靶向APOE的神经退行性疾病研究进展
Research Progress of Neurodegenerative Diseases Targeting APOE
摘要: 载脂蛋白E (Apolipoprotein, APOE)基因是阿尔茨海默病(Alzheimer’s Disease, AD)公认的主要遗传风险因子。与APOEε3等位基因相比,APOEε4等位基因增加AD风险,ε2等位基因降低风险,在AD发病机制研究和治疗中受到重要关注。越来越多的证据表明APOE影响β-淀粉样蛋白(β-amyloid, Aβ)和tau病理,参与神经系统疾病中的脂质代谢和神经炎症等脑内途径过程。因此,阐明APOE与AD之间联系,以AOPE为靶标,对于相关神经退行性疾病的治疗进展具有积极的意义。现以APOE在AD治疗中的最新研究进展及讨论未来靶向APOE的其他神经系统疾病治疗机会与策略进行综述。
Abstract: Apolipoprotein E (APOE) gene is a major genetic risk factor of Alzheimer’s Disease (AD). Compared with APOEε3 allele, APOEε4 allele increases the risk of AD, while APOEε2 allele decreases the risk, which has attracted great attention in the pathogenesis and treatment of AD. More and more evidences show that APOE affects the pathology of β-amyloid (Aβ) and tau, and participates in the brain pathways such as lipid metabolism and neuroinflammation in nervous system diseases. Therefore, it is of positive significance to clarify the relationship between APOE and AD and take AOPE as the target for the treatment of related neurodegenerative diseases. In this paper, the latest research progress of APOE in the treatment of AD and discusses the treatment opportunities and strategies of other nervous system diseases targeting APOE in the future.
文章引用:苏航, 赵鹏, 孙志勇. 靶向APOE的神经退行性疾病研究进展[J]. 老龄化研究, 2024, 11(5): 2028-2038. https://doi.org/10.12677/ar.2024.115295

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