SGLT-2抑制剂对缺血性脑卒中的影响及其作用机制研究进展
Progress in the Study of the Effect of SGLT-2 Inhibitors on Ischemic Stroke and Its Mechanism of Action
DOI: 10.12677/acm.2024.14102766, PDF,    国家自然科学基金支持
作者: 李 蕾, 覃诗源, 高 爽, 杨雅芝, 陈 钰, 王 颖*:昆明医科大学第二附属医院神经内科,云南 昆明
关键词: 缺血性脑卒中钠–葡萄糖协同转运蛋白2抑制剂糖尿病Ischemic Stroke Sodium-Dependent Glucose Transporters 2 Inhibitor Diabetes Mellitus
摘要: 糖尿病是缺血性脑卒中的重要危险因素之一,钠葡萄糖协同转运蛋白抑制剂作为一种新型的降糖药可通过抑制肾脏血管对葡萄糖吸收而起到控制血糖作用,同时有抑制动脉粥样硬化、降脂及减轻体重等功能。本文通过从钠–葡萄糖协同转运蛋白2抑制剂作用机制出发,结合既往基础及临床研究报告。对钠–葡萄糖协同转运蛋白2抑制剂对缺血性脑血管病的影响及作用机制作一简要综述。
Abstract: Diabetes mellitus is one of the most important risk factors for ischemic stroke. Sodium-glucose cotransporter protein inhibitors, as a new type of hypoglycemic drugs, can control blood glucose by inhibiting glucose uptake by renal blood vessels, and at the same time inhibit atherosclerosis, lower lipids and reduce body weight. In this paper, the mechanism of sodium-glucose cotransporter protein 2 inhibitor is analyzed from the perspective of its mechanism of action, combined with the reports of previous basic and clinical studies. The effects of sodium-glucose cotransporter 2 inhibitors on ischemic cerebrovascular disease and its mechanism of action are briefly summarized.
文章引用:李蕾, 覃诗源, 高爽, 杨雅芝, 陈钰, 王颖. SGLT-2抑制剂对缺血性脑卒中的影响及其作用机制研究进展[J]. 临床医学进展, 2024, 14(10): 1054-1060. https://doi.org/10.12677/acm.2024.14102766

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