suggest that the differential diagnosis of distant metastasis of occult thyroid cancer should be taken into account in the clinical presentation of malignant tumors in other sites.