《妇科名家诊治PCOS临证经验》用药规律多层次数据挖掘研究

Multi-Level Data Mining Study on Medication Rule of Clinical Experience of Gynecologists in Diagnosis and Treatment of Polycystic Ovary Syndrome

摘要: 目的：对《妇科名家诊治PCOS临证经验》一书中的方药进行数据挖掘，分析其用药配伍规律，为多囊卵巢综合征的临床治疗提供新思路。方法：收集书中名家有效医案处方，建立处方数据库，使用Excel软件提取方药信息，采用R、SPSS Statistics等软件对多囊药物进行用药频次统计、性味归经统计及关联规则分析、聚类分析、复杂网络分析等。结果：1) 共纳入264张治疗多囊卵巢综合征有效处方，涉及中药258味，其中使用频次 > 40次的中药共28味，出现频次最高的单味药为当归(177次)，高频药物有当归、菟丝子、香附、茯苓、川芎、熟地黄等；2) 药物四气以温、平、微寒为主，五味以甘、辛、苦为主，归经以肝、脾、肾为主；3) 关联规则显示，当归配伍熟地为最常用药对；聚类分析得出3个基础处方。结论：全国妇科名家治疗多囊卵巢综合征以补益肝肾、活血祛瘀、健脾化痰为总则，多用补益药、活血药和祛湿化痰药。

Abstract: Objective: To mine prescription data from the book Clinical Experience of Gynecologists in Diagnosis and Treatment of Polycystic Ovary Syndrome and analyze its drug compatibility, so as to provide new ideas for clinical treatment of polycystic ovary syndrome. Methods: Effective prescriptions in books were collected, prescription database was established, prescription information was extracted by Excel software, and statistics of drug frequency, sex and taste normalization, association rule analysis, cluster analysis and complex network analysis of multi-capsule drugs were performed by R and SPSS Statistics software. Results: 1) A total of 264 effective prescriptions were included in the treatment of polycystic ovary syndrome, involving 258 flavors of TCM, among which 28 flavors of TCM were used more than 40 times, the most frequent single drug was Angelica sinensis (177 times), and the high-frequency drugs were Angelica sinensis, Cuscuta seed, Xiangfu, poria, ligusticum Chuanensis, Rehmannia radix; 2) The four qi of medicine are mainly warm, flat and slightly cold, the five taste are mainly sweet, xin and bitter, and the normalization of meridian is mainly liver, spleen and kidney; 3) Association rules showed that Angelica sinensis with Rehmannia radix was the most commonly used pair of medicines. Three basic prescriptions were obtained by cluster analysis. Conclusion: National gynecologists treat polycystic ovary syndrome by the general principles of tonifying liver and kidney, promoting blood circulation and removing blood stasis, invigorating spleen and eliminating phlegm, and most of them use tonic herbs, blood-activating herbs, and dampness-eliminating and phlegm-resolving herbs.