艾司氯胺酮的临床应用进展
Progress in the Clinical Application of Esketamine
摘要: 艾司氯胺酮是外消旋氯胺酮的S-对映异构体,是一种新型的具有镇痛作用的静脉麻醉药,与氯胺酮相比,具有起效快、代谢快、镇痛作用强、对呼吸影响小、术中血流动力学稳定、副作用少、缩短患者术后苏醒时间等优点,更适合临床使用。在麻醉诱导、维持、术后镇痛及精神疾病等领域有着广泛的应用。因此,本文将对艾司氯胺酮的临床应用、抗抑郁作用以及对术后认知功能障碍(POCD)的影响的研究进展进行综述,为艾司氯胺酮的临床合理使用提供参考依据。
Abstract: Esketamine is the S-enantiomer of racemic ketamine, which is a new type of intravenous anesthetic with analgesic effect. Compared with ketamine, esketamine has the advantages of fast onset, fast metabolism, strong analgesic effect, small impact on respiration, intraoperative hemodynamic stability, less mental side effects, and shortening the postoperative recovery time of patients, and is more suitable for clinical use. It has a wide range of applications in the fields of anesthesia induction, maintenance, postoperative analgesia, and psychiatric diseases. Therefore, this article will review the clinical application, antidepressant effect and impact of esketamine on Postoperative Cognitive Dysfunction (POCD), so as to provide a reference for the rational clinical use of esketamine.
文章引用:乔宇, 韩志强. 艾司氯胺酮的临床应用进展[J]. 临床医学进展, 2024, 14(10): 1592-1599. https://doi.org/10.12677/acm.2024.14102835

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